Meri Nova

I didn’t have STEM background. I didn’t know what pip install was. Heck, I didn’t speak a word of English. I grew up with my grandma in the rural part of Kyrgyzstan. My first job was selling potatoes and onions on a sidewalk at a local bazar in Bishkek. Now, I live in San Francisco. Every day, I meet the smartest and the most Influential people in Tech. My self-doubt and imposter syndrome have never been this high. 99% of the time, I am the dumbest person in the room. This slowly was getting under my skin. It was making me feel small and insignificant. I wouldn’t ask questions because I didn’t want to sound foolish. This made me stuck in one place. Until I realized, if I keep being quiet, I won’t ever grow and learn. So now, the first thing I do when I wake up is leetcode problems. I go to deeply technical meetups. I make friends with excellent engineers and scientists. And I am finally okay with looking like a fool and learning as much as I can. As fearlessly as I can. This is a reminder, to never let your environment dictate how you should feel about yourself. Instead use it as a source of inspiration to propel you forward. #leetcode #adhd #datascience #motivation #inspiration #impostersyndrome

@haithehuman Second that. Ai should democratize access to wealth. Not the other way around . Love your initiative on 15% back

instead of riding politicians' coat tails and bandwaggon-ing politics, we provide real value to enterprises and mid-markets, build agents and harnesses (because we're real builders), and put money where our mouth is (15% revenue back to the community). works out pretty well.

@ArthurMacwaters this is hands-down the best way to raise shareholder value

im dumping my 401k into Palantir because of this and I don’t care what anyone says

@bryan_johnson @haithehuman tag Leo pls. this is our next dose.

