the Sai Lab

Our work presents the first cryo-ET image of the authentic #Mpox virus and its 3D reconstruction. It's a huge virus. Details in: rdcu.be/dXFp2

Our new work is online in PNAS today. In this work, electron-beam & PFA inactivated Delta virions were imaged by cryo-ET and compared; homotypic fusion were found between the virions. In situ architecture and membrane fusion of SARS-CoV-2 Delta variant pnas.org/doi/10.1073/pn…

@AMannanBaig @ChlandaL Here is the manuscript, critics welcome.
biorxiv.org/content/10.110…

@ChlandaL @drlisai Couldn't get it with DOI

@SystemsVirology Here is the manuscript, critics welcome.
biorxiv.org/content/10.110…

@drlisai Thanks for citing our works. Your work is amazing! Who imagined Delta changes the morphology of viral particles...😵 Any thoughts on how the morphology of Delta virion is changed? And does it associate with Delta's higher fusogenicity?

omg

@SystemsVirology We think it is spike related, because the other structural proteins have not mutated much. we proposed a self-fusion theory for the invagination formation (fig 5b), but are open for suggestions

@CVRHutchinson @CeriFielding @ChlandaL Glad you like it.

@ChlandaL Thanks, it's surprising to see a few mutations can change the virus dramatically

@Javier__CB Dear Javier, this is our work, thanks for increasing the publicity of it, so that everyone knows what the virus look like.

#COVID19 El SARS-CoV-2 ha sido aislado y purificado. Aquí podemos ver en un video partículas virales purificadas. Sobre ellas, se señalan las distintas proteínas y estructuras que las conforman. Fuente: sciencedirect.com/science/articl…

Glad to have contributed a figure to this exciting paper on ERGIC. rdcu.be/cyEEr

@SchurLab haha, lol on “hype”. Many structural biologists are rushing into ET, but few know how long the learning curve is.

Looking forward to speak at the International conference "#COVID19, Advances and Remaining Challenges", 29 Sep.-1 Oct. 2021, organised by @institutpasteur @PasteurVirology covid19.conferences-pasteur.org

@dferhadian thanks!

Cryo-electron tomography of enveloped viruses: Trends in Biochemical Sciences cell.com/trends/biochem…

@utokawa Thanks for sharing my work. Are you working in STRUBI or Dunn school?

Cryo-electron tomography of enveloped viruses #relatedArticles" target="_blank" rel="nofollow noopener">cell.com/trends/biochem…

@GroupZhang @DiamondLightSou @OxfordStrubi Jiwei made it!

I draw Fig.1 to pay tribute to T.Baker and S.Fuller, two pioneer&masters in cryoEM structural virology. S.Fuller was a founder of OPIC @OxfordStrubi, which cultivated #cryoET virology, @BriggsGroup, Guilia and many younger #cryoET generations, including me authors.elsevier.com/a/1djZu3S6GfF7…

My review is online today on @TrendsBiochem, highlighting the recent advances in in-situ structural virology and cryo-ET method developments. The efforts shed light on the assembly and intracellular activities for some most threatening viruses. authors.elsevier.com/a/1djZu3S6GfF7…

@bengeliscious Hi Ben, 3 hours from the city. Only a fraction of great wall was restored, most, like this piece, were aged. The aged Walls are mostly built on very steep mountains, climbing it is like climbing a cliff

@drlisai Beautiful🌸! Is this span of wall an hour or two from Beijing? It triggers my ancient memories of visiting the wall when I was 17 years old. It feels to me like it is the same spot. But that was, wow... 23 years ago👴. I wonder if I can dig up some old photos?🖼️

Ancient great wall surrounded by peach flowers, found my peace in the mountains after a week of meetings.

@DrSusanNasif Thanks for liking our work, Susan.