Jure Leskovec

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Relational Foundation Models face a scaling problem: diverse training datasets are rarely public due to privacy constraints 🔒. 🚀 We are excited to introduce "PluRel": a framework that synthesizes diverse multi-table relational databases from scratch, unlocking scaling laws for RFMs. 🧵 Kudos to the amazing collaborators at @StanfordAILab @Kumo_ai_team , and @SAP : @_rishabhranjan_ @VHudovernik @vijaypradwi @johanneshoffart @guestrin @jure

Today we’re launching Phylo, a research lab studying agentic biology, backed by a $13.5M seed round co-led by @a16z and @MenloVentures / Anthology Fund @AnthropicAI. We’re also introducing a research preview of Biomni Lab, the first Integrated Biology Environment (IBE), where we’re imagining a new way biologists work. Biomni Lab uses agents to orchestrate hundreds of biological databases, software tools, molecular AI models, expert workflows, and even external research services in one workspace, supporting research end-to-end from question to experiment to result. Agents handle the mechanics, while you define the question, then review, steer, and decide. Scientists end up spending more time on science: asking questions, understanding mechanisms, and eliminating diseases. Phylo (@phylo_bio) is a spin-out of @ProjectBiomni, where we will maintain the open-source community and push open-science research. I’m grateful to continue building with my co-founders @YuanhaoQ @jure @lecong and the dream founding team @serena2z @TianweiShe @huangzixin20151 @gm2123 @margaretwhua @malayhgandhi. We’re also fortunate to be advised by leading scientists @zhangf, Carolyn Bertozzi, and @fabian_theis, and supported by an amazing group of investors including @JorgeCondeBio @zakdoric Matt Kraning @ZettaVentures @dreidco @conviction @saranormous @svangel @valkyrie_vc and others. Biomni Lab is available for free today: biomni.phylo.bio Learn more in our launch post: phylo.bio/blog/company-f… We are also hosting launch events - join us at South San Francisco: luma.com/n8k8qb0n Virtual: luma.com/l5ryjaij We’re also hiring! phylo.bio/careers

LLM memory is considered one of the hardest problems in AI. All we have today are endless hacks and workarounds. But the root solution has always been right in front of us. Next-token prediction is already an effective compressor. We don’t need a radical new architecture. The missing piece is to continue training the model at test-time, using context as training data. Our full release of End-to-End Test-Time Training (TTT-E2E) with @NVIDIAAI, @AsteraInstitute, and @StanfordAILab is now available. Blog: nvda.ws/4syfyMN Arxiv: arxiv.org/abs/2512.23675 This has been over a year in the making with @arnuvtandon and an incredible team.

SAIL is still accepting applications for the SAIL Postdoctoral Fellowships! This is an opportunity to work with our wonderful professors and community. Applications received by the end of December 15 will receive full consideration: ai.stanford.edu/postdoctoralfe…

Biology emerges from interactions at different physical scales, from molecular to cellular to multicellular layers. Introducing PULSAR🌌, a multi-scale and multicellular foundation learns how genes impact cellular states and how groups of cells coordinate to collectively define health and disease. @jure @YanayRosen @StanfordAILab @AllenInstitute 🧵1/n: