Longlong (Lucas) Tu

My 10-year odyssey of motion sickness research.

Understanding of how the #brain regulates #bodyTemperature during #motionSickness may provide unconventional targets for the treatment of #obesity. @DrYongXu1 @longlong_tu et al explain their findings @NatMetabolism @bcmhouston #BCMPostdoc blogs.bcm.edu/2025/04/17/fro…

A personal interest in #motionSickness led them to discovering potential new options for treating #obesity. @DrYongXu1 @longlong_tu explain. @NatMetabolism @bcmhouston #BCMPostdoc #brainCircuit bcm.edu/news/motion-si…

We described a neural mechanism for motion-induced hypothermia which can also be targeted to treat obesity. Congratulations to ⁦@longlong_tu⁩ who started this scientific journey trying to understand his own miserable suffering from motion sickness. nature.com/articles/s4225…

Cellular crosstalk in skeletal muscle? A surprising role for mast cells? Histamine as a signal transducer during exercise? This was an amazing ride during my time @TeamDerave, now published in @Cell_Metabolism (1/11) @ugent_fge, @FWOVlaanderen sciencedirect.com/science/articl…

Improving appetite and weight gain in cancer/chemotherapy... jci.org/articles/view/… Xinxia Zhu & team @OHSUNews tested the melanocortin-4 receptor antagonist TCMCB07 in several preclinical models of chemotherapy.

Our latest paper with @Molofsky_lab is out! tweetorial to follow. Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior | Science science.org/doi/10.1126/sc… @jerika_barron @ Nick Mroz

@xulab_uic @XuPingwen @Jiang_Lab congratulations!!

🎉 Exciting news from our lab! Congratulations to our PI @XuPingwen and our friend and colleague @Jiang_Lab, who have been promoted to Associate Professor with Indefinite Tenure!! Well-deserved recognition for their impactful work! 🏆

Now online! Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing dlvr.it/TGdrYk

Using multiple techniques the authors affirm that Gfral expression is overwhelmingly restricted to the brainstem in healthy mice @MolMetab @cusm_muhc @seeleyrj sciencedirect.com/science/articl…

Does loss of GIPR signaling sensitize GLP-1R+ neurons, enhancing the actions of GLP-1R agonists? New data from @seeleyrj @UMich @MolMetab @UMDiabetes sciencedirect.com/science/articl…

After a strong start, competition for @novonordisk @EliLillyandCo is coming in the #weightloss space, with widespread innovation to bring options for more people @amgen @Roche @AltimmuneInc @StructureTx @Viking_VKTX @pfizer @Boehringer economist.com/business/2024/… @TheEconomist

How our brain and body talk to each other, with control of inflammation and our immune response cell.com/cell/fulltext/… @CellCellPress @rolls_asya @NadineGogolla @PopescuMiranda @SLiberles and colleagues, open-access

@GilesYeo @christs_college @Cambridge_Uni Oh, it's him!! Watched a lot of his interviews on international affairs before.😄😄

Always nice to see my Uncle George Yeo (my dad’s youngest brother), who is a @christs_college @Cambridge_Uni alumnus, and in town for a book launch.

@HongjieLi5 @NIHDirector @bcmgenetics @BCMFromtheLabs @BCMCancerCenter @bcm Congrats!!

Not Nobel, but really glad to receive @NIHDirector’s New Innovator Award. pursue: commonfund.nih.gov/newinnovator/A… #NIHHighRisk @bcmgenetics @BCMFromtheLabs @BCMCancerCenter @bcm

Now online! Divergent sensory pathways of sneezing and coughing dlvr.it/TD69TG

Here suppression of the DMV–vagus–jejunum axis controls intestinal fat absorption by shortening the length of microvilli with therapeutic potential for #weightloss nature.com/articles/s4158…

🚨❗️🚨 New Paper Alert My postdoctoral work now out in @Nature. We find that sensory neurons drive breast cancer metastasis via an activity-dependent paracrine signalling mechanism mediated by substance-P, extracellular ssRNA & TLR7 receptor. (1/11) urldefense.com/v3/__https://w…$ 🧵👇🏾

@liye_tsri @HHMINEWS Congratulations!!

I’m incredibly honored to join @HHMINEWS community. Deeply grateful to my lab, colleagues, collaborators, and mentors. I’m lucky to have you all.

Online Now: Neuroendocrine gut–brain signaling in obesity dlvr.it/T7hVVj #trends #endocrinology #metabolism