Doing magic mushrooms this Sunday. Protocol + dose: 5 grams + frequency: 1x/mo for 3 mo + objective: exploring longevity effects Measurement + 249 independent biomarkers + 29 vials of blood + brain scans + urine, stool, saliva, fertility + multi-omics profiling (DNA, epigenetics, metabolism, hormones, microbiome, proteins, cognition) Cardiovascular + LDL-C + HDL-C + Triglycerides + Total cholesterol + Apolipoprotein B + Apolipoprotein A-1 + Lipoprotein(a) + LDL-P + HDL-P + Small LDL-P + LDL size + Large VLDL-P + Large HDL-P + VLDL size + HDL size + LP-IR score + Oxidized LDL + Lp-PLA2 activity + Myeloperoxidase (MPO) + Homocysteine + VEGF Hematology + WBC + RBC + Hemoglobin + Hematocrit + MCV + MCH + MCHC + RDW + Platelets + Neutrophils + Lymphocytes + Monocytes + Eosinophils + Basophils + Immature granulocytes + Erythropoietin (EPO) + ABO/Rh typing Hormonal + Thyroid panel with TSH + Free T4 + Testosterone + Dihydrotestosterone (DHT) + 5α-DHT + Prolactin + Estradiol + LH + FSH + Estrone (E1) + Estriol (E3) + Androstenedione + Androsterone + 5β-Androstanediol + Etiocholanolone + Cortisol + Cortisone + DHEA + DHEA-S + Pregnenolone + IGF-1 + Melatonin (6-hydroxymelatonin sulfate) Metabolic + Glucose + Insulin + Hemoglobin A1c + α-Hydroxybutyrate + β-Hydroxybutyrate + Uric acid Kidney + BUN + Creatinine + eGFR + BUN/Creatinine ratio + Cystatin C + Urinalysis (specific gravity, pH, color, appearance, leukocyte esterase, protein, glucose, ketones, occult blood, bilirubin, urobilinogen, nitrite, WBC [hpf], RBC [hpf], epithelial cells, casts, bacteria) + Albumin/Creatinine ratio Pancreatic + Total protein + Albumin + Globulin + Total bilirubin + Alkaline phosphatase + AST + ALT + GGT + Amylase + Lipase Minerals + Sodium + Potassium + Chloride + CO₂ (bicarbonate) + Calcium + Magnesium + Iron + TIBC + UIBC + Iron saturation + Ferritin + Zinc Vitamins + Vitamin B12 + 25-hydroxy Vitamin D + Coenzyme Q10 + α-Tocopherol + β-Carotene + Glutathione + Total glutathione Amino Acids + Cysteine + Methionine + Taurine + Glycine + Serine + Threonine + Alanine + Valine + Leucine + Isoleucine + Phenylalanine + Tyrosine + Tryptophan Inflammation + Interleukin-6 (IL-6) + Interleukin-10 (IL-10) + Tumor Necrosis Factor-α (TNF-α) + Rheumatoid factor (RF) + ANA by IFA + Calprotectin (GI inflammation), + Secretory IgA (mucosal immunity) Neurology + P-tau217 + Epinephrine metabolites (metanephrine, normetanephrine) + Homovanillate (HVA) + Vanilmandelate (VMA) + 5-Hydroxyindoleacetate (5-HIAA) Toxicology + Lead + Lithium Urology + PSA total Fertility + Total Motile Count + Sample Volume + Concentration + Motility + Morphology + Count Metabolomics + Citrate + cis-Aconitate + Isocitrate + α-Ketoglutarate + Succinate + Fumarate + Malate + Pyruvate + Lactate + 2-Hydroxyglutarate, + Hydroxymethylglutarate, + 3-Methylglutaconate, + 2-Methylsuccinate + Formiminoglutamate (FIGLU), + Methylmalonate (MMA), + Xanthurenate + Kynurenate, + Quinolinic acid + Glucarate, + 8-Hydroxy-2′-deoxyguanosine (8-OHdG), + Pyroglutamate + 3-Hydroxyphenylacetate, + 4-Hydroxyphenylacetate, + 2-Hydroxyphenylacetic acid + 4-Cresol, + p-Hydroxybenzoate, + Benzoate, + Hippurate/Hippuric acid + Phenylacetate/Phenylacetic acid, + Indoleacetate/Indoleacetic acid + Arabinose, + Citramalic acid, + α-Hydroxyisobutyric acid Microbiome + Bacteroides fragilis + Bacteroides vulgatus + Faecalibacterium prausnitzii + Akkermansia muciniphila + Roseburia spp. + Eubacterium rectale + Lactobacillus spp. + Bifidobacterium spp. + Escherichia coli + Clostridium difficile + Enterococcus faecalis + Candida albicans + Saccharomyces boulardii + Prevotella copri + Ruminococcus spp. + Methanobrevibacter smithii + Blautia spp. + Proteobacteria spp. + Firmicutes/Bacteroidetes ratio + Beta-glucuronidase + Butyrate + Propionate + Acetate Aging & Epigenetics + Telomere length + Relative telomerase activity + DNA methylation age + DNA methylation levels at CpG sites associated with biological aging + Glucocorticoid receptor methylation (NR3C1) + SIRT1 methylation + MTOR methylation + Oxidative stress response genes (NFE2L2 promoter methylation) Cognitive + Brain age score + Functional connectivity strength + Global connectivity index + Hemodynamic response amplitude + Hemodynamic response latency + Resting-state oxygenated hemoglobin (HbO) concentration + Resting-state deoxygenated hemoglobin (HbR) concentration + Total hemoglobin (HbT) concentration + Oxygen saturation (O₂Sat) + Cerebral blood volume (CBV) + Cerebral blood flow (CBF) + Neurovascular coupling index + Prefrontal cortex oxygenation + Parietal cortex oxygenation + Temporal cortex oxygenation + Occipital cortex oxygenation + Task-evoked hemodynamic response (HbO/HbR) + Temporal autocorrelation of hemodynamics + Functional brain network modularity + Inter-regional coherence + Brain lateralization index + Oscillatory power (slow cortical fluctuations) + Phase synchronization index + Mean reaction time (during cognitive tasks) + Reaction time variability + Heart-rate variability (HRV) + Resting heart rate

@calcsam the pie is too big and its growing. This is how healthy competition looks like. HOW was the Conference???

Business is sports, not war. War is pure zero-sum. In sports, teams and players compete hard but can change sides, maintain friendships, and learn craft from each other. Yesterday at Mastra we hosted the first TypeScript AI conference. In the keynote, we shouted out three different competing agentic UI frameworks, each of which sponsored the conference and demo-ed their products. Nico Albanese from Vercel came to talk about the AI SDK. Over the last few months they've started doing some things that we do, and we've starting doing some things they do. We were grateful to have them: they're an important part of the TS AI world. Before his talk Nico and I were chatting outside the speaker lounge and he was telling me about the things he learned working with Lee Robinson. Lee is someone I've long admired whose work we got to see a lot back in the Gatsby vs. Next.js days. In the afternoon I did a panel with Marc Klingen from Langfuse and Jason Lopatecki from Arize, each CEOs of leading AI observability companies. They frequently compete in deals. Before, after and during the panel Marc and Jason were having a collegial discussion about the state of the industry, and the ways in which their companies, products, and philosophies were similar and differed. I've been doing open-source devtools for a decade, startups for a decade and a half. In devtools, your integrations are your partnerships, and often your friendships too. At the end of the day, we're building things that haven't been built before, and pushing the state of technology forward together. Life is long, and I'm here building because I want to play infinite games with my friends, my partners, and my competitors.

