Jimmy

@BarryToohey Is KP kicking today mate? Is his hammy okay

Moving forward with pathways players Ben.

@Amonhohohotep @ChrisMasterjohn Yep, no way to blind 5g vs 25g. Your bowels will know 😂

@ChrisMasterjohn All I gotta say is that you better drink a helluva lotta water if you’re taking 25g, even split x3. That’s some serious disasterpants maxxing if not.

These single-dose creatine studies have SEVERE limitations for generalizing anything actionable from them. The good news is that they show that, in these subjects, both 14 grams and 25 grams of creatine in a single dose during a single night of sleep deprivation blunts the decline of logic, accuracy, and the slowing of reaction time and cognitive processing that otherwise occurs as a result of sleep loss. But people saying "you don't need to maxx!" or "take it intermittently not every day!" are reading wildly beyond the data provided and ignoring a gigantic elephant in the room. None of this group's papers state whether the subjects were habitual users of creatine. They should either be studying people who all use creatine similarly, or recent use of creatine should be an explicit exclusion criterion. But neither are true. It is incredibly OBVIOUS that the relevance of a single dose of creatine could be completely different in someone whose muscle stores are fully saturated than in someone who is naive to creatine supplementation. This clearly can play a role in how much is available to get to the brain. Further, so little is known about brain uptake that it is very possible a person who has taken 5 grams of creatine a day for a year has as much in the brain as they could ever use. It is a major oversight for them not to clearly state this. But they *imply* that these were not creatine users by saying that it has previously been shown you need to consume it for a week or longer to get a brain benefit and that the novel contribution of their study was to look at the impact of a single large dose. They mention that 9 out of 29 subjects were vegetarian and that they likely had a higher creatine demand due to lower intake, also implying the subjects were naive to creatine. But if that's the case, then it is questionable whether these results apply to people who are already long-term creatine users. How they decided to make them abstain from caffeine and alcohol before the trial and ask whether they are vegetarian yet not ask whether they use creatine is beyond me. The average creatine dose in this paper was 14 grams. This is lower than the 25 grams used in the earlier study, but it is nearly three times the typical maintenance dose. These papers offer proof of principle that creatine blunts the impact of sleep loss. They imply that if you are similar to the population they used, you may need 14 grams to achieve this effect. It is very likely the case that if you use creatine regularly, these data don't apply to you. This type of effect is PERFECT for performing a randomized n=1 experiment on yourself. Why? First, the studies from this group probably don't apply to you for dosing, but probably do apply as a general proof of principle, so n=1 can give you the data you need to learn about the dose effect. Second, the effect is shown in a single night. The new paper used a standardized washout of seven days, the older paper used a variable washout, and neither provided evidence of how long the cognitive benefit takes to wear off. However, you could study this in yourself if you wanted to, or you could just use a seven-day washout. Then randomize yourself to three trials of each dose, picking whatever you want to study. If you don't use creatine it could be useful to compare 5 to 15 to 25. If you get a friend to blind it with a similar-tasing placebo drink all the better. The big question here is whether you get any benefit at all if your creatine stores are already optimized. In that case you might want to do 25 grams vs placebo so you don't get a false negative. But the point is these papers tell us NOTHING about what someone should do if they already have their creatine optimized and certainly don't tell us small doses are better than big doses or vice versa or intermittent is better than constant.

@ChrisMasterjohn Hard to do blinding when 15 grams and 25 grams make have you running to the toilet haha

@SCWhisperer Reckon Barnett is a buy or too risky with origin? I need to get off Hau

@jimmywidman No, I’m predicting a guy with a great ppm playing minimum 60 minutes.

If you’re seriously asking yourself if you 1) Sell Jackson Ford or 2) Sit him this week Go buy a 2nd phone. Call it, and have a word with yourself.

@SuperCoachNRL Will Faulolo get dual ctw/fb? Went to FB last game, named FB Rd 11 and likely named there round 12.

Thirteen new SuperCoach duals have been locked in 🔒 LATEST ▶️ bit.ly/4delftD

@monokichan @DavidDack It's not a human's thought, it's AI.

@DavidDack That extra 0.05km isn’t distance, it’s closure. It’s making sure Strava doesn’t think you gave up at the finish line like a coward in the algorithm’s eyes

Non-runners will never get the Strava tax. The run doesn’t end at 10km. It ends at 10.05km… and you already know why.

@nd_77777 @BrianSuttererMD Big creatine... fkn lol

@BrianSuttererMD yeah i think everyone understands that lmao, you in bed with big creatine?

I want to clarify my point better: In normal physiology and conditions, creatine supplementation shouldn’t be blamed for causing whole body cramps that require hospitalization. We also have to be careful of the difference between creatine and creatine kinase. Creatine kinase (CK) is a biomarker of muscle damage and is different than creatine. CK is released into the blood with muscle breakdown and then it can damage the kidneys and cause death. This is caused rhabdomyolysis and you’ve seen it in the news with other athletes. Rhabdo occurs in athletes with intense bouts of exercise. Medical conditions and supplements can contribute to the risk of rhabdo, but creatine does not directly cause rhabdo. There have to be a lot of other contributing factors that lead to full body cramps and hospitalization. So blaming a very concerning health event on taking too much creatine means either he was taking SIGNIFICANTLY more than the label recommended AND wasn’t hydrating well AND had an intense workout. Creatine is just piece of what was probably a far more involved episode and brushing it off like it was a simple creatine dose issue puts unfair blame on what’s a very safe and well studied supplement.

