Eylon Bachar
197 posts
Eylon Bachar
@eylon1234
People, freedom and hard problems. Happy dad.
Israel Katılım Mart 2012
449 Takip Edilen68 Takipçiler
every humanoid demo i've seen is, in my opinon, bottlenecked by the same thing: we have great actuators and no ground truth for intent. as a start, upstream EMG is probably the cheapest true intent sensor that already exists beyond CV. i'm surprised people haven't wired it to more stuff
i'd do it
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Eylon Bachar retweetledi
Yes! Make Sci-fi Optimistic Again
Robotbeat🗽 ➐@Robotbeat
Scifi being taken over by "cautionary tales" is problematic... If there's no positive vision of the future, people will just emulate negative ones even if the author "intends" it opposite. Sorry that it's not cool & intellectual to write a positive story, but it's essential.
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🧬 Thoughts from the scientists who shaped aging research:
“We should not expect there to be a single mechanism of aging.”
— Tom Kirkwood
This is one of the most important lessons from evolutionary theories of aging.
Aging is not simply telomeres, DNA damage, mitochondria, senescence, inflammation, or proteostasis collapse alone. These mechanisms interact, reinforce each other, and vary across tissues, species, and individuals.
Kirkwood’s disposable soma theory helped frame aging as a problem of imperfect maintenance: evolution did not necessarily optimize the body for indefinite repair.
That is why aging biology is so complex and so fascinating. 🔬
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@aquinasheard23 Likewise. I think they’re starting to. “Unschooling” is getting popular in the US, and hopefully it will propagate fast.
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Just maybe….as many parents are fretting about social media for kids/teens (sometimes understandably)…..they will eventually turn this scrutiny to what’s “under the hood” in their local public school….a guy can dream
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Cure diseases. Automate labor. Expand intelligence. Multiply energy. Explore the universe.
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Compulsory schooling is an anti-human institution. It suppresses creativity, diversity, critical thinking, and personal agency, the very qualities that make us human.
Chris Fore@chriscfore
Name an education opinion that’ll have you like this…
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would you be happy to offload structured conscious reasoning to AI, and become an intuitive-only species?
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@SterlingCooley Per OrchOR theory we need a quantum computer to model mt dynamics. Regardless, I think a nested neural network architecture will be beneficial nonetheless.
@StuartHameroff
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Okay business idea here guys:
Why don't we try building silicon chips just like the 6 cortical layers of the brain ?
And model Microtubule dynamics the most in layer 5, just the way nature did it to give us consciousness ?
Sterling Cooley@SterlingCooley
Pyramidal Neurons, which are super-rich in Microtubule pairings (dense) are likely the true "embedding" location of a 6 layer cortical stack. Eventually mainstream neuroscience will catch up We are so early guys :D haha
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hey, i'm hiteyjit.
i'm a neuroscientist, founder, filmmaker, builder of cool hardware, and ever so occasional philosopher. been building machines since i was 8 – first for myself, then a nonprofit i founded at 12 that scaled across three countries teaching kids to make their own.
somewhere in there i noticed the machine i cared most about was the one actually doing all the building; so, i pivoted into neuroscience @ uoft and then spent a year at harvard stimulating the hell out of some neurones. the one ground truth i've found though all this i've found is that people only believe what they can physically feel; every other medium is borrowing trust from that one.
if it were up to me, id change the laws of physics so its easier for me to decode inner thoughts. since i can't, i'm doing the next best thing by building beautiful instruments for the mind with some phenomenal people.
sf is now home #7. reach out if you're here + you make physical things (films count) + you're up for having your worldview argued with!
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Yes. If you're building for schools, it ends up as coerced "learning", then it loses the whole point. Good edtech outcomes require voluntary education.
Kaelin Hooper 👾@KaelinHooper
Exactly how I feel about education. If you just build a learning tool, you end up selling to schools. - Tesla didn't just build a new battery - SpaceX didn't just make better cheaper heat shields Recess isn't just making software. We're building the whole schooling vertical from the ground up, because it's required to create the next generation of education outcomes.
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Eylon Bachar retweetledi
Poverty is caused by nothing—it is the state of Nature into which humanity was born.
Meanwhile, wealth is not some mana from the sky delivered by fiat or by Nature but rather must be created by man.
Like knowledge in contrast with ignorance, it is wealth, not poverty, that demands explanation.
~Conjecture Institute President @ChipkinLogan
Institute of Economic Affairs@iealondon
💰 "Wealth taxes, that's the thing about them. They have been tried many, many times before. This is not a remotely new idea." @K_Niemietz on @PiersUncensored tells @garyseconomics that half of Western Europe had wealth taxes until the early 1990s, and abolished them for good reason.
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Eylon Bachar retweetledi
@visegrad24 The enemies of civilisation typically attack too early.
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Eylon Bachar retweetledi
Reducing sleep will be the first major lifespan extender.
rico meinl@ricomnl
glad someone is tackling this! making a drug for shorter sleep (mod. downsides) could increase (awake) lifespan by 15-20%
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Eylon Bachar retweetledi
How did we achieve so fast end-to-end testing? Our proprietary Capable Core: We verticalized key steps of preclinical development. Our platform consists of 6 semi-autonomous modules, most of which we re-engineered to run 10–20x faster.
Drug design, ML infra, rapid synthesis, quality control, cell testing, and then mouse testing.
Our first modality at the 24h pace is binders & peptides--including complex modifications, cyclization, and noncanonical amino acids.
Mouse studies: For many of the biologically fast readouts, such as our short sleeper programs, we are able dose new drugs in placebo-controlled in vivo studies within that 24h period too and can read out early significant differences between drug candidates rapidly.
We achieved this through an in vivo facility in the lab, pre-approved protocols, and veterinarians & in vivo researchers on standby. This doesn't work for all indications: For Alzheimer's models the time-to-first-signal in vivo read-out is longer. For all drug candidates, before clinical testing we do standard chronic studies.
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Eylon Bachar retweetledi
Bioelectric signals and extracellular vesicles carry the information that guides biological functions through their spatial organization, temporal dynamics, and context.
P. E. Sottas@pesottas
Elon Musk: "You’ve never seen someone with an old left arm and a young right arm, such synchronized aging hints at a common biological mechanism. Once that mechanism is understood, the solution may appear surprisingly obvious." Simple: your left arm communicates with your right arm, they are not aging in isolation. By the time you finish reading this paragraph, your cells will have released roughly 1 trillion extracellular vesicles into your body, these tiny communication messengers that carry, among other things, aging signals. We changed that communication system to a more youthful state and reversed biological aging by more than 8 days for every day participants spent in our human trial. Fix the signals, not just the cells.
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