Ioannis Xenarios

We acquired a large-scale mixed-species benchmark, with variable background, to comprehensively assess quantitative accuracy of proteomics. Key features: - 192 runs, 0.75ng - 15ng of variable human cell line backgroud. - Can dissect the impact of both random and systematic errors. - Can test how quantitation algorithms scale with experiment size and sample heterogeneity. Our insights based on the data: biorxiv.org/content/10.648…. PRIDE repo will be made public in the next days.

Join us as a colleague! Our Dept. of Plant Mol. Biol. is recruiting a Tenure-Track Assistant Professor in the thematic area of Plant–Organism Interaction (incl. bacteria, fungi, insects, other plants).🦠 🦗🌱 See the official job advertisement for details: career5.successfactors.eu/career?career%…

The emerging "nudge era" of cancer treatment based on multiomic profiling, spatial biology cell.com/cancer-cell/ab…

⚡️ Don’t forget that we’re looking for a Tenure-track Assistant Professor in Quantitative Cell Biology @unibern 🔬 Bridge experiments + theory 📈 Tackle processes across scales 💡 Join our vibrant research community Deadline Oct 17 👉 shorturl.at/1Y1WP

Join us for the upcoming 7th Annual HPC-AI UK Conference. Agenda is live and we look forward to a wonderful 2-day deep dive on trustworthy compute. dirac.ac.uk/hpc-ai-advisor… #hpc_ai_uk2025

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl is hiring in AI. embl.wd103.myworkdayjobs.com/en-US/EMBL/job…

Hey researchers! DYK that All of Us participants can contribute info from their wearable devices, like Fitbit? Biometric data such as heart rate, physical activity, & sleep, can be combined with genomic data for new insights. Learn more: allof-us.org/462t549

Today marks the 10th anniversary of Genomics England's PanelApp! This gene-disease knowledge base allows experts to share their knowledge of rare conditions and cancer. Currently, there are over 400 publicly available gene panels in PanelApp. Read more: genomicsengland.co.uk/panelapp

The CDC attack is a wake up call. Not just about security, but about truth. About restoring shared reality to our discourse. About valuing our health and public health workforce. About standing with the people who protect us. About the simple principle that should guide all systems: Safety first. tomfrieden.substack.com/p/the-cdc-atta…

WORK! My lab currently have 5 (!) open positions for postdocs/PhD students for: -Nanopore protein sequencing -Archaeal CDV cell division -Microfluidics for synthetic cells -Nuclear Pore Complex -Origami mimics of peroxisomes Please apply! ceesdekkerlab.nl/come-join-us/ RT=👍

The EPFL NLP lab is looking to hire a postdoctoral researcher on the topic of designing, training, and evaluating multilingual #LLMs. (link below) Come join our dynamic group in beautiful Lausanne!

Data from the second human treated with a prime edited medicine: a 56-year-old male with chronic granulotamous disease (CGD) had his bone marrow prime edited to insert the missing GT in NCF1, restoring NADPH oxidase function in neutrophils (DHR positivity) several fold beyond the therapeutic threshold. His intestinal inflammation is now normal, and his prime-edited HSCs rapidly engrafted with 15 days post-transplant, consistent with well-tolerated editing. Each new therapeutic technology is dependent on brave patients willing to be among the first humans to receive a new type of treatment. For prime editing, that's this patient, and an 18-year old who also responded in a similarly encouraging manner. Patient #2 sent our lab a kind message, noting that helping other patients with rare diseases was deeply meaningful to him. Data from @PrimeMedicine.

🚨Open position alert! Seeking a Junior Group Lead in #Computational Biology to join #TeamIHB and establish an independent research programme in computational morphometry of human model systems. More at go.roche.com/v3ovw #computationbiology #ScienceJobs

Monumental review !! A must-read !

"Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair" nature.com/articles/s4159… congrats to the @WeillCornell lab team, Justin Zook, and @NIST for this key resource!

The authors also use TAP(app.tamarind.bio/tools/tap) to evaluate the developability of the generated sequence in silico, and find that the vast majority pass the developability threshold compared to clinical Abs. Read more from the team's preprint: biorxiv.org/content/10.110…

We retrospectively analyzed the reproducibility of 400 papers in the field of #Drosophila immunity. Irreproducibility was rather low. High-impact journals, top institutions and PI training influence replicability levels. #Reproducibility #LifeSciences

When #AlphaFold2 came out, we wondered: Could it help us understand how enzymes evolve? So we tried it—and it worked! nature.com/articles/s4158…

We are seeking a Scientific Database Curator at @emblebi in collaboration with the @saezlab and @GSK. This role involves wrangling public transcriptomic data - bulk, single-cell, and spatial - for translational use and integration into our open data resources Deadline 20 July

Gene therapy cures genetic deafness for the first time - in kids AND adults. One injection restored hearing in 10 people aged 1.5 to 24 years, reports @NatureMedicine Here's how 🧵