
Sam
1.7K posts





As a software engineer, you should be able to solve a LeetCode problem.

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!


First 3 minutes of the 1998 Game 6 NBA Finals Basketball used to be so pure 🔥



New blog post: The third wave of American philanthropy Hundreds of billions of dollars in new philanthropic capital will soon become liquid. The OpenAI Foundation holds 26% of OpenAI, worth about $220B at today’s valuation. Anthropic’s seven co-founders have pledged to give away 80% of their wealth and have instituted the most aggressive donor matching program for employees in tech history. How much does this all add up to? And how meaningful is that in the context of philanthropy today? I was doing some simple napkin math to wrap my head around the scale of what’s coming, and radicalized myself in the process. I had dramatically underappreciated the scale of the philanthropic capital that’s about to become available and the corresponding gap in talent and organizations that will be needed to make the most of it. This piece aims to directionally sketch the scale of what’s coming, the gap in operational capacity needed to absorb it, and what we can do to fill it. (Link to full post in reply)

Gloating about people’s jobs getting wiped out and championing sticking people on government checks for subsistence… yeah, not hard to see why many would not look favorably on that.

2 people can’t physically hold back the Agibot A3 when it malfunctioned. Looks like a policy degradation under instability.

America has the World Cup and its 250th birthday this summer, but the public doesn't seem to really care about either event. It's a bit weird.



One of the stranger things about modern life is how easily you can simulate fulfillment. It's the first time in history where the gap between dopamine hits can be reduced to zero, allowing you to indefinitely postpone fulfillment. The balloon never has to touch the ground and your brain doesn’t care that none of the hits compound.

OMG, do you know how much of a flex this is?? 😭

Elliott Erwitt #photography Wyoming, USA. 1954.









