Matthew Brown, PhD

I’m incredibly grateful for the support from @parkerici with this Early Career Researcher Award and excited for the opportunity to join this amazing network of investigators in the field of cancer immunology. Thank you also for the continued mentorship @BhardwajLab @SinaiImmunol

Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer: Cell Reports Medicine cell.com/cell-reports-m… @BhardwajLab @IcahnMountSinai

Nature research paper: Thymic health and immunotherapy outcomes in patients with cancer go.nature.com/4uzjle1

An innovative approach supercharges the innate immune system to provide a first line of defence against respiratory infections. go.nature.com/4qPVio7

Nature research paper: Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC go.nature.com/3OnBrz1

Nature research paper: Atlas-guided discovery of transcription factors for T cell programming go.nature.com/4afm6b5

Online now: Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo dlvr.it/TQcnRZ

Nature research paper: The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction go.nature.com/457rivW

In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL

Nature research paper: Transient hepatic reconstitution of trophic factors enhances aged immunity go.nature.com/4shOD86

Online Now: IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunity dlvr.it/TPr6sk

Online now: Opposing functions of distinct regulatory T cell subsets in colorectal cancer dlvr.it/TPqp1P

A new study shows that aspirin enhances antimetastatic immunity by decreasing platelet activation, thereby releasing T cells from suppression by thromboxane A2. Learn more in the Clinical Implications of Basic Research article “Understanding How Aspirin Prevents Metastasis” by Ruth E. Langley, MB, BS, PhD, and John Burn, MD, from University College London and @uniofnewcastle: nej.md/4pTzyaw

Now online! Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy dlvr.it/TPNJBs

Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency dlvr.it/TPCFxV

Nature research paper: SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade go.nature.com/4o8ydwh

Nature research paper: In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma go.nature.com/4nLn9o5

In the latest issue! A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma dlvr.it/TNB1ds

Nature research paper: Parent-of-origin effects on complex traits in up to 236,781 individuals go.nature.com/45nrGWl

An exciting summer highlight: @matt_brown04 successfully defended his thesis, “Neoantigen-specific surveillance intercepts precancerous MMR-deficient cells and governs immunotherapy response,” co-mentored by @rsamstein! A major milestone and a proud moment for the lab! 👏🎓

Nature research paper: Whole-genome sequencing of 490,640 UK Biobank participants go.nature.com/45KBcTN