@SCWhisperer Disappointed with Mikaele

I haven’t been able to watch the footy, but I had my life savings on Cowboys +1.5. I assume that won easy. What do I spend my winnings on?

@maxkshen How would you teach a novice to do this?

took me three years to learn that “dissolving“ emotion through concentration was not the same as embodying emotion underneath the need to dissolve was this fear that I would be destroyed i found that i wasn’t destroyed but expanded into vivid loving warmth

@PeterVLang They're definitely not flying under the radar

Does anybody else feel that despite sitting on top of the NRL Ladder that the Panthers are ‘flying under the radar’ a little? It’s not necessarily a bad thing, just want to get everybody else’s thoughts on this? #PantherPride

@JASeagal @nrlphysio Yes

Tuesday injury dump: Jack Wighton is expected to miss 6-8 weeks after fracturing his radius (forearm). Tyran Wishart is expected to miss 4-6 weeks with a moderate grade syndesmosis injury. Sione Katoa is expected to miss 2-4 weeks with an ankle injury. Joe Roddy is expected to miss 4-6 weeks with a broken hand.

@JordanBrighton_ @DragonsCentral Don't think Tui deserves a spot?

@jimmywidman @DragonsCentral 1. Sloan 2. Tu 3. Suli 4. Gutho 5. Val

🚨DRAGONS INJURY NEWS🤕 A recap of all Dragons injury news: - Fullback Clint Gutherson is set to be back from his hamstring injury in Round 10, however, it is unknown if he will be playing fullback or another position. - Hooker Jacob Liddle is set to be back from his hamstring injury in round 11 and David Fale has also suffered a hamstring injury and is set to be back in round 15. - Youngters Lyhkan King-Togia and Nick Tsougranis are also set to be back in round 10 and could be pushing the 17. #NRLDragons

@limitlesstack Just had my second kid with a 2yo old at home. High performance job and definitely an ADHD-adjacent brain. Will be trying this

modafinil is seriously so easy to run but everyone messes it up big time the pitfalls every noob falls into: taking it too late - half life is 12-15 hours - a 10am dose = 3 hours of lost output - and guaranteed sleep problems that night solution: set a second alarm 2 hours before your real one. pop the modafinil. go back to sleep. by the time you wake up, modafinil is fully onset. wake up turned ON. sleep issues pushed back by 2 hours. skipping choline - modafinil burns through acetylcholine - no choline source leads to headache at 5pm - foggy evening - wasted second half of your day solution: 500mg citicoline in the morning. not optional. solves all of it. modafinil doesn't feel stimulatory - some people are poor responders due to CYP3A4 enzyme variation - they metabolise it too fast for plasma levels to build properly solution: switch to armodafinil. it's the purified r-enantiomer. roughly 1.5x more potent at the same dose. slower onset, longer peak. some people prefer modafinil. some armodafinil. just genetics. i love both. not drinking water - modafinil is quietly dehydrating - most of the "side effects" people complain about are just dehydration solution: 1 extra litre minimum. include electrolytes. i like to have several san pellegrino bottles on my desk. drink more if you're also on caffeine. eating too late or not at all - it kills appetite - you know this - but running it fully fasted all day then crashing into a massive meal at 8pm - destroys your sleep solution: small meal in the morning. kefir is great. eat a larger meal in the evening, but not massive. keep the brain fed. no cycling - with daily use, sleep debt compounds disproportionately by day 5-6 - by day 7 you're running modafinil on terrible sleep solution: 5 days on 2 days off. or. 3 days on 1 day off. after a few weeks. your off days feel like modafinil days anyways. making too much money: sorry, this is a natural byproduct of modafinil use, can't help with that one. solution: quit. what i actually use: us domestic modafinil modafinilxl.com/buy/modvigil-d… us domestic armodafinil modafinilxl.com/buy/waklert-do… not medical advice.

@BowTiedUM Grimhood blocked me for asking mechanistic questions about a supplement lol

GRIMHOOD HAS RETURNED And we are SHADOW BANNED AS FUCK If you are able to see this, then this message is specifically for YOU DO NOT IGNORE Check out his patreon patreon.com/posts/156467070

@antonposa Brother any idea what's going on with CNK neck?

Luai does a pretty good job on those Binge ads.

@richardgordon22 G'day Richard- i have a question about manifestations you spoke aboit in your work. To manifest an outcome do you run energy into it? How would you suggest i do this. Very interested in your work

I saw this movie when I was 16. It's one of the best movies of all time. It reveals what happens when people fight to keep that spark alive within themselves, and the culture that would extinguish it. m.youtube.com/watch?v=zpjN97…

@PhilGould15 @YouTube Gus how's Kiraz looking? Any idea how long he's out for

All Talk with Phil 'Gus' Gould youtu.be/LbTjwRf5Iu4?si… via @YouTube

@RugbyLeagueTGG @nrlphysio Great question

@nrlphysio Would playing on for 15 minutes cause further damage to an MCL injury?

Jacob Kiraz will go for scans on a suspected medial knee injury - played on for 15+ minutes after initial incident but succumbed after half time. Mechanism very similar to Payne Haas’ from yesterday - contact from tackler causing knee to collapse inwards, fairly textbook MCL sprain mechanism. Recovery time will depend on severity of the sprain - return to play range usually anywhere from 2-8 weeks.