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Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
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siddhartha jena
520 posts
siddhartha jena
@epijenatics
@hscrb/@broadinstitute postdoc with @jd_buenrostro looking at chromatin and signaling. previously: PhD @princetonmolbio with @toettch
somewhere in the nucleus Katılım Kasım 2011
799 Takip Edilen421 Takipçiler
siddhartha jena retweetledi
🚨New paper alert!🚨 Cells integrate signals into decision-making. But how do levels of signaling influence cell-fate transitions? Is more always better? Or is there an “optimal” level for cell-fate programming? If we could tune signaling, could optimize production of neurons? Read on! (1/n)🧵
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@Oli_TN @JD_Buenrostro thank you! I think there's a lot of potential in combining the two in future work as well :)
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@epijenatics @JD_Buenrostro This is really cool, congrats mate! The “screen on mechanism” strategy is a fresh angle amongst all the functional screening papers out there
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Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
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Hire him ASAP!! One of the smartest, fun and caring scientists out there. And this science is incredible! Engineering histones are finally here!
siddhartha jena@epijenatics
Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
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@JD_Buenrostro One last thing - I am on the job market! My lab will extend this work to decode resilient chromatin: adaptations that allow for survival in harsh environments. These hold the 🔑 to designing cells that thrive under stress, esp. as we push the limits of where we go ❄️🚀🪐🌱9/9
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Huge thanks to all co-authors and the inimitable
@JD_Buenrostro for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: biorxiv.org/content/10.110…
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siddhartha jena retweetledi
My NIH Study Section (MABS) was cancelled a little more than 24 hours before the start. With 35 members, & 45 h of reviews/member, that wasted 1575 hours of scientists' unpaid time. @NIH, protect scientists right now & cancel all study sections until you get clarity. @NIHDirector
GIF
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Doing big things @maxzwilson!
Princeton MolBio@PrincetonMolBio
MolBio grad and postdoc alum, Max Wilson *15, currently Asst Prof at UCSB's Dept of Molecular, Cellular & Developmental Biology is Co-founder of Integrated Biosciences and for his first sabbatical will work as Chief Scientific Officer of the 2022 startup. integratedbiosciences.com/news
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Great work and some really beautiful imaging data @h4rrymcnamara , @toettch and team!
Harry McNamara@h4rrymcnamara
Our study decoding gastruloid symmetry breaking is now live @NatureCellBio! rdcu.be/dVMLG Thank you to the NCB edititorial team and to our reviewers for a constructive review process which helped improve our study. A thread on updates (1/n):
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Really superb work from my awesome labmates! It's been awesome watching this project develop over the years.
zack chiang@z_chiang
7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/
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siddhartha jena retweetledi
Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n)
Link: doi.org/10.1101/2024.0…
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T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this gap (biorxiv.org/content/10.110…):
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