Jerrin Thomas George

I am happy to share our work on the mechanism of prokaryotic immunity by a reverse transcriptase associated with an SMC-family ATPase, now published in @NatureComms!
🔗 nature.com/articles/s4146… (🧵 on the bioRxiv version ⬇️)

Druantia, Druantia, Druantia, Druantia🔥🔥🔥🔥 biorxiv.org/content/10.648… biorxiv.org/content/10.648… biorxiv.org/content/10.648… biorxiv.org/content/10.648…

Happy to share that our work on Cas12a2 was published in Nature last week. USU Biochemists Show CRISPR Can Selectively Destroy Cells, a Cancer-Treatment Goal usu.edu/today/story/us…

1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. doi.org/10.64898/2026.…

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/sc… 🦠🧬🛠️🖥️💥

Bridging continuous and discrete evolution through a controllable, hypermutagenic phage-bacteria system dlvr.it/TSKLBs #MicroSky

Our lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.

Phage community: our plasmids for executing phage transposon mutagenesis are now on AddGene and I would love for you to try it out! It is powerful for ID'ing all essential genes and knocking out all non-essentials in a single experiment :) New exp here: addgene.org/browse/article…

Out now in @NatureBiotech! @alex_gonzadel and a fantastic team of collaborators worked across nine labs to get retron-mediated recombineering up-and-running in fifteen bacterial species. Molecular parts are on addgene: addgene.org/browse/article… Happy editing!

» Genome editing of phylogenetically distinct bacteria using cross-species retron-mediated recombineering | Nature Biotechnology nature.com/articles/s4158…

PostDoc position available! (links in post below) Feel free to share!

‼️Please share‼️   Nemudryi lab is looking for postdocs to join our team and study:   🦠 Bacterial phage defense   🧬 RNA repair & CRISPR-based RNA editing   Excited about RNA, host-virus interactions & mechanistic biology?   Let's talk!   Apply: explore.jobs.ufl.edu/en-us/job/5394…

How do you kill a MRSA superbug armed with 15 defense systems? You engineer a smarter phage. Check out the Modell lab's preprint on overcoming bacterial immunity via defense-guided engineering to build durable therapeutic phage cocktails! Led by Sarah Voss doi.org/10.64898/2026.…

Precise, minimally evolved adenine base editors generated through mutation reversion analysis go.nature.com/4rHWkmu

Single-molecule peptide sequencing through reverse translation of peptides into DNA go.nature.com/4sRPr2K

Download our extended database of postdoc fellowships. 276 funding opportunities. For each entry, we provide eligibility/requirements, amount, deadline, link, description, etc. Download our database here: research.jhu.edu/rdt/funding-op…

New preprint from the Sternberg lab!  biorxiv.org/content/10.648… We used pooled oligonucleotide library mutagenesis + high-throughput sequencing to systematically dissect the molecular determinants of IStron transposition, RNA-guided DNA cleavage, and self-splicing.

Our work on bacterial Schlafens in phage defense is out today @NatureMicrobiol ! Check out the final version here: rdcu.be/e7Bmz We are looking for postdocs and students to expand our team! Official postings are coming soon. Please reach out if you're interested!

Out now! In collaboration with @LeifuChangLab, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems! Links to the articles in the following tweet:

New post-doctoral research position available in my Phage-host interactions (Phi) laboratory at the @otago in the Department of Microbiology and Immunology. The project is focused on defences against jumbo phages. Please share and if interested apply using the link below.