murray gilman
5.8K posts
murray gilman
@murraygilman
pulmonary physician retired 2015, McGill Medicine grad 1975, Johns Hopkins pulmonary 1980
Atlanta, GA Katılım Eylül 2014
509 Takip Edilen497 Takipçiler
@tlitb @mattwridley Version 1 of 7-case definition (January 15-18)
Epidemiological history:"had direct/indirect exposure to markets (especially wet markets) in Wuhan within two weeks before illness onset"
Version 2 (January 18-January 22) - no mention of the wet markets
From Lancet PH 2020 Tsang
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In the Rasmussen et al commentary on @mattwridley talk, noticed that Kristian Andersen asserts absolute certainty the Huanan case definition literally just lasted 3 days between Jan 15-18!?
What does he think was the criteria before that date?
He's absolutely wrong, see quoted
The Leopard In The Basement Is A Sensible Name@tlitb
@nicolascgrey @Biorealism @JamieMetzl @Dali_Yang Search for "inclusion-exclusion criteria" in kindle The criteria is especially relevant for Zhongnan hospital across the river because some studies imply cases were found there independent of an explicit directive for market cases only. They were not x.com/tlitb/status/1…
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@thackerpd @DrMakaryFDA "Evidentiary maximalism" should be the goal for any FDA-approved therapeutic. Expanding the 2018 Right to Try Act to include rare disease exemptions should be able to accommodate clinical reality without compromising the overall goal of quality randomized clinical trials
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Robert Goldberg of Center for Medicine in the Public Interest wrote a hit piece in WSJ on @DrMakaryFDA.
Guess who funds Goldberg?
Wall Street Journal Opinion@WSJopinion
One exit won’t cure the FDA’s culture. The agency’s mindset remains: evidentiary maximalism detached from clinical reality, indifference to patient urgency, and hostility to the flexibility Congress intended, writes Robert M. Goldberg on.wsj.com/3Nv51Cn
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@DrJMarine nature.com/articles/s4158…
The Delphi Consensus has determined that “broad restrictions on civil liberties” should be considered “ONLY IN THE EVENT” of (fill in the blanks)
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The most shocking revelation of the covid pandemic for me was the realization that the governor of my state has the power to declare himself a dictator based on any public health pretext, to suspend everyone's natural and Constitutional rights indefinitely, and to coerce anyone to inject anything he thinks beneficial for "public health." Such a state is not compatible with a free republic. It is essential that these unlimited police powers are constrained. I support this resolution and I encourage others to read and consider.
Jeffrey A Tucker@jeffreytucker
They will do it again unless the public speaks out now! CovidJustice.org
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@anish_koka @techjudge Excellent summary.Vinay had the rare combination of unapologetic brashness with a scientific/epidemiological rigor which has been neglected in recent years.The FDA could have used his unique abilities for open debate and public education,but alas,the machine devoured one more ⭐️
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@soncharm @IanSolliec This recent debate at Stanford summarizes perfectly the vast divide concerning the public health response to COVID. Minimal lessons learned by PHE. The same insanity very likely to be replicated for the next “pandemic”
The Researcher@listen_2learn
“Democracy and Disagreement: COVID Policies in Retrospect” Stanford m.youtube.com/watch?v=1osDcy…
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CYA being what it is, accountability and reckoning is almost surely too much to hope for.
What bothers me more than this is the suspicion that they’d do it all over again.
‘Public Health’ gurus and Lockdown fans may have been forced by political winds into a defensive stance temporarily, but I get no sense that deep down they think anything done was just *wrong*.
If anything, I think they mostly think it all should’ve been done *harder*.
This power needs to be explicitly removed from consideration, and ‘Public Health’ diktat powers tightly constrained in general, for me to be satisfied. It’d be totally worth some kind of amnesty to get there.
