Michael Xiao

Happy to share our new preprint! We identify a novel cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate via PASK, a metabolic sensory kinase enriched in self-renewing stem cells. biorxiv.org/content/10.110…

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…

Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @Cell_Metabolism @RockefellerUniv cell.com/cell-metabolis…

I am thrilled to share that our recent study on the development of a metabolic gene function discovery platform is now online on Nature Genetics. nature.com/articles/s4158….

Congrats @beccatimson for generating a mouse model to study GSH limitation in vivo. @RockefellerUniv sciencedirect.com/science/articl…

How does mitochondria sense and control their glutathione levels? Our new work @ScienceMagazine by a fantastic student @YuyangLiu1996 describing a redox metabolite sensing mechanism for mitochondria. @RockefellerUniv @TheMarkFdn science.org/doi/10.1126/sc…

(Thrilled to have my first Twitter Thrill) Thrilled to share my first paper published today ⁦@ScienceMagazine⁩. How does a cell monitor metabolic homeostasis across so many subcompartments? We tried to offer a hint by looking at GSH in mitochondria. science.org/doi/10.1126/sc…

@RyanLab_MBU @KikaniLab @eLife Thank you @RyanLab_MBU!!

@michaeljxiao @KikaniLab @eLife Congratulations Michael!

Excited to share the latest preprint from @KikaniLab! We unravel the biochemical regulation of PASK, a metabolic sensory kinase that we previously found to be necessary for establishing stem cell fate biorxiv.org/content/10.110… (Previous paper: @eLife elifesciences.org/articles/81717…)

Choline is an essential metabolite with multiple metabolic fates once inside the cell. Despite this, it’s unknown how most mammalian cells uptake choline. Excited to share my work from the @KivancBirsoy lab implicating FLVCR1 in choline transport! biorxiv.org/content/10.110…

Congrats @GokhanUnlu_ ! Our new work describing a way to identify metabolic limitations under stress conditions @RockefellerUniv @DamonRunyon @psscra authors.elsevier.com/a/1fFpK3vVUPK8…

@krbyleo @TheBethesdaLabs @MarkKnepper6 Congrats!!

Happy to share my IRTA gap year work in which we propose a novel signaling network using time course data and other large-scale “omic” sources! @TheBethesdaLabs @MarkKnepper6 biosignaling.biomedcentral.com/articles/10.11…

HUGELY important work (and I can only imagine a herculean effort 😭) to generate H3K27 mutants at every allele in mammalian cells nature.com/articles/s4158…

@DylanRy1937 Thanks @DylanRy1937!! Stay tuned!

@michaeljxiao Congratulations Michael! Great to see the work out and looking forward to reading. Give us a tweetorial if ye get the chance 😀

Happy to share our new preprint! We identify a novel cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate via PASK, a metabolic sensory kinase enriched in self-renewing stem cells. biorxiv.org/content/10.110…

A very exciting piece of work from @michaeljxiao on glutamine metabolism in determining stem cell fate!

Amazing work from @RutterLab alumni Chintan Kikani's lab, led by another lab alumni @michaeljxiao! @HHMINEWS @UKarts_sciences @universityofky

Special thanks to Dr. Chintan Kikani @universityofky, who has mentored me tirelessly over the years, the Kikani Lab members, and our collaborators @UKY_Sunlab, Gentry Lab, and @BanaszynskiLab! Also thanks to @RutterLab!

@Azim_Dharani @ReisnerLab @SamCobb_Chem Congrats!!! Well deserved

Glad to have contributed to this project during my MPhil in the @ReisnerLab alongside @SamCobb_Chem! With this work, we show how to modify the local environment for improved enzyme-assisted fuel production. nature.com/articles/s4155…

@Eric_Y_Wang @aaronmring @connor_rosen Congrats Eric!!

How is the mito-proteome of neural stem cells shaped? In our last work, @GulzarW13675960 found that a rewiring of the mito-proteome by YME1L is key to preserve self-renewal and neurogenesis! Thanks to @CECAD_ @MPIAGE @CRC_1218 @crc1451 @ERC_Research cell.com/cell-reports/f…