Josh Backman

71 posts

Josh Backman

Josh Backman

@jdbackman

Statistical Geneticist at Regeneron Genetics Center. Fan of science, my dog, and the Dallas Cowboys. Opinions my own.

Katılım Mart 2019
170 Takip Edilen201 Takipçiler
Josh Backman
Josh Backman@jdbackman·
We're hiring a Manager, Analytical Genetics to support growing efforts in large-scale proteomics at the RGC. Are you interested in applying machine learning to develop prediction models for age-related diseases? Apply below! careers.regeneron.com/en/jobs/r40672… via @regeneron
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Regeneron Genetics Center
Regeneron Genetics Center@RegeneronDNA·
With ~1M exomes sequenced, we published the largest set of human protein-coding variation to date today in @Nature. RGC-ME data contains genetic variation from individuals of African, American, South and East Asian and Middle Eastern ancestry.
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Josh Backman
Josh Backman@jdbackman·
We are still looking for a statistical geneticist to help drive our efforts in rare diseases! Reach out or apply at the link below if interested! careers.regeneron.com/NzJTjLq
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Jonathan Marchini
Jonathan Marchini@marchini·
Very excited to share our paper on genetics of the MCPS. Before you dive in a key point to highlight : from 1998-2004 our @UIME_UNAM & @Oxford_NDPH colleagues had the vision to conceive the study, and then visit >100,000 houses in Mexico City to recruit 150,000 participants 🤯
Regeneron Genetics Center@RegeneronDNA

Hispanic/Latino individuals are represented in <1% of #GenomicResearch. To reduce this diversity gap, the Mexico City Prospective Study (MCPS) research team conducted the most extensive sequencing study in individuals of non-European ancestry to date. #RGCResearch

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Regeneron Genetics Center
Regeneron Genetics Center@RegeneronDNA·
Congratulations to our very own, @joellembatchou, Ph.D., Manager of Statistical Genetics, as she was recognized as one of @FierceHealth and @FierceMedTech's rising stars in health tech! Join us in giving her a round of applause 👏 and read more about her inspiring work.
FierceHealthcare@FierceHealth

It is increasingly obvious that the line between traditional meds and tech-enabled healthcare companies has been blurred. So this year, we’re highlighting 17 rising stars in the health tech world who are doing their part to further erase that line. tinyurl.com/yts4pumb

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Josh Backman
Josh Backman@jdbackman·
Our team is hiring! Are you a statistical geneticist with an interest in rare disease genetics, family-based analyses, and/or working with sequence data from diverse and understudied populations across the globe? Reach out or click below to learn more careers.regeneron.com/l4~wCVo
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Josh Backman
Josh Backman@jdbackman·
@Bun_Without_B @Nature Thanks for the read! We did not do a missense only gene burden. That wouldn't be quite right, since there are plenty of genes in (1) that would provide missense only results, if tested. You should be able to generate a version of missense only gene burden tests via the UKB RAP.
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An Hoang
An Hoang@Bun_Without_B·
@jdbackman @Nature Thank you for the great paper! Do you by any chance have gene burden test result for just missense variants? I see you have gene burden results for (1) "pLOF only" and (2) "pLOF + missense". Should I just do genes that are in (2) and not in (1)?
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Regeneron Genetics Center
Regeneron Genetics Center@RegeneronDNA·
Our recent genome-wide analysis shows that levels of the ACE2 receptor influence COVID-19 risk. A genetic variant near the ACE2 gene decreases levels of the SARS-CoV-2 gateway receptor by 37% and infection risk by 40%. Read more about our recent discovery in @NatureGenet.
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GenScript
GenScript@GenScript·
A #LandMark achievement in the history of human #Genetics ! Scientists from @RegeneronDNA have uncovered hundreds of genes that contribute to different traits and diseases👏👏👏! Thanks to all the authors for lighting up our #genome👍👍👍@jdbackman
Regeneron Genetics Center@RegeneronDNA

Read our paper on the exome sequencing of 454,787 @uk_biobank participants, published in @Nature. Our scientists continue to push the boundaries of genomics. Their work lights up our genome!

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Keşfet

@Regeneron @Nature @UIME_UNAM @Oxford_NDPH @joellembatchou @FierceHealth @FierceMedTech @RegeneronDNA