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The SV40 Enhancer Is Extraordinarily Potent The 72bp repeat enhancer in SV40 is one of the strongest viral enhancers known: - Can increase gene expression 100-1000x# - Works in almost all cell types (broad tropism) - Contains GTGGGGGCGGGC - the enhancer core - Multiple repeats amplify the effect Even if SV40 doesn't integrate: - The enhancer DNA can be taken up by cells - It can activate nearby genes in the host genome - This is called "enhancer hijacking" - Can lead to aberrant gene expression If enhancer DNA integrates near an oncogene → cancer Thank you to

NEW - Jeffrey Epstein claimed Bill Gates caught an STD from 'Russian girls' and then asked for antibiotics to secretly give to his then-wife Melinda, according to a 2013 email Epstein sent to himself. Epstein wrote that he was "dismayed beyond comprehension" by Gates's decision to "disregard our friendship developed over the last 6 years." "TO add insult to the injury you them implore me to please delete the emails regarding your std, your request that I provide you antibiotics that you can surreptitiously give to Melinda and the description of your penis." "I suggest I buy you the house that you so had your heart set on and in addition to five years of severance will buy you out of the investment contract we had agree, 30-40 percent of a hundred million dollar partnership." In another email Epstein sent to himself, written as if from the perspective of Gates's then-top advisor Boris Nikolic, Epstein writes: "From helping Bill to get drugs, in order to deal with consequences of sex with russian girls, to facilitating his illicit trysts, with married women, to being asked to provide adderall for bridge tournaments..."