Patrick Kent

@ABsteward …but did they say which group, eh?

🆕💥🟢Trimethoprim–Sulfamethoxazole Susceptibility in Beta-Hemolytic Streptococci in a Canadian Tertiary Center Bactrim showed 99% in vitro activity against beta-hemolytic streptococci 98% to levofloxacin, 74% to tetracycline, and 72% to clindamycin sciencedirect.com/science/articl…

@DrOBrienMD @drterrysimpson Yeah more February intern vibes than anything. And I do mean “that” February intern, not all interns this month.

@drterrysimpson Well that’s an unnecessary dig at trainees

The bits of Senate hearings for Casey Means - she has the answers I would expect of a second year resident. The arrogance of one also

@BJegorovic @BradSpellberg @DrToddLee @IDiots_pod @IdVilchez @IDstewardship @CosEpiID @venkat_id @TorontoIDDoc @AntibioticDoc @tim Typically 1000 mg BID for serious infectious or bigger patients (or patients with bigger kidneys), and 500 mg BID if non-serious or smaller patients. For me it’s admittedly more “vibes-based dosing” than hard evidence.

How you dose cefadroxil? Some sources are saying 500 mg, BID (which I always used) and lately I see 1000 mg, BID for every indication. @BradSpellberg @DrToddLee @IDiots_pod @IdVilchez @IDstewardship @CosEpiID @venkat_id @TorontoIDDoc @AntibioticDoc @tim

@ABsteward Interesting that they used 24 months as the cut-off for achieving clinical cure for all comers; I’ve usually considered not achieving it by 12 months in my non-HIV infected patients as clinical failure. Not saying I disagree, just somewhat interesting.

Is three really what we need? Relative effectiveness of benzathine penicillin G and doxycycline treatment regimens for late or unknown duration syphilis in 6 United States jurisdictions, 2016–2021 #IDXposts

@ParasiteGal Nematodes and Negronis, Hookworms and Hurricanes, or Fleas and French 75s.

@PizzaJet1984 @txsportsdoc @chasedownleads Beat me to it. Rats.

@txsportsdoc @chasedownleads you need to start doing this

So local HCA hospitals are requiring reps to pay $9 for paper scrubs when thy come to hospital. For reps who go to several hosp/day this is a significant expense to them. There is also zero evidence that wearing paper scrubs or making people change scrubs lowers SSIs. Can’t stand “policies” with no evidence. Can be sure some charge nurses are empowered and made to enforce this policy. I don’t miss going to these large systems.

Opinion | I'm an Infectious Diseases Doctor. Our Pipeline of Experts Is in Distress. medpagetoday.com/opinion/second… "A world that sidelines ID now will inevitably find itself unprepared for the next microbial threats which, truthfully, are already here." well stated Boghuma K. Titanji!

@ABsteward @BradSpellberg @DrToddLee @ABsteward Wasn’t TAPER-V just 14 days of vanc vs 14 days vanc plus two week taper of same? Or are you suggesting the improvement over usual care with vancomycin probably lands it at the same recurrence rate seen in the earlier fidaxomicin studies?

@BradSpellberg @DrToddLee More effective if the cost goes down? I'm not sure it's really more effective after TAPER V!

🆕💫Longitudinal study used global pharmaceutical sales from IQVIA-MIDAS The 2021 IDSA/SHEA CDI guidelines influenced prescription patterns in Northern America promptly and gradually globally: 🔼Fidaxomicin, 🔽Oral vanco sciencedirect.com/science/articl…

@EmpiricGame I still think the “couple in bed” meme for cephalosporins was some of your best work.

The rounding team as I discuss cephalosporin generations

“If bacteria could scream, would we be so cavalier about prescribing probiotics during C. diff treatment?” -Jack Handy vs. Jack Bennett, an imaginary conversation.

@ABsteward @CMIComms @jeffpears0n @BradSpellberg @DrToddLee The article left out a very notable early-generation example, demeclocycline. It is FDA approved for mild-moderate SSTI infections, however I use it primarily off-label as an empty threat non-formulary option when the ID pharmacists don’t laugh at my jokes. @ccjozefczyk

🆕💫 Narrative Review @CMIComms @jeffpears0n Tetracyclines, the Old and the New 🔹Tetracycline 1953 ✨Doxycycline 1967 🔹Minocycline 1971 🔹Tigecycline 2005 🔹Eravacycline 2018 🔹Omadacycline 2018 #IDXposts sciencedirect.com/science/articl…

@AdamRodmanMD A little birdie gave me a heads up of your offer you made a while back…Are you still willing to give virtual Grand Rounds? We’d love to host you down in the nation’s top Greenville!

Adjunctive clinda is associated with survival in invasive GAS infections but 🔼 clindamycin resistance in GAS has called into question its durability for this indication. Linezolid also inhibits GAS toxin and virulence factor production, but clinical efficacy data remain sparse!

“Less is more, and more is CDiff…”

@EmpiricGame Of course you know what a Tim Tam Slam is…Oz? NZ? Falkland Islands?!

Would slam

@MichaelCosimini @EmpiricGame Oh boy.

this is my Twitter Personality analysis by AI Agent, built on @wordware_ai twitter.wordware.ai/Patrickenttsia…

IDSA Advocacy leads to significant new recognition of ID Physician effort in the CMS FY25 proposed Physician Fee Schedule idsociety.org/news--publicat… via @IDSAInfo

@EmpiricGame Oooo we are on-service buddies. I love a good excuse to complain.

It is happening again

Dalbavancin non-inferior to SOC in complicated SAB. Big spoiler for the highly anticipated DOTS trial. Can't wait to see these data presented next week! @ECCMID2024 @ABsteward