J David Warren

With fear for our Democracy, I dissent.

If you’re covering Biden’s age issues without also acknowledging that Trump fell asleep and drooled on himself *every day* he was in court — or that he often didn’t start working until noon when he was in the White House — you aren’t being honest with the American people.

@DirkTrauner @nyuchemistry @aroralabnyu Congratulations, my friend! A well-deserved honor.

Congrats to Paramjit Arora for getting the Ralph Hirschmann Award! Way to go, Bobby! @nyuchemistry, @aroralabnyu

"Firearms accounted for nearly 19% of childhood deaths (ages 1-18) in 2021" Interestingly, that's higher than the share of deaths due to childhood cancer yet ads raising money to prevent/Tx gunshots would likely be viewed as purely political... cnn.com/2023/08/08/us/…

BREAKING: Legendary actor Samuel L. Jackson brutally rips into Donald Trump in an explosive new interview with Rolling Stone. The brilliant tirade started with Jackson explaining that he was a "child of the Sixties" and he "grew up in segregation." Jackson says that some of the racists would hide it, but "they don't hide it anymore." "I know how the Republicans feel about me now because of what my mindset is," he said. "When I see Trump, I see the same rednecks I saw when I was growing up who called me “n***er” and tried to keep me in my place," Jackson went on. "That’s what the Republican Party is to me. They’re doing it to young people, gay people. They don’t care who you are. If you’re not them, you’re the enemy." MAGA fans are absolutely furious and already vowing to never watch any more Samuel L. Jackson films. Apparently, the truth hurts. RT and ❤️ if Jackson nailed it — and consider investing in Tribel, a “woke” new Twitter competitor that is currently doing a round of equity crowdfunding and just blew past $1.4 million raised from 3,600 of its users. If you want to own a small piece of what is quickly becoming the “next big thing” in social media, here is the link to do so, wefunder.com/Tribel. You can invest as little as $100 — or as much as you’d like. Here’s the link to download the new Tribel app that Elon Musk is so afraid of: tribel.app.link/okwPIHYCIqb

🚨🚨🚨 Holy shit: A group of parents in Tennessee are OUTRAGED that a local school board caved to a conservative group and cancelled a librarian’s Mother's Day lesson inclusive to kids without moms. The parents boldly confronted the Hamilton County School Board and held nothing back: One dad said, “This is 2023. I'm a Christian man, married to a woman, but I think everyone should be represented fairly. If you want to keep your kids in a closet and just shelter them from everything, homeschool them. Send them to Christian school. This is a public school for everyone. Everyone. I've dealt with that woman. She loves these kids.” The organization Moms for Liberty is a right-wing organization that campaigns against social progress and civil rights. They target local school board meetings and has deep connections to the Republican Party. Moms for Liberty also promoted stripping districts of protective COVID-19 measures and are bad news. Thank you to these brave parents for speaking out! 💙💙💙

@Rockies @PJStiz @bruter24 Too bad we’ve already been mathematically eliminated from the playoffs.

New season, new faces 🙂

@johnnyxbrown @liftyourmind 2023

I built a killer habit tracker for 2023 ⚡️ For the next 24 hours, I am giving it away for free! You can use this template to track your daily habits and visualize your progress. Reply "2023" below, and I'll DM you the link! Must be following @johnnyxbrown to receive.

2022 Novel Small Molecule Drug Approvals There were 19 novel small molecule drugs approved by the FDA in 2022 - read more about their discovery, mechanisms of action, and differentiation and download the hi-res poster here: drughunters.com/3GxrXed #chemistry #medicine

The Molecular Glue Degrader Landscape in 2022 | drughunters.com/3vhRHof Dive into molecular glue degraders and where this field might be headed in our latest review with the @CASChemistry team #drughunter

Insurrectionists like Gosar, Greene, and Boebart shouldn't serve in Congress. Members of Congress can object to them from being sworn into Congress on January 3 - and they should. It’s their constitutional duty. Sign this petition if you agree: sign.moveon.org/petitions/the-…

Drug Discovery Strategies to Optimize Unbound Brain Concentrations in CNS Infectious Diseases, with Dennis Koester | lu.ma/w1q906iz December 8th, 1:00pm EST Presenting in silico, in vitro, and in vivo tools to assess, predict, and optimize brain-partitioning.

Small Molecule PI3K Inhibition in Oncology: What's Been Done and What's to Come? | drughunters.com/3TBF6Gi We reviewed the history and current status of PI3K inhibitors, including their approval history, resistance mechanisms, and the next generation of PI3K Inhibitors

Saw a Forbes article recently claim that 23 clinical candidates were in development from AI/ML. What do these molecules look like and what do they target? The team's latest Premium report - try it here: drughunters.com/TW-trial

Hope to see you there!

The Landscape of AI/ML in Drug Discovery | drughunters.com/AIML1 The application of AI/ML methods to drug discovery has been an area of significant investment for at least 10 years now. This three-part Drug Hunter special on AI/ML in drug discovery summarizes the field.

How Does This Thing Get in the Brain?? | drughunter.com/how-does-this-… At AAPS 2022, I hosted a symposium where Ovoca Bio plc’s Head of Research told us about orenetide. Orenetide is an internationally approved drug for hypoactive sexual desire disorder (HSDD) (think Viagra for ♀️)...

Stable Atropisomers in Drug Discovery via Catalysis | drughunters.com/3Wor1yy Examples of development candidates that are stable atropisomers, synthesis, and a kilo-scale synthesis of a Ph. III candidate using asymmetric catalysis in this article with the team at Sinocompound

Sept 2022 #MoleculesOfTheMonth | drughunters.com/MoTMsept22 No time to read before your next team meeting? Grab a coffee and check out these molecules. Get a free trial at drughunters.com/join-TW to get access to the full reviews, structure search, novel drug coverage, and more.