Gopal Jayaraj

Most delighted to share our work led by the stellar @mabedimu under the aegis of Ulrich Hartl @MPI_Biochem, initiated by @prasad_kasturi on novel aspects of translational quality control coordinated by GCN1! #ribosome #collisions #codonnonoptimality

Meet NovoTags, a new class of fluorescent imaging probes that combines AI-driven protein design from #HHMIInvestigator David Baker w/ ultra-bright dyes from Janelia’s Luke Lavis, enabling scientists to watch dozens of proteins inside a cell at once: bit.ly/4noBb06.

We have developed a cysteine-free, highly thermostable tagging system, UTag, that enables single-mRNA translation tracking in live cells. You may wonder how different tagging systems affect translation kinetics—we addressed this by performing a systematic comparison.

mtHsp70 chaperone converts mitochondrial proteostasis stress into impaired protein import | PNAS pnas.org/doi/10.1073/pn…

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis dlvr.it/TR3JRW

Samant Lab #preprint no. 4: “Ubi-SCAPE enables deep exploration of the poly-ubiquitylome” biorxiv.org/content/10.648… 🧵 to follow soon—but check it out in the meantime! #proteomics #TeamMassSpec

Nature research paper: Single-molecule dynamics of the TRiC chaperonin system in vivo go.nature.com/4a1ubBi

Single-molecule dynamics of the TRiC chaperonin system in vivo: nature.com/articles/s4158…

Single-molecule dynamics of the TRiC chaperonin system in vivo nature.com/articles/s4158…

‘The Thinking Game’ documentary has just passed 200M views on YouTube in just 4 weeks! 🤯Perfect holiday viewing if you’re interested in a behind-the-scenes look at how an AGI lab works, or what goes into making a Nobel Prize winning project like AlphaFold happen.🧬🚀

Online Now: GCN2 monitors mRNA translation termination dlvr.it/TPkDzn

Nick Lane has a theory about the evolution of life which explains *why* life is the way that it is - all the contingent mechanisms you’re just supposed to take as givens in biology class. He thinks early life was continuous with the spontaneous chemistry of deepsea hydrothermal vents. I find it remarkable that with just that starting point, he can potentially explain so much: - Why are there two sexes? Why sex at all? - Why are bacteria so relatively simple despite being around for 4 billion years? Why is there so much shared structure between all eukaryotic cells despite the enormous morphological variety between animals, plants, fungi, and protists? - Why did the endosymbiosis event that led to eukaryotes happen only once, and in the particular way that it did? - Why is all life powered by proton gradients? Why does all life on Earth share not only the Krebs Cycle, but even the intermediate molecules like Acetyl-CoA? His theory implies that early life is almost chemically inevitable (potentially blooming on hundreds of millions of planets in the Milky Way alone, and based the very same chemical metabolism). The real bottleneck for intelligent life ready to explore the cosmos, in his view, is the eukaryotic cell. 0:00:00 – The singularity that unlocked complex life 0:09:10 – Early life continuous with Earth's geochemistry 0:24:20 – Eukaryotes are the great filter for intelligent life 0:43:00 – Mitochondria are the reason we have sex 1:08:56 – Are bioelectric fields linked to consciousness?

Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset medrxiv.org/content/10.110…

You can not do Bioinformatics with hard cutoffs and thresholds Let me tell you something real: Biology is more about p-values. It’s messier than that. 🧵

My former PhD advisor got the Nobel Prize (John Clarke at Berkeley). It was without question the dullest work I’ve ever done in life and should have left earlier.

Our new @Nature study reveals a proteotoxic shock as a key mechanism of T-cell exhaustion. TexPSR (proteotoxic stress response in T-cell exhaustion) is driven by increased protein synthesis + buildup of misfolded proteins, leading to T-cell dysfunction. 👉 rdcu.be/eI3ch

Early-career scientists: here’s your chance to lead independent research!🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! mpg.de/career/max-pla…👉

Online Now: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation dlvr.it/TN0hJT

We're recruiting a Research Assistant (new grant--details to follow!)--come help us work with primary human patient material to make cool 2D/3D co-culture systems, & learn more about how #proteostasis & #senescence play together in these contexts: babrahaminstitute.livevacancies.co.uk/#/job/details/…

And here goes our brand new flyer #postdocjobs. Please RT!

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates: Cell cell.com/cell/fulltext/…