Joel Christie

@_dm_Darshan @NatureComms @Waghmarelab @ACTREC_TMC @CRI_ACTREC @biopatrika Many Congratulations Darshan and team 👏

Delighted to share publication in @NatureComms from my Ph.D. work !✨ Forever grateful to Dr. Sanjeev Waghmare @Waghmarelab for guidance and all the contributors. Thanks to @ACTREC_TMC for support. Article in press version ! share.google/r7mnCLXcCZmTb0… @CRI_ACTREC @biopatrika

If you love the organelles that power life, come to @GordonConf Mito & Chloroplasts July 19-24, Maine. Please RT. This conference (rich tradition!) will span the evolution, metabolism, and synthetic biology of these organelles. Many oral/poster slots: tinyurl.com/5n6upfxr

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality science.org/doi/10.1126/sc…

🧠 NEW in @CellCellPress: Game-changer for biomarker development & targeted therapies. doi.org/10.1016/j.cell… #Neuroscience #AlzheimersDisease #Tauopathy #Proteomics #PrecisionMedicine #Biomarkers #Neurodegeneration #CTE #FTD #MassSpec #DrugDiscovery #BrainResearch #CellPaper

Molecular features of human pathological tau distinguish tauopathy-associated dementias: Cell cell.com/cell/fulltext/…

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects | Nature Communications nature.com/articles/s4146…

Global analysis of protein turnover dynamics in single cells: Cell cell.com/cell/fulltext/…

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

Check out our @Nature review with Tiannan Guo @guomics and Judith Steen @ionicwoman on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…

How cool is this? Michal Lipinski from @broadinstitute presenting stacked #Illumina spatial slides of the mouse brain with subcellular transcriptome resolution #AGBTGM

Mechanism of chaperone recruitment and retention on mitochondrial precursors biorxiv.org/content/10.110…

New paper alert! Heartiest congratulations to Prasanna Venkatarman lab and team members on this exciting study just out in Communications Biology @Nature @biopatrika @ACTREC_TMC nature.com/articles/s4200…

@Akshat_World The last three lines, says it all.

The last 4 years, were golden years for Indian stock investors. Not just because people made money. But, because of the fact: that people took notice of stock markets. And, really wanted to learn about it. In a low financial literacy country like India, things were finally moving. Not because of some government mandate but because of lack of options:- - Real Estate was beyond reach for most. - FD was not making sense given the high cost of living - EPF/PPF rates hardly increased since 2001 So people saw stock investing as a way to build wealth. The new taxation definitely discourages new investors in the stock market. And also highlights the point: that if retail starts making money somewhere, taxes will follow.

✨Original Article✨ 🎆The interaction network of the proteasome assembly chaperone PSMD9 regulates #proteostasis🎆 ✏️By Prasanna Venkatraman et al @CRI_ACTREC ➡️buff.ly/4akGtm7 #proteasome #proteotoxicity #unfoldedproteinresponse #aggresome

This is the first report of the novel SLiM driven interactions of PSMD9. The mutations in the Coiled Coil domain affect the interaction with motif containing proteins and affect the functional readout. (n/n)

A functional significance of PSMD9 - SLiM motif containing proteins interaction, revealed a crucial role for PSMD9 in proteostasis by influencing protein translation, suppressing UPR & modulating aggresome & lipid droplet formation. #SLiM, #lipiddroplet #proteasome, #UPR (2/n)

A part of my PhD is out as an original article @FEBSJournal. We report a short linear motif (SLiM) driven interactions of PSMD9 - a 19S Proteasome assembly chaperone. We confirm the ex vivo and in vitro interactions for some of the interacting partners (1/n)

Protein interactions are the foundation of functional and healthy cells. We @labs_mann are proud that our work for mapping the cellular yeast #interactome on a global scale is now published @nature. nature.com/articles/s4158… yeast-interactome.org #proteomics #massspectrometry

"We must show much respect and pay better salaries to our teachers and researchers. We must also provide better facilities to our researchers. We must honour them." - Narayana Murthy #InfosysPrize2023

Our mapping of the cellular protein #interactome with unprecedented depth is now published @nature. Leaps in robust #proteomics and analytic workflows enabled us to perform over 4.000 pull-downs in yeast unraveling the social and structural aspects leveraging #alphafold multimer.