Hans Mahncke@HansMahncke
Covid was one of the greatest abuses ever inflicted on humanity, and there will be no historical closure and no healing until there is genuine accountability and a full reckoning. On the vaccines, regardless of what anyone thinks about their effectiveness or their risks, it is beyond dispute that Anthony Fauci and his pharmaceutical partners were eager to rush these products to market without the normal years long trials. They had wanted to deploy mRNA technology for decades but could not effectively deliver it into the human body until 2018, when a new delivery method became available. From that moment on, they were itching for a chance to deploy it. Covid became that opportunity. But the vaccines are only one part of what demands accountability. The origin of the virus itself, which also leads directly back to Fauci, has been deliberately brushed under the carpet rather than confronted honestly. And the same goes for the response. Healthy populations were locked down and millions of lives and livelihoods were destroyed. Immense social and psychological harm was inflicted without any justification. That response too ran through Fauci. Many people may have moved on and seem eager to forget. But these actions do not dissipate with time. There is an unpaid debt of responsibility, and it will remain until the truth is faced and accountability follows.
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@DrJMarine @DRsLoungePod @NIHDirector_Jay @NIH This debate at Stanford should be a model for discussion around the country.
The contrast in opinions between the two speakers was stark and reflects a divide which has barely budged since the COVID catastrophe has receded from our primary focus.
The Researcher@listen_2learn
“Democracy and Disagreement: COVID Policies in Retrospect” Stanford m.youtube.com/watch?v=1osDcy…
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I enjoyed this terrific @DRsLoungePod interview with @NIHDirector_Jay - lots of innovative ideas for improving return on the large US public investment in @NIH . We should welcome reform efforts that will strengthen public support for NIH and biomedical research in the long run. @anish_koka @DrDiGiorgio @sdixitmd
Anish Koka, MD@anish_koka
In this engaging conversation, NIH Director Dr. Jay Bhattacharya discusses the unique perspective his training gave him that influenced his approach to public health, particularly during the COVID-19 pandemic. He reflects on the Great Barrington Declaration, the importance of dissent in science, and the need for reform within the NIH to foster innovation and address the replication crisis in research. Dr. Bhattacharya emphasizes the necessity of a culture shift in science, advocating for transparency and rigorous inquiry into public health issues. Chapters: 00:00 Introduction to Dr. Jay Bhattacharya 03:18 The Influence of Economics on Health Policy 06:23 Unique Perspectives During the COVID-19 Pandemic 10:12 The Role of Authority in Public Health Decisions 13:08 The Great Barrington Declaration and Its Impact 16:27 Challenges to Scientific Consensus 19:08 Leading the NIH: An Economic Perspective 22:33 Addressing the Replication Crisis in Science 36:56 Addressing Scientific Stagnation and Replication Crisis 43:42 Fostering a Culture of Dissent in Science 52:56 Setting Research Priorities for Public Health 59:58 Navigating Vaccine Safety and Public Trust
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@DrJMarine @AppleHelix @Sensible__Med grok.com/share/bGVnYWN5…
Estimates of up to 38% of ILI-like illness remain as unknown etiology even after thorough testing. Probably explains why a universal flu vaccine has not been produced after 40+ years of study
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It is completely opposite of "Evidence-based Medicine" for @Sensible__Med to reflexively retweet Aaron Siri without actually looking at the EVIDENCE.
$MRNA did run a 3000 patient trial comparing a High Dose flu vaccine vs MRNA-1010 and showed that MRNA-1010 was SUPERIOR!
x.com/AppleHelix/sta…
cc @adamcifu @drjohnm @DrJMarine
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@DrJMarine @DavidIAuerbach AI generated informed consent forms based on questions the patient is asking. The pre-printed legal mumbo-jumbo form should be relegated to the dustbin of history. And keep it simple
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@DavidIAuerbach @murraygilman Yes- essential to informed consent and shared decision making.