@jxnlco This is hilarious

eng manager: our team uses cursor!! me: I pair programmed with 4 of your engineers last week, they literally just use it as an ide.

I just released Beads, a drop-in cognitive upgrade for your coding agent of choice. github.com/steveyegge/bea… In a nutshell, it is a magical 4-dimensional graph-based git-backed fairy-dusted issue-tracker database, designed to let coding agents track all your work and never get lost again. Beads replaces that disgusting pile of half-eaten markdown files in your plans/ directory. You know you have one. Install the Beads binary, tell your agent in AGENTS.md to stop using Markdown and run `bd quickstart`, and your agents will spontaneously get better at everything, particularly long-horizon planning and keeping track of newly discovered work. If you are looking for a long-ass but occasionally funny article about how I discovered it while burning a 350k line code base to the ground: steve-yegge.medium.com/introducing-be… Or you can, you know, just start using it. It's MIT-licensed, written in Go, and super lightweight and portable. Let me know how you like it. Enjoy!

@benhylak Ben, dude. This was an insightful read. Evals are becoming so meta. You mentioned you have trained models that “pluck” those edge cases. Can you elaborate more? And how can we define what is “bad” to look out for?

i just wrote my first long-form post on evals. what they are, where they work, where they don't, and what i think the future looks like. if you're building an ai product, you should read this.

Claude Code: no evals [well known code agent company]: no evals [well known code agent company 2]: kinda halfassed evals [leading vibe coding company]: no evals [ceo of company selling you evals]: mmmmm yess all my top customers do evals, you should do evals [vc's in love with ceo of evals company]: mmmmm yes all my top founders do evals, must do evals (NOTE: i -do- also think that evals are impt, but the eval pilled ai engineers have also noticed that it is not a strict requirement for success and, at least for 0-to-1 stage, may even be anticorrelated, think thru why)

@AlexReibman @X Enjoyed the read. But was the announcement a satirical joke? Or you actually releasing evals 😭

@X Thanks for making it this far. Follow/subscribe to my newsletter if you enjoyed :) Evals Delenda Est

Evals are a scam. And we're being gaslit into believing they aren't. New post just dropped (🧵).

@haithehuman Dude, I thought I was being more X here 😂

@intelligentle__ get that LI shiii outta hereee

I'd rather have a great team than a great product. The latter will always follow if you have the right people.

@calcsam LOVE THISSSSS.

proud to share that we're hosting the first-ever typescript-first AI conference this nov in sf this is the place to meet other builders.....or be part of it all remotely x.com/mastra_ai/stat…

@JamesEbringer M

Forget building a brand I use AI to drop 500 posts/day in 13 mins No face, no ads, no fluff 100M+ views on autopilot Comment “M” and I’ll DM you the system (must be following)

@haithehuman @braintrustdata @aiDotEngineer vuaahahahah

I'm still not adding evals (@braintrustdata at the @aiDotEngineer )

@dzhng a browser agent insteaad ?

Pretty convinced now that the long term sticky coding agent will NOT be yet another VS code wrapper/extension

- create custom evals - implement guardrails - have a human in a loop - write tests before code - ditch Streamlit, learn Typescript And you are golden, baby. #AIengineer

Please, stop building RAG projects! If you want to succeed as an AI engineer, focus on this instead: - solve a real problem - build a simple agent - scrape the web - retrieve your data - call another API

@haithehuman This will be huge

On 2/24, I'm doing a launch week for Cats with Bats I'll highlight an aspect that makes it the definitive place for dev content creators (DevRel, DevEd, solo creators) The future of dev work is with coding agents, so dev education must work with agents. Stay tuned!

@tunguz You confused everyone here 😂

Don't worry, pretty soon tech companies will have NO employees of any kind.