Haochen Zhang

1/n Most productive 💡collaborative meeting with #likeminded colleagues friends - full 🟣 circle of older and new mentors #AACR26 @AACR @haochenz39 Benoit Rousseau @MarcHilmi David Tuveson Binbin Binbin Zheng Ying Long @MichaelMayMD @jakelee0711

@CentralParkWMD is the most tireless person I have met at MSK. What a great milestone. Also a great blessing for pancreatic cancer patients

Very excited to share this paper that our @valarlabs team published: We extended our prior work with the Computational Histologic Artificial Intelligence (CHAI) platform, which analyzes solely histomorphic features ("histomics"), to develop and validate a biomarker that predicts optimal first-line chemotherapy for patients with advanced pancreatic cancer, often considered to be the most technically and clinically challenging cancer. Histomics is an often overlooked yet powerful modality that can be leveraged for precision medicine. More exciting work to come!

Thrilled to share my PhD paper, now published in @NatureGenet! We used single-nucleus DNA sequencing to unravel the complex genomic evolution of pancreatic cancer, as illustrated by the cover art by my amazing mentor @ciacobu. #Genomics #PancreaticCancer nature.com/articles/s4158… Pancreatic cancer is notoriously difficult to treat. Several precision medicine opportunities are on the horizon. but we still do not fully understand the cancer's molecular vulnerabilities. Bulk sequencing gives a crude picture, but we need to see the cancer at single-cell level to further understand and treat it. #PrecisionOncology #CancerEvolution In our study, we analyzed over 137,000 single nuclei from 24 patients with pancreatic cancers in various clinical contexts, and mapped out their evolutionary trajectories at high-resolution. Key finding 1: In tumors with KRAS mutations (the most common driver in pancreatic cancer ), we saw a varied dependence on this gene late in tumor progression. This could explain why KRAS inhibitors work for some patients but not others. #KRAS #TargetedTherapy Key finding 2: For patients with inherited BRCA2 mutations, we discovered diverse ways the cancer gets rid of the remaining healthy copy of the gene. This shapes the tumor’s evolution and can impact therapy response. #BRCA #HereditaryCancer Key finding 3: We found that the inactivation of the TGF-β pathway, which normally suppresses tumor growth, occurs late in tumor development and is constantly selected for as the tumor interacts with associated microenvironment during invasion and metastasis. #Metastasis Our work was enabled by several technical advances including single-nucleus DNA sequencing and accompanying computational analysis tools. They warrant wide clinical application, as they reveal vulnerabilities of cancer at unprecedented resolution and improve precision medicine. #PrecisionMedicine Shoutout to my coauthors that made this possible! @psashittal @benjraphael @CentralParkWMD @MarcHilmi @EileenMOReilly @benjraphael

@CentralParkWMD Thanks man! More coming soon ✊

@haochenz39 congratulations 🎊🎉🍾

Congratulations! Haochen and Kudos to our our team! Here is my steal from the evolutionary geneticist Chris @ciacobu @CpcrMsk and my favorite slide on the complex genome of #PDAC More coming soon stay tuned! @MarcHilmi @EileenMOReilly #KRAS dosage alleles imbalance and #BRCA timing for evolutionary trajectory @MSK_DeptOfMed @MSKCancerCenter

@EricTopol @NatureGenet Thanks for the recognition!

Impressive precision tracing of evolution of pancreatic cancer at single-cell resolution with implications for better treatments @NatureGenet nature.com/articles/s4158…

The investigation found “no evidence of malpractice by other authors,” - wow. Thought the TRACERx was more legit than this

Excited to get this story out by my incredibly talented graduate student @haochenz39 for his thesis work. Keep an eye out for him, rising star for sure! Genomic evolution of pancreatic cancer at single-cell resolution biorxiv.org/content/10.110…

It is a great honor to graduate from @ciacobu’s lab at @GSKGradSchool this summer and preprint my PhD work. Honored to take on the challenge of pancreatic cancer research. Everyone stayed tuned for Chris’ lab because we have many great works brewing ♨️ biorxiv.org/content/10.110…

@CentralParkWMD @ciacobu @CpcrMsk Thanks Wungki!!!

@haochenz39 Haochen is an absolutely talented computational biologist @ciacobu lab @CpcrMsk This single nucleus DNAseq in multiple longitudinal and multi-regional samples for 24 patients with #PancreaticCancer is powerful illustration of cancer evolution. Congratulations 🎊

It’s a big moment in bladder cancer. We’ve been able to successfully validate computational histology based AI biomarkers to predict outcomes and response to first line treatment. Press Release: bit.ly/44q09CF

Maybe the most lovely reflection on a life well lived, amidst a cancer diagnosis, that I’ve ever read. By Simon Boas. jerseyeveningpost.com/news/2024/02/1…

Congratulations, Chris 🎊 EIC CID! @ciacobu @CpcrMsk the new Editor-in-chief of @CR_AACR Alvin and Shigeaki @haochenz39 teammates at #IacobuzioLab

Congrats! 🎉 @haochenz39 rocking 🎸 his talk on single cell DNA sequencing in #PancreaticCancer #AACR Shigeaki, Haochen, Elias, and I from @ciacobu @CpcrMsk lab have posters. Check out Elias’, Shigeaki’s and my posters (1517, 1241, 6421) ok single cell analyses! @MSK_DeptOfMed

Recently published: @haochenz39 and @ciacobu @CpcrMsk et al. present an optimised approach for snap-frozen tissue #SingleNuclei DNA #sequencing and use it to study #PancreaticCancer #clonalevolution #CancerResearch #SingleCell @natrescancer doi.org/10.1038/s41467…

@CentralParkWMD @Lamborghini

I don’t always ride a yellow cab in #NYC but when I do, I prefer @Lamborghini my friend. #staythirsty

@MDKinnz @NatureComms @ciacobu @CpcrMsk Thanks Mike! Hope all is well

@haochenz39 @NatureComms @ciacobu @CpcrMsk Congrats @haochenz39!!!

Excited to share my first first-author paper in ⁦@NatureComms⁩! We present proof-of-principle application of high-throughput single-nucleus DNA sequencing to archival samples. More exciting science to follow… ⁦@ciacobu⁩ ⁦@CpcrMsk⁩ nature.com/articles/s4146…

Absolutely stellar talk on this work from @CharlesSwanton at #ESMO22! Rethinking the balance between mutation vs environmental exposure in cancer bbc.com/news/health-62…

@ciacobu Wow!!

I have news. It's not science related, but it is quite awesome. The short version is I started making art during the pandemic and 2 yrs later I am being represented by Agora Gallery in NYC. You can see my work here: art-mine.com/artistpage/chr…