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A common error I see in evaluating the utility of preventive therapies is failure to appreciate the difference between ARR and RRR and to properly factor in risk of adverse effects. A preventive intervention may have a RRR of100%, but if the rate of the condition in the population is 1/10,000, then the ARR is only 0.01%. Under these conditions, rare ADEs may negate individual and population benefit. Everyone in the treated population is at risk for the ADE, but only 1/10,000 are at risk for the condition being prevented. Adding to the complexity is that ADE rates this low may be difficult or impossible to detect in prospective trials or in retrospective analyses above background rates, unless the ADE is pathognomonic for the intervention. This is a genuine conundrum that is getting lost in the noise.
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@DrJMarine That’s excellent.
For COVID, just using attack rates in an informed consent explanation could have been helpful. As simple as you can get provided by AI
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@murraygilman This is a tool we use primary prevention ICD implantation. It lays out the numbers graphically.
patientdecisionaid.org/icd/
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@jsm2334 Unfortunately, polling data post-RCTs reflected a belief that there was a mortality benefit.
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Sadly, our HHS secretary completely misinterpreted/misrepresented the trial data, which did NOT show the vaccinated with 23% higher all cause death rate than placebo group.
The number of deaths between vaccine and placebo group is only comparable during the blinded period of the trial before crossover, after which placebo participants were offered the vaccine and ~90% took the vaccine.
At that point, the deaths were 15 in vaccine vs. 14 placebo.
The death rates were
15/21,926=0.068% (95% CI 0.038%-0.113%) for vaccine and
14/21,921=0.064% (95% CI 0.035%-0.097%) for placebo, for which the confidence intervals almost completely overlap, showing no significant difference in death rate whatsoever
Given an odd number of total deaths, this as close to equivalent as anything can be.
There is zero evidence, from the randomized trial, or from any observational population level studies of all cause deaths showing vaccinated having anything like 23% increased death rate -- in fact, no population level data sets show increased all cause death rate after vaccination at all, but rather most show a decrease.
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@HansMahncke But we got strongly worded letters 🤡
grassley.senate.gov/imo/media/doc/…
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This is a fantastic scoop that proves what anyone with a functioning brain always knew, which is that the U.S. government knew from day one that Covid was made at the Wuhan lab. The March 2020 slide presentation lays this out in detail. As we have always said, the data was there the whole time. It was never about a lack of evidence, only a lack of honesty.
What is so deeply enraging is that instead of this detailed explanation, which was buried for six years, the public was fed a fraudulent paper from Fauci’s bought-and-paid-for scientists, published at the same time and transparently designed to mislead. When will Fauci finally be held to account?
Gary Ruskin@garyruskin
Defense Intelligence Agency considered lab leak scenario in March 2020, new records show Via @lewiskamb @USRightToKnow usrtk.org/covid-19-origi…
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@murraygilman “Of course, scientists tell us that SARS-CoV-2 did not escape from a jar”
nejm.org/doi/full/10.10…
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Fauci's replacement, Jeff Taubenberger, lying about his lab leak cover-up emails with Daszak, Morens & Fauci
(claimed he was only cc’d but he drafted coverup papers linked below)
Memoli tries to distance themselves and Podcast Jay changes the subject to vax mandates
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@DrJMarine @IanCopeland5 And every vaccine is the same, just like every antibiotic and every anti-hypertensive.
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@IanCopeland5 We also have no lived memories of cholera, yellow fever, typhoid fever, or bubonic plague, but it is not because of vaccines.
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We have no lived memories of such a sight.
Because vaccines have protected you, wether you like it or not...
Neil Stone@DrNeilStone
Remember smallpox? No? Because vaccines work
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@jeffreytucker Yup. “Durably protective vaccines against non-systemic mucosal respiratory viruses with high mortality rates have thus far eluded vaccine development efforts.”
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Did you know that in January 2023, Anthony Fauci signed a paper that essentially admitted that the shot would never have been effective? #free-full-text" target="_blank" rel="nofollow noopener">europepmc.org/article/MED/36…
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@msabouri @DrNeilStone I would be delighted to volunteer for a placebo-controlled trial of the seasonal flu shot.
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It's👏not👏ethical👏to👏do👏placebo👏controlled👏study 👏when 👏there's 👏already 👏an 👏effective 👏vaccine
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