KB Choi

639 posts

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KB Choi

KB Choi

@kwangbom

Scientist in Computational Genomics, developing novel computational methods for high-throughput omics data. All views are my own. https://t.co/weMgLuJLvj

San Carlos, CA Katılım Nisan 2010
484 Takip Edilen493 Takipçiler
KB Choi retweetledi
Rafael Irizarry
Rafael Irizarry@rafalab·
This UMAP plot was generated from data simulated without inherent clusters, meaning the observed clusters are artifacts. It highlights how default Seurat clustering and UMAP settings can sometimes produce misleading patterns in data visualization.
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Jeffrey Millman
Jeffrey Millman@JeffreyRMillman·
Excited to share that I’ve been promoted to Full Professor! Grateful for the support from my colleagues, students, and the entire academic community. Looking forward to continuing our journey of discovery and innovation together in #diabetes research!
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BBSP @ UNC
BBSP @ UNC@UNCBBSP·
Prof. @mikelove of @UNC_GMB and @uncbiostat is receiving our next mentoring shout-out. Dr. Love was nominated for being an advocate for his trainees.
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𝕐
𝕐@nomad421·
Oarfish: Enhanced probabilistic modeling leads to improved accuracy in long read transcriptome quantification biorxiv.org/content/10.110…
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Jay Shendure
Jay Shendure@JShendure·
Our latest out today in @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: rdcu.be/dyDAg
Jay Shendure@JShendure

Excited to share our lab's latest preprint, led by @CXchengxiangQIU, @bethkarenmartin & Ian Welsh of @jacksonlab. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n

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Avi Srivastava
Avi Srivastava@k3yavi·
After an incredible 3.5 years, today marks the conclusion of my journey at @nygenome. It's very difficult to bid farewell to my exceptional colleagues at Satija Lab. However, I am wholeheartedly excited to embrace the next phase of my career journey @TheWistar.
Avi Srivastava tweet media
Avi Srivastava@k3yavi

Last day at Computer Science Building. I never realized how much one can get attached to the workplace. All your Ph.D. career you think when are you gonna graduate but when it's time you don't want to. Hopefully the plan to balance the emotions with Christmas is gonna work .

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KB Choi
KB Choi@kwangbom·
It might be interesting to see erosion of XCI/XCR in iPSCs derived from genotyped donors using this new method.
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Luca Pinello
Luca Pinello@lucapinello·
1/6 A little thread to celebrate this milestone! Our SIMBA manuscript has finally seen the light of day, after a journey of more than 2 years. It's been an intense ride, but we're thrilled with the result.
Nature Methods@naturemethods

SIMBA learns a co-embedding space of single cells and multiple features such as genes, chromatin accessible regions, and transcription factor binding sequences, boosting performance of various analyses of cellular diversity and regulation. nature.com/articles/s4159…

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Ewan Birney
Ewan Birney@ewanbirney·
It was a tour de force just generating a draft human pan-genome @HumanPangenome, but some suspected and some utterly bizarre things about the human genome have been revealed using these 47 different human reference quality genomes.
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KB Choi
KB Choi@kwangbom·
@Cnspracklen @vishalsarsani Small world. Vishal worked with us at the Jackson Lab before he moved on to his pursuit on doctoral degree.
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Adam Phillippy
Adam Phillippy@aphillippy·
My favorite T2T/Pangenome discovery so far: a multi-megabase inverted segmental duplication on the short arm of chr14 that explains the mechanism of Robertsonian translocations. Great writeup by @ScienceStowers "Answering a 50-year-old mystery" stowers.org/news/investiga…
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Michael Love
Michael Love@mikelove·
This is a really well done python reimplementation of DESeq2 and apeglm, I’ve checked the code closely. Nice work @BorisMuzc @Kramarek et al
Owkin@OwkinScience

Meet PyDESeq2 – a Python-based software package for #RNAseq differential expression analysis based on DESeq2. Owkin is open-sourcing PyDESeq2 to support the growing community of bioinformaticians adopting Python for their data analysis workflows. Check out PyDESeq2 on GitHub at github.com/owkin/PyDESeq2 Read more at owkin.com/en/publication… #bioinformatics #python

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biohub
biohub@biohub·
We’re excited to announce 20 new Data Insights grantees addressing challenges in #SingleCell biology by: 🔹Integrating data sets to understand cell functions that regulate health + disease 🔹Applying #ML methods to the analysis of complex data sets czi.co/3K1mtJ4
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