Juan Carlos Garcés

Last month Salesforce announced it would open its APIs and launch a headless product, essentially betting that in an agentic world, its value lies in the data layer, not the UI. The announcement is a useful prompt for a more interesting question: if you strip away the UI and expose the database, what are you actually left with? a16z's Seema Amble on where defensibility moves in the agentic era & how businesses will adapt: a16z.news/p/is-software-…

I’ve always believed the No.1 application of AI should be to improve human health. That work started with AlphaFold, and now at @IsomorphicLabs with the mission to reimagine drug discovery and one day solve all disease! We are turbocharging that goal with $2.1B in new funding.

Qué tensión más elocuente y perturbadora. Una transformación incomprensible de una mujer que empuja a los límites de la tolerancia a quien se aproxima a ella. Estética y extraña obra que se cuela en los sueños.

Misma emoción que cuando descubrí a Lemebel. Una bizarrísima joya gauchesca que encontré por azar e incomprensiblemente no tenía bajo mi radar hasta ahora. Un imprescindible para los amantes de lo surrealista. Qué forma de disfrutar semejante derrame de autenticidad.

Retomamos en 2026. Al final acabo agradeciendo escribir una mínima frase que sirva de disparador para el recuerdo.

We’ve agreed to a partnership with @SpaceX that will substantially increase our compute capacity. This, along with our other recent compute deals, means that we’ve been able to increase our usage limits for Claude Code and the Claude API.

The hyperscalers have already outspent the most famous US megaprojects

Boris Cherny (Creator of Claude Code): "The one technical book I would recommend to everyone that has had the greatest impact on me as an engineer is functional programming in Scala. You're probably never going to use Scala day today, but the way it teaches you to think about coding problems is just such a change from the way that most people were in coding, either practically or in school. It's just. It's incredible. It's going to completely change the way that you code now. I think in types, when I code, the thing that matters in your code the most is the type signatures. This is more important than the code itself." @bcherny

Anthropic y Google*

Mientras xAI y OpenAI se pelean, Anthropic entrega 🚀

@DavidPombar "El remoto se ha acabado" 🥸

Los programadores se van a ir al paro!!! XD

The founder of Postman says you have to kill your existing org chart, especially if you're still operating with a pre ai hierarchy arrangement. The modern org chart, according to @a85: - wide span of control (even within exec team) - work directly with ICs, not through layers - either you're building, or you're selling Projects are led by staff/principal engineers with high agency. They see across the board as well as deep in the stack. Product managers are building APIs and prototyping in Claude instead of writing PRDs. Designers are shipping PRs through Cursor directly instead of relying solely on Figma. Everyone is building. And the management's job is to develop better judgment.

Every time I watch one of these clips, I keep thinking about how these boys are actually older here than they were when pressing buttons for Doge and ripping vital agencies apart. And then I think about how young they must have been when Peter Thiel or Elon found them and groomed them to do their bidding. And then I think about alllll the communication between Peter Thiel and Epstein and Elon begging to go to depraved Epstein island parties. And then I throw up.

White Collar Goes Blue, by @anuatluru open.substack.com/pub/anu/p/whit…

$25 per PR review The frog is starting to boil

People saying AI is not there yet for generating code are probably those that spent years discussing tabs vs spaces, linting rules, number of lines in a function and called their naming conventions “software architecture”

the most underrated hire right now is a great product person. when i say product person i'm def not talking about a product manager. perhaps i think there has to be somewhat of a new role. i don't have a good name for it yet but maybe something like "product thinker".. someone with an intuitive grasp of the product as it exists, where it's soft, where it sings, & how to iterate it toward something even sharper. in some sense, this person has to cohesively hold in their head where this product should be 2 years from now & work backwards from that. i say this cuz when building was hard, engineering was the bottleneck & the status hierarchy often reflected that. building is no longer hard. which means the variance in outcomes has shifted almost entirely to judgment on what to build, how to sequence it, & how to talk about it. & the story matters as much as the thing. internally, it organizes the team around a shared model of why. externally, it shapes the interpretive frame users bring to their first experience. you can't retrofit narrative onto a product & expect it to land, it has to be load bearing from the start. the rarest version of this person sits at the intersection of culture & deep technology. someone genuinely bilingual. they know what's technically possible & they know which cultural currents are real vs. ephemeral. that combo is what separates products that feel inevitable from products that feel assembled. before ppl clap back with this person has always been valuable, i know.. i am just saying now they might be the most *important* person in the room. their value compounds like never before.

spotify. klarna. mistral. ledger. doctolib. blablacar. criteo. skype. revolut. deepmind. arm. adyen. booking. zalando. ubisoft. deezer. king (minecraft guys). wise. bolt. zendesk. and like half of them either went through epitech (so did i) or were founded by people who did lmao europe invented the startup ecosystem that silicon valley then gentrified. the problem isn't the region it's brain drain