Lisa Kinch

What would it look like to see all ~13,000 proteins inside a single human cell at once? We share ProtiCelli — a generative model that makes this possible. Besides benchmarking, we demonstrate utility in many tasks. Preprint: bit.ly/3NY175q A thread 🧵👇

To be out soon: nucleotides at receiving end of counter-invader conflicts.

We added *active* AlphaFold2 models of all 437 human catalytic kinases to Kincore-available on every page (PDB, Gene, Family, etc.). All PDB/AF2 structures now have "Activity label" based on XDFG, saltbridge & substrate-capable activation loop positions. dunbrack.fccc.edu/kincore.

1/3 Our pan-cancer structurome paper is out 🤩 @SciReports nature.com/articles/s4159… We evaluated the pan-cancer structurome, domains from over and under expressed proteins in 21 cancer types @kennethschen #Bioinformatics #computationalbiology

The Orth Lab thanks ya’ll for this wonderful comment!!!! A nonstop thrill ride from genes to the assembly of the T3SS injectisome | Nature Communications nature.com/articles/s4146…

Fav quote “hypocrisy at its highest order” -John Stewart

Our article on how Vibrio utilizes a long hypothesized assembly paradigm #transertion to assemble its T3SS is finally out @naturecomms Grateful to our team at the Orth lab @orthkim @UTSWMolBiol for helping put this together nature.com/articles/s4146…

A tour de force in RNA biochemistry by @BBS_McMasterU PhD student @NathanBullen4 ! Thank you for teaching me all about the wonderful world of bacterial RNAs and how they are subverted by this potent antibacterial toxin. cell.com/molecular-cell…

I am happy to announce 1-2 PhD positions in deep learning on protein-protein interactions, in Stockholm in a great scientific environment. Please help me spread the word. su.se/english/about-…

Today in partnership with @emblebi, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: dpmd.ai/AF-22-TW 1/

UT Southwestern researchers use AI to detect new family of genes in gut bacteria : Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/artic…

There are 296 new entries in the PDB this week, including the 1st PDB structure of @uniprot ID O57880 - transcriptional regulator PH0140 from P. horikoshii OT3. The complex is shown here with the #AlphaFoldDB prediction overlaid. View all new entries: pdbe.org/latest

@LindorffLarsen How about this one? Gene LOC112267897

In today's episode of amazing proteins, meet mucin

@DKThomp Three tenors Hyde park! Princess Diana in attendance. Free concert for all in the rain. Will never forget.

I recently had a fun debate about this, so let's open it up: What's the most ICONIC vocal performance in the history of recorded music?

An exciting OA paper came out yesterday! ColabFold is a free platform for protein folding, providing rapid protein structure and complex predictions using AlphaFold2 or RoseTTAFold. @milot_mirdita @konstinx @Ag_smith @huhlim @sokrypton @thesteinegger nature.com/articles/s4159…

Happy to share our discovery of co-component signal transduction systems. Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pn…

Fantastic invited speaker @janetiwasa for our @biophysics_utsw retreat. Inspiring work!

Congrats Meg! Couldn’t have asked for a better PhD advisor.

Excited to watch my advisor @orthkim get inducted into @theNASciences today! Congratulations!

@ClementYChow Flip book style talk! Just my style.

15 min talk...47 slides