biokros

@vgm2121 @hubermanlab Eli Lilly

@hubermanlab What companies are doing it the best?

I predict peptides will change everything re public health discourse for health & disease. B/c they’re closer to medications (in many cases actual medications!) than supplements but they entered the picture in supplement-like fashion. HRT went the other direction. Get educated.

@RickLundberg @hubermanlab Terrible half life, too- you need non- natural AA analogues to create an actual drug.

@hubermanlab Do you just mean injected peptides? Cuz most peptides are degraded in the gut when delivered orally...and then they're no better than placebo (like a lot of supplements)

@hubermanlab Good luck formulating- great potency, but terrible drug properties.

@homegymcoop 300-500x the cost

I want to start a gym equipment company that makes everything out of tungsten instead of steel or cast iron. This way you could truly justify every home gym purchase as an “investment.”

@YourDocGoku @davidasinclair This is the same guy that sold the drug to GSK and got sued for it

David Sinclair's lab is using AI to build a pill that reverses aging for $100. Right now, their gene therapy costs roughly $10 million to manufacture. It requires a direct injection into the target organ. That's not going to work for 8 billion people. So Sinclair's team made a breakthrough. They found that the three age-reversal genes aren't the only path to resetting cells. They discovered CHEMICALS that do the same thing. In mice, they can now give an animal a liquid — not genes, not injections, a drink — and rejuvenate tissues in 4 weeks. Sinclair says it's now normal for his students to casually report: "We just rejuvenated the ear. We just rejuvenated the skin. We just cured ALS (motorneuron disease) in these animals." He calls his lab "Willy Wonka's chocolate factory" because the discoveries blow him away every week. But he wants one molecule that does everything. So they used AI to screen 8 BILLION candidates. They're now down to three molecules that work. And they're using AI to try to combine all three into one. The gene therapy could cost over $100,000 per treatment. Sinclair's goal: "What if it could be $100 instead? That's what I'm working for. I want to democratize this technology so anyone even in Kenya can take these medicines." They should know within a year or two if the molecules work in mice. The gene therapy is the proof of concept. The pill is the endgame. — @davidasinclair

@HankFrank You should call Animal Control

This morning a dog sent me to the ground mid-workout. The owner’s reaction was somehow worse than the fall. I love dogs. This isn’t about the dog. Rep 11 of 16x800m on a track. Running 5:20 pace. An off leash Doberman comes out of nowhere and levels me. Both knees scraped. Both hands scraped. Hip badly bruised. The owner kept walking. Didn’t even turn around. I got up, caught up to her, and asked her to please leash her dog or leave the track. She called me entitled. I moved to the road. Finished every remaining rep. Added one more for the one she cost me. She tried to end my workout. She gave me an extra rep instead.

@ShangguanJiewen Tiananmen Square was the ultimate sign of peace

🇨🇳China is the ONLY modern world power to ascend to its status, in peace. Spain was an empire. France was an empire. The UK was an empire. The USA is an empire. China is a global trading partner. We should learn from China's example. Facts matter.✔️

@AlpacaAurelius So it’s correlated with sitting all day

fluorescent lights double the risk of malignant melanoma maybe the real lights we need to be worried about are fluorescent lights not the sun...

@caallmeeden @Jonny_Dutch Darren Sproles had a great career

@Jonny_Dutch he has that west african build, but he simply isn't tall enough. google says he's 5’8, which is just too small for football or hoops.

What’s his actual story? there’s no way he’s this athletic/talented by chance

@Kekius_Sage It takes $1-4 B to discovery and develop one drug. Call me highly skeptical that OpenAI will have meaningful impact.

🚨 BREAKING: Sam Altman says OpenAI will spend at least $1B next year to help AI discover cures for diseases, including cancer.

@Brady_H Sleep any better?

A few nutrition changes/experiments I’m running lately: • Eat 3/4 of the day’s calories before dinner Target right now is 3,500–3,800/day, so ~2,400–2,800 pre-dinner. Places more calories around am workout and doesn’t leave me “compensating” at night or going to bed too full. • Swap some protein for carbs Naturally I’ll eat way more than 1g/lb body weight, so I’m trying to cut protein intake by 40–70 grams per day by replacing a serving of meat/eggs at a meal with a carb/starch (I’ll still eat >1 g/lb with this approach).

@LuizaJarovsky Biology is probably the last thing ai will be able to model/predict

Everybody wants AI to help cure cancer. Why isn't every AI company obsessively focused on that?

@Nicolascole77 What about PhD programs? Ai won’t be conducting all the science.

I've been saying this for years. My goal is to teach my kids how to be financially self-sufficient by the time they're 18. If they want to use their money to go to college "for the experience," that's their decision. 0% chance legacy education keeps up w/ technology.

@CoachDanGo How old are they?

There is a 99% chance my kids will not go to college. If they want to go, then cool. But I don't see the point in going to college or any form of traditional schooling, given where the world is headed.

What did he do to his jumper bro

@davidasinclair When did you give up red wine?

For $1M, I wouldn’t START drinking again

@LoudOutside The kid deserves probation

Colorado CEO sentenced to 30 months probation after grabbing teen by the neck and slamming him to the floor after he threw water on his wife at In-N-Out burger

@mhp_guy Hopefully your son enjoyed the fish tank and animals. That’s one positive take away (hopefully).

I walked into Cabela’s tonight for the first time in 5 years. I notice the sign also says Bass Pro. Huh. Whatever. I walk in and they say “welcome to outdoor world!” Uh, ok. Three names? Wasn’t the merger a decade ago? There are more employees than customers. Total crickets. 77,000 empty square feet. The dude at the entry gives me the hard sell to join their rewards program, while the outside air is still on my neck. I’m just here for a knife dude. I won’t be back for another 5 years. I wrangle from his grasp. As we go to leave they push me to join their rewards program yet again. What a trainwreck. This is what poor management looks like.

@joshuasforrest @Levels @TokuHealth “Zero meds”. Nattikinase is the med. Whether supplements or pharmaceuticals, they are all molecules. Supplements are not well regulated for substance or purity.

Nattokinase is catching on. My results using it with @Levels Heart Health Program: ApoB ⬇️ 33% to 66 mg/dL Zero meds. Labs + logging w/ Levels and high dose nattokinase from @TokuHealth.

@DeryaTR_ Not a chance

Yes. AGI has been achieved. We are now working on its levels to reach superintelligence (ASI).