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Announcing BioMCP, a biomedical research MCP server that wraps public APIs for clinical trials, pubmed articles and genomic variants.
MIT license, more info below.
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Ian Maurer 🧬
1.7K posts
Ian Maurer 🧬
@imaurer
CTO @GenomOncology #genomics #precisiononcology #nlp
Cleveland, OH Katılım Kasım 2008
1.5K Takip Edilen1.6K Takipçiler
@MaziyarPanahi @mitsuhiko It's almost like people like to curry favor with those that have perceived power.
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@mitsuhiko ~60k people starring that repo. i don't get it!
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It works in conjunction with thinking mode, which has web search.
My pattern is:
1. Think on topic A, B, C. It searches and generates "primers" for me.
2. Then switch over to Pro Thinking and ask it to munge it all together and answer a really hard problem.
After flipping this:
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@MaziyarPanahi @emollick Sorry, yeah, it's not a different model; it's on MAX reasoning for sure.
It'll just cook for 30 minutes sometimes.
And the depth of thought is obvious.
I'm just not smart enough to need it more than two or three times a week.
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GPT-5.4 Pro continues to be the only model of its class. For anything really hard & complex, I throw it into the maw with every bit of context I can think of. More often than not, something very useful comes out.
I can't get the same results from Codex or Code or anything else.
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@MaziyarPanahi @emollick gpt-5.4 xhigh is the best do stuff model.
GPT-5.4 pro is the smartest model.
Opus 4.6 is the best talk through it with you model.
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@emollick is gpt-5.4 Pro the same as gpt-5.4 xhigh in codex?
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I think the funniest recent interaction was standing in line for coffee in SF and someone stops and goes "WAIT. WAIT HERE." (no other context yet). I'm in line so I'm not going anywhere. He runs back with his open laptop to show me Ghostty riced the fuck out. It was beautiful.
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@dbreunig Book it. Solved definition. Now that person should do “agent”.
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"slop is something that takes more human effort to consume than it took to produce."
Perfect: bsky.app/profile/schwar…
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@badlogicgames @nicopreme Clankers Works Administration (CWA) approved en.wikipedia.org/wiki/Make-work…
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People of pi. I'm going to break the extension API hard. Specifically, business logic (event handlers, custom tools/compaction/etc.) needs to be split off from the ui layer.
it will likely not be a massive amount of work to migrate an existing extension, but it will hurt a little.
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@MaziyarPanahi I'm probably older than you.
My childhood editor was Commodore 64 default editor and then I upgraded to Turbo Pascal in the early 90s lol.
Both of those were in the terminal.
So I'm back baby.
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@imaurer damn!!! all of our childhood memories are gone! 😂
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i cancelled cursor 3 months ago and went back to vscode. last week i closed all 12 vscode windows. realized i hadn't touched any of them.
20 years of IDEs. NetBeans. Visual Studio. IntelliJ. VSCode. Cursor. all replaced by a terminal.
who else killed their IDE this year?
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@daniel_mac8 @NoPriorsPod Glad we both agree we are smarter than Andrej lol.
But I also ran remote teams 12 hours away with lower skills than gpt 3.5 turbo and I got code done using upwork devs a couple times to try it out.
All easy mode compared to those really awful approaches.
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@imaurer @NoPriorsPod Same here.
I thought original GitHub Copilot was pretty damn useful 😂
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karpathy on Dwarkesh in Oct. '25:
> AI agents don't work
> They are not intelligent enough
> They are not multi-modal enough
> They can't do computer use
karpathy on @NoPriorsPod in March '26:
> AI agents fail but it's a skill issue for the humans
> You didn't give them the right instructions
AI agents absolutely hit an inflection point in December of 2025 and there's no looking back.
Haider.@slow_developer
Andrej Karpathy says when AI agents fail, it's usually a skill issue, not a capability issue You didn't write good enough instructions, didn't set up the right memory tool, or didn't parallelize correctly "the real shift is working in macro actions" One does research, one writes code, one plans, all running 20-minute tasks simultaneously
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@karpathy Great episode.
Claude made a summary gist to feed to my assistant working on my own auto research inspired orchestration for ideas.
gist.github.com/imaurer/ef57c1…
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Thank you Sarah, my pleasure to come on the pod! And happy to do some more Q&A in the replies.
sarah guo@saranormous
Caught up with @karpathy for a new @NoPriorsPod: on the phase shift in engineering, AI psychosis, claws, AutoResearch, the opportunity for a SETI-at-Home like movement in AI, the model landscape, and second order effects 02:55 - What Capability Limits Remain? 06:15 - What Mastery of Coding Agents Looks Like 11:16 - Second Order Effects of Coding Agents 15:51 - Why AutoResearch 22:45 - Relevant Skills in the AI Era 28:25 - Model Speciation 32:30 - Collaboration Surfaces for Humans and AI 37:28 - Analysis of Jobs Market Data 48:25 - Open vs. Closed Source Models 53:51 - Autonomous Robotics and Atoms 1:00:59 - MicroGPT and Agentic Education 1:05:40 - End Thoughts
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@imaurer @TheAhmadOsman Can you delete this? I really don’t want zig to somehow be bought out by a lab and have to learn another language, lol.
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you can see how OpenAI is building around Python + UV while Anthropic is building around TS + Bun
OpenAI Newsroom@OpenAINewsroom
We've reached an agreement to acquire Astral. After we close, OpenAI plans for @astral_sh to join our Codex team, with a continued focus on building great tools and advancing the shared mission of making developers more productive. openai.com/index/openai-t…
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A year ago, @OpenMed_AI didn't exist.
Open source isn't just a philosophy. It's a compounding machine.
Full report by @huggingface:
huggingface.co/blog/huggingfa…
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OpenMed is the #1 most referenced organization powering open-source AI research on Hugging Face.
This is the official State of Open Source report, Spring 2026.
I started this 8 months ago.
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@cosmo25x @TheAhmadOsman That's really the only thing that engineers can do at this point: get their clankers to shave milliseconds and microseconds off their code
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