Michael Andregg

151 posts

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Michael Andregg

Michael Andregg

@michaelandregg

ceo of eon | human emulation pbc https://t.co/M7nhgJxMlO prev: optical supercomputers/networking/robotics, high-speed mass production electron microscopy

San Francisco Katılım Mayıs 2009
721 Takip Edilen9.5K Takipçiler
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Michael Andregg
Michael Andregg@michaelandregg·
We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action. A few things I want to say about what this means and where we're going at @eonsys. 🧵
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Michael Andregg
Michael Andregg@michaelandregg·
The flywire/janelia brain was preserved with aldehyde fixation. @aureliasong just published how she scaled the same approach to whole large mammal brains: every synapse (randomly sampled, and verified by BPF), connectomically traceable. Uploading is still years out. But preservation is step one, check out their article
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Michael Andregg
Michael Andregg@michaelandregg·
We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action. A few things I want to say about what this means and where we're going at @eonsys. 🧵
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Aran Nayebi
Aran Nayebi@aran_nayebi·
Does anyone know how this virtual fly moves *without* RL, given that the actual motor neurons weren't traced out (because the body wasn't scanned)? @Leokoz8 @michaelandregg @oh_that_hat @eonsys @alexwg @Philip_Shiu @AdamMarblestone
Hattie Zhou@oh_that_hat

There's a fruit fly walking around right now that was never born. @eonsys just released a video where they took a real fly's connectome — the wiring diagram of its brain — and simulated it. Dropped it into a virtual body. It started walking. Grooming. Feeding. Doing what flies do. Nobody taught it to walk. No training data, no gradient descent toward fly-like behavior. This is the opposite of how AI works. They rebuilt the mind from the inside, neuron by neuron, and behavior just... emerged. It's the first time a biological organism has been recreated not by modeling what it does, but by modeling what it is. A human brain is 6 OOM more neurons. That's a scaling problem, something we've gotten very good at solving. So what happens when we have a working copy of the human mind?

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Michael Andregg
Michael Andregg@michaelandregg·
@michalj love your work! hopefully this gives a little more info. had no idea this was going to blow up
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Michael Andregg
Michael Andregg@michaelandregg·
@kanzure @alexwg We haven't explored this but to give a sense of how robust brains are, in Flywire brain only 40% of the synapses traceable to a cell body. So 60% of the synapses visible in the electron micrographs were not traceable to cell bodies. So we did not include them in the simulation.
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Bryan Bishop
Bryan Bishop@kanzure·
@alexwg How many neurons or synapses can you delete before the behavior doesn't match?
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Michael Andregg
Michael Andregg@michaelandregg·
@gpl_94 you made this possible. Grateful for your vision and support from the beginning! it takes a lot of conviction and independence to take a chance on something so far out of the overton window as uploading🚀🔮
george@gpl_94

Grateful to have been the first investor in @eonsys back in 2023. What @michaelandregg and team have achieved on a modest budget is incredible. Meanwhile hundreds of billions are flowing into AI compute while connectomics—the actual blueprint of intelligence—remains underfunded. The Overton window is shifting.

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Owen Lewis
Owen Lewis@is_OwenLewis·
@michaelandregg @FlyWireNews @Philip_Shiu This is going to change everything if it scales up. If whole brain and body simulations work with mice, it'll probably work with humans. So the biggest step is really from flies to mice. Question, when do you plan to add body scans and behavior plasticity so it can learn?
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Michael Andregg
Michael Andregg@michaelandregg·
@agapekeleta @FlyWireNews @Philip_Shiu Can't share too much right now but it really depends on funding. I think it's a massive microscope scanning challenge + image processing (stitching, tracing, segmentation, proofreading) but a known engineering problem. The biggest uncertainty is the neuron modeling part.
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Agape Keleta
Agape Keleta@agapekeleta·
@michaelandregg @FlyWireNews @Philip_Shiu Awesome! What are your predictions for the timeline of modeling the full human brain connectome? How much money would need to be spent on this project, how feasible would it be, and when will it happen?
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Michael Andregg
Michael Andregg@michaelandregg·
Brain emulation allows humans to flourish in a world with superintelligence. We're a small team in San Francisco working on what I believe is the most important technology of this century. Reach out if you want to help build this! 🚀 eon.systems
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