Mohammad Kawsar Manik

We are happy to announce that our paper about signaling molecules produced by bacterial TIRs is published in Science today science.org/doi/epdf/10.11…. It was a concerted effort from many groups around the world. Thanks @Piperproduction for rendering for our EM structure of AbTir.

Excited to share our paper on the NLRP3 inflammasome condensate at the MTOC by "precise!" cryo-electron tomography (cryo-ET), in collaboration with Jue (phyllis) Wang@Phyllis23382012in the labs of Grant Jensen (BYU) and Pete Dahlberg (Stanford)! science.org/doi/10.1126/sc…

@Kobe_Lab_ Congratulation Natsumi and the team.

Check out our recent preprint on the structure of a non C-JID TNL resistosome from flax. We are very proud of the persistence of Natsumi who got this long running project over the line and a congratulations to all involved. Check it out... doi.org/10.64898/2026.…

🤣🤣🤣 Days of the week matters for publication

TIR domain of SARM1 can sense dsDNA and activate its NADase — linking DNA sensing to axon degeneration. I find this a potential paradigm shift in innate immunity. #SARM1 #TIRdomain cell.com/cell/fulltext/…

nature.com/articles/s4156… S. aureus Thoeris sensor ThsB1 recognizes major head protein, recruits cylcase ThsB2, resulting gcADPR signal which stimulates NAD+ degradation by ThsA.

Out Now! Bacterial TIR-based immune systems sense phage capsids to initiate defense bit.ly/4oGhL6l #Microbiology #Bacteria #Immunology

Excited to see our Arabidopsis TIRome paper published in PNAS. Have a read here doi.org/10.1073/pnas.2…. We hope this is the start of tuning TIR domains 😎

Phage DNA modifications evade defense: Phage DNA modification adds arabinose to cytosines via hydroxy linkage(5ara-hC) w/potential double & triple arabinosylation. Arabinosylated phages are protected from DNA-targeting CRISPR-Cas & restriction modification cell.com/cell-host-micr…

This chapter is over. The story? Still being written. Grateful to all.

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…

Plant TIR domains are the coolest TIR domains! Privileged to be a part of this work, that is up on bioRxiv. biorxiv.org/content/10.110… @Kobe_Lab_

Pls RT 🚨I'm looking for someone excited about #proteindesign and #synbio to join my lab @durham_uni and the @CPBM_heddlelab to undertake a PhD using #synthetic knottins as novel #bioinsecticides. If you're interested please get in touch and check out the advert below 👇

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

The NIH announced it will slash billions of dollars of support to universities and research centers. This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.

NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country. Brief explainer for those not in this world: buff.ly/3EtML7D

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats @TanaWein! Thanks Kranzusch lab! tinyurl.com/CA88DD

Just fyi, @deepseek_ai collects your IP, keystroke patterns, device info, etc etc, and stores it in China, where all that data is vulnerable to arbitrary requisition from the 🇨🇳 State. From their own privacy policy:

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! cell.com/cell/fulltext/…

Excited to share our work in @PNASNews . We report the cryoEM structures of both TRIF and TRAM uncovering the molecular basis of TRIF-mediated TLR3 and TLR4 signalling pathways. pnas.org/doi/10.1073/pn…