Jun Axup Penman

Many good biology ideas never get tested because the researcher can't afford $2,000 in lab supplies. At @PrimordiaGrants we aim to close that gap by funding tightly scoped experiments that can de-risk impactful ideas in 3-6 months. Apply now 👇

There is a company called Bexorg and what it does is astonishing. The company takes dead human brains and revives them. Yes . . . really. This science could be the key to developing drugs for all sorts of conditions including Alzheimer’s, Parkinson’s, dementia and ALS. We've published a mini-doc and a detailed story on Bexorg's work right here - corememory.com/p/theyve-reviv… I promise that it will be the craziest thing you see and/or read today.

@sethbannon I got into bio because of GATTACA and it's now happening!

A shocking number of synthetic biologists got into it because of jurassic park.

You may have noticed some "holy $%@#" tweets on fly brain emulation. So is this a game-changer or a nothing-burger? Read on to find out...

Meet the 14 exceptional scientists and innovators who will define the next decade of breakthrough innovation as the @coeff_giving x Big if True Science Accelerator Americas cohort. Here's what they're building: 🧵 1/15

Excited to announce The Eigenprize. With @thewildstevenp, @menemazarakis, @markkhrapko, we’re launching the easiest source of capital for talented people. 10 minute application for $100K. No equity or expectations. Show us what you built or discovered! eigen.build

.@E11BIO is proud to be supported by @jamesfickel and Amaranth Foundation, among other amazing organizations building the future of neurotech, longevity, and safer AI!

Finding new medicines is getting more and more expensive, and AI won't help much unless we can generate physiological data at scale. In our new preprint, @GordianBio extends the progress of the functional genomics community to run pooled in vivo screens at scale, in a way that answers questions about physiology and therapeutic potential. We show screens in mice and horses, fibrotic and degenerative disease, with a framework for physiological predictions validated in human ex vivo tissues. Very proud of @v_sontake, @vkartha88, Neety and the rest of the team. Tweetorial follows:

creating a groupchat for biotechies, humans-only, independent projects encouraged drop your fav bio-meme below to get added

Can we use biomarkers to quantify pain? @alexsaraki is working to find out.

@SexyLikeMeiosis It was indeed painful

@junaxup omg such a whimsical name for something I assume was... quite painful 😬

TIL about the existence of blebbisomes (large extracellular vesicles that contain everything but a nucleus) and they are named this because they, in the technical parlance, "bleb around" it's so WHIMSICAL i'm so happy bleb bleb bleb

Heuristics for lab robotics, and where its future may go (8.4k words, 38 minutes reading time) owlposting.com/p/heuristics-f… this is the longest article i have ever written. in it, i discuss the three ideologies of lab robotics progress, why they may all converge on the same business model, whether any of it will be actually helpful for the problems that plague drug discovery the most, and more this article involved discussions with sixteen people over the course of three weeks, and i am very grateful to them for answering the many questions i had about a field that i had long considered alien finally: this is a complicated field that is really still being birthed, so please let me know if i got anything wrong

Is this microscopic worm sentient? It’s a tough question! Increasingly, however, neuroscience is providing insights into the physical correlates of consciousness at the scale of individual neurons, and we should be excited about what it has to offer. A thread and and article.

🧵 Elon: “Longevity is an extremely solvable problem” At Vitalist Bay (May 14 - May 17), we’re solving it! 1K+ pioneers, 100+ speakers, 50+ workshops, 40+ activities, 5 critical health tests Join us to spark dozens of SpaceXs for longevity!

Light microscopy connectomics named a technology to watch in 2026 by @Nature! With shoutout to @E11BIO. nature.com/articles/d4158…

Great report on the state of brain emulation

How could tiny breakthroughs in aging science change U.S. GDP and population growth? What’s the economic value of making 41 the new 40, or 65 the new 60? How many lives could we create or save if we could slow reproductive or brain aging by just 1 year? What would billions of healthier hours be worth to the economy, if we assume no change in the age of retirement? I spent the last two years obsessing over the design, research, and execution of this project. The result is a book upcoming with Harvard University Press, a preprint, and—maybe your favorite part—an interactive simulation tool that lets you input your own timelines and assumptions for specific breakthroughs in aging bio, then see the ROI in terms of US population & GDP growth. From @RickEcon and Jason DeBacker—the economists who co-developed the open-source, macro model that made this project possible—to extensive comments by @tylercowen, @sapinker, Richard Freeman, @NDHendrix, @ebudish, @elidourado, @geochurch, @jasoncrawford as well as interviews with 102 scientists (!) and countless iterations with award-winning designer Giorgia Lupi and the @pentagram team, we built something we hope will be a benchmark for how scientists, economists, designers, philosophers, entrepreneurs and storytellers can come together to paint, fund, and build different flourishing futures for our species. I couldn’t be more excited to share this. It’s the start of an open and evolving project—the labor and product of love, obsession, and unrelenting care. I hope you have fun playing with our simulation tool — and if you do, please share!

@ArtirKel @EvEBiotech Check out verisimlife.com/solutions/effi…

FRO idea: @EvEBiotech but for PK: take a ton of molecules and many human volunteers (and animal no volunteers), collect PK data, build a SMILES to real life PK predictor, save tons of time for biotechs.