Matthew Wipperman

Congrats @davidjglassMD!! This was excellent and I really enjoyed it.

Below is a non-serious statement, and an example as to why the Aging field is at risk of being pulled into a vat of snake oil.

Nature research paper: Diet outperforms microbial transplant to drive microbiome recovery in mice. go.nature.com/3YXbf0i

NEW WHOOP RESEARCH ON EXERCISE & SLEEP I am proud to share that @WHOOP research has just been published in @Nature. Our study analyzed 4.3 million nights of sleep across ~15k WHOOP members to answer a simple but important question: does working out at night hurt your sleep?

How gut microbiome research needs to move forward. Going multi-omics, getting to causality, rigorous clinical studies cell.com/cell/fulltext/…

My 2022 "Uniquely Stupid" article is back on @TheAtlantic's most popular list. It's about how morally homogeneous institutions became "structurally stupid" after social media made it easy for the extremes to attack and silence moderates and dissenters: theatlantic.com/magazine/archi…

@davidjglassMD Let’s talk!!

Can we stop using the 6 minute walk test, and the stair climb test? These very short, motivation-based exercises have killed more muscle drugs than I care to mention. How about using modern 24-hour monitoring devices -like your smart watch to get more objective measurements?

This study from @ScrippsRTI examined wearable data like step count, resting heart rate, & sleep to track changes in people with + without #LongCovid over a year. Those with Long #Covid_19 had significantly different resting heart rate & activity levels. They were also more likely to be women, younger, unvaccinated, & report more acute-phase symptoms. nature.com/articles/s4174…

Wearables let us study how #sleep differs between or within people. With 5 million nights of data, @varunknath et al. found that changes in sleep over time are associated with acute & chronic conditions inc. COVID-19, fever, flu, #diabetes & sleep apnea. nature.com/articles/s4174…

Predicting Parkinson's disease up to 7 years before symptom onset with a panel of 8 protein biomarkers @NatureComms nature.com/articles/s4146… (adds/orthogonal to the retina image that can do this well)

Walk this way elifesciences.org/digests/86132/…

This perspective discusses how a convergence of progress by patients, advocates, developers, regulators & other stakeholders is driving real progress towards enabling more digital evidence tools to be used for decision making in #drugdevelopment. nature.com/articles/s4174…

New Article in @eLife - Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning @junkRNA @Regeneron @MoticonScience @ISPGR @esmac2019 #digitalbiomarkers #digitalhealth #gait #walking #mobility elifesciences.org/articles/86132

Open Access: Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy. First and corresponding author: Matthew F. Wipperman; corresponding authors: Jennifer Hamilton and Meagan P. O'Brien Read the article here: doi.org/10.1111/all.16… This study aimed to understand the pathobiology of allergic rhinitis (AR) by analysing transcriptome data from nasal brushing samples of individuals with and without AR, and those undergoing different treatments. The study evaluated how treatments, including #dupilumab, subcutaneous immunotherapy (SCIT), and a combination of both, versus placebo, influenced AR and allergen challenge specific gene signatures in nasal tissue. Results showed that both dupilumab and SCIT+dupilumab significantly repressed the AR disease signature, and all three treatments repressed the nasal allergen challenge (NAC) gene signature. #Allergy_journal @junkRNA Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinus…

Your weekend read editorial: Discussing the importance of shifting the focus towards clinically relevant outcomes, when adopting #ArtificialIntelligence tools, the ecosystem required for AI to succeed in health, & the human aspect of #healthcare. nature.com/articles/s4174…

How many genes are in the human genome? (The third in an irregular series of threads about #Bioinformatics.) Let’s start by restricting “gene” to mean “protein-coding gene.” For the moment, this number appears to be just under 20,000, far lower than it used to be 1/11

This also makes a great case for preprinting -- a high-impact paper will get a lot of eyes on it before it gets published in a fancy weekly magazine.

It's a shame that this is drawing attention away from the incredible accomplishments of the @AllofUsResearch program in building a massive, diverse cohort that will fuel decades of important research.

New paper from @Regeneron about #allergy #biomarkers in @AllergyEaaci! Differential modulation of allergic rhinitis nasal transcriptome by #dupilumab and allergy immunotherapy. #immunology #sciencetomedicine doi.org/10.1111/all.16…

Commensal bacteria in the gut #microbiome display surprising resilience to #antibiotics, evolve resistance mutations, and reestablish a healthy biome after treatment, shows a 20-month long study of patients with #tuberculosis. @BucciVanni @MichaelGlickma1 scim.ag/5A0