PEPTIDE DAILY

These numbers are shocking. It's like we got a new frontier AI model but for the body. Lilly's phase 3 results for retatrutide: > highest dose lost 28.3% of body weight in 80 wks > 70 lbs ave > 45% lost 30% or more of their body weight > 65% on the top dose no longer clinically obese Retatrutide is more dynamic than semaglutide and tirzepatide because it targets three receptors (GIP, GLP-1, and glucagon), versus one and two, respectively. Side effects, on the highest dose (12mg), were higher for retatrutide than tirzepatide (nausea and GI), with an 11.3% drop out rate. The lowest 4mg dose still delivered 19% loss with fewer dropouts than placebo.

Does BPC-157 cause cancer? Highly unlikely. Angiogenesis is not automatically bad. But it may encourage the growth of already existing cancers.

These numbers are shocking. It's like we got a new frontier AI model but for the body. Lilly's phase 3 results for retatrutide: > highest dose lost 28.3% of body weight in 80 wks > 70 lbs ave > 45% lost 30% or more of their body weight > 65% on the top dose no longer clinically obese Retatrutide is more dynamic than semaglutide and tirzepatide because it targets three receptors (GIP, GLP-1, and glucagon), versus one and two, respectively. Side effects, on the highest dose (12mg), were higher for retatrutide than tirzepatide (nausea and GI), with an 11.3% drop out rate. The lowest 4mg dose still delivered 19% loss with fewer dropouts than placebo.

15mg Tirzepatide is the max prescription dose. It’s also the strength I dispense most of. You’d think people would want to milk the most out of each dose before increasing. The reality is they max out as quickly as possible.

got my first CT w/wo contrast scan yesterday

Caught a clip from Andrew Huberman on the a16z podcast that honestly stopped me mid-scroll. He was talking about these next-gen GLP drugs—like the triple agonist retatrutide (what some call "True Tide")—and how they might quietly reshape what "being fit at a certain age" even looks like. It used to be that staying lean signaled years of hard exercise and discipline. Now, these compounds let people reach a healthy weight with less of that grind, while still sparing more muscle than the first wave of GLPs. Trials showed folks dropping up to a third of their body weight fairly fast. Wild. But Huberman's quick to say you still need to resistance train to protect that muscle—biology doesn't let you fully outsource the work. What really hit me is the societal angle. Compounding pharmacies and gray markets are already making lower doses available (not legal everywhere, but happening). He guesses in five years, over half of Americans—especially from families where obesity runs deep—could be on some version at maintenance levels. Not replacing good habits, but removing a brutal biological barrier for millions. I've seen close friends and family battle their metabolism for decades, feeling like the deck was stacked. If this tech actually delivers without nasty surprises, it could be a massive public health shift. The tension is real though: does it free people up for better lives, or just let some coast? We're at this crossroads where powerful tools meet human nature. Personal responsibility doesn't disappear, but the game changes. What do you think - will these become as everyday as morning coffee for the next generation, or will the old-school grind still hold more value in the end?