Peter Robinson🇺🇸

2.7K posts

Peter Robinson🇺🇸

Peter Robinson🇺🇸

@petervrobinson

Biotech. Startup. Improv. ChemBio PhD from Cal/Stanford. Co-founder and COO @EnableBio. Stanford-StartX/UCSF Lean Launchpad. 100% gay. He/Him.

San Francisco, CA Katılım Nisan 2016
2K Takip Edilen1.2K Takipçiler
Peter Robinson🇺🇸
Peter Robinson🇺🇸@petervrobinson·
why don't scientists just make better drugs
Jason Locasale@LocasaleLab

This is exactly the kind of hype and misrepresentation that has defined cancer research and oncology for decades. After 40+ years of work and well over $100B in taxpayer funding, what’s being presented as a revolution is a survival improvement of about 6–7 months. Patients don’t even get an additional birthday. This is now being hyped by the biotech industry and amplified by academic scientists as if it represents some fundamental breakthrough. It doesn’t. What’s even more concerning is that almost no one is calling this out. The same narrative gets repeated, the same approaches get reinforced, and the same cycle continues. Billions of taxpayer dollars will continue to fund this. Venture capital will continue to flow into biotech companies built around these claims. Pharma will continue to allocate time and resources here. Healthcare expenses for the public will continue to be greater than ever. Meanwhile, entire areas of cancer research and oncology practice—particularly early detection and prevention—remain neglected.

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Peter Robinson🇺🇸 retweetledi
alex rubinsteyn
alex rubinsteyn@iskander·
Wow, I can’t believe you can just cure cancer with ChatGPT and mRNA vaccines. The important insight was that biology is a lot like programming.
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Egan Peltan
Egan Peltan@EganPeltan·
Hey @ashleevance - thanks for the shoutout. I'm glad Rosie is doing better. A few comments: 1. At 9:45 @paul_conyngham says Rosie got a "protocol" with the "AI-designed" mRNA vax AND α-PD1 (doggy Keturda) AND a TKI (sunitinib?) AND a c-KIT inhibitor (?). What drove the response? We can't know! Before selling the mRNA vax as the key solution, bring some proof it's the "AI-designed" mRNA vax and not the doggy version of the most effective immunotherapy of all time 2. Charitably, it's possible that the mRNA vax did something as an adjuvant, but the "AI-selected" neoantigens were useless. In an N=1 setting, it's impossible to know 3. There's so much AI hype marketing material ("I used LLMs... I don't want the big labs switching off"). I'm glad LLMs could help a senior ML engineer learn how to process NGS data. But, if the story was as described - "all AI" - then why involve experts? I get that he's trying to sell an AI story - perhaps for fundraising purposes - and that's fine and all. But, there are many valid alternative interpretations This story could just as easily be ChatGPT recommending an α-PD1 (mundane). Or, some experts helping a highly motivated man find a treatment for his dog's cancer (newsworthy) Fervent belief and vibes aren't evidence. The default position here should be skepticism - using LLMs doesn't change that Lastly, it's hard to engage substantively when the details of timeline, actions, and story are unclear. I don't think Paul understands what evidence is required to support the magnitude of the claims he wants to make. As a starting point, I'd recommend asking Chat/Grok/Gemini what evidence is needed to support the mRNA vax neoantigen driven response claim
Core Memory@corememory

We did an emergency podcast with the man and dog of the hour. @paul_conyngham joined us to talk about his journey creating a personalized cancer treatment with AI for his dog Rosie youtube.com/watch?v=E0V8NA…

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Peter Robinson🇺🇸 retweetledi
Palli Thordarson
Palli Thordarson@PalliThordarson·
Proud with @UNSWRNA to have been involved & making the mRNA-LNP for Rosie. There are nuances here that the thread below misses but nevertheless, the intersection of RNA technology, genomic & AI poses an opportunity to change the way do medicine and make access more equitable 1/8
Greg Brockman@gdb

How AI empowered Paul Conyngham to create a custom mRNA vaccine to cure his dog’s cancer when she had only months to live. The first personalized cancer vaccine designed for a dog:

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Patrick Heizer
Patrick Heizer@PatrickHeizer·
Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.
Séb Krier@sebkrier

This is wild. theaustralian.com.au/business/techn…

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Peter Robinson🇺🇸
Peter Robinson🇺🇸@petervrobinson·
Sad to see scientists take heat here, as if they’re keeping a cancer drug from ppl. If u have $$, u can find someone w the *technical* ability to make a custom, hail-mary mRNA vaccine for you. They'll say tho no bc they're afraid of going to prison if it fails or you get sicker.
Ryan Bethencourt@RyanBethencourt

The Enemy isn't Big Pharma. It's the FDA and Regulators who won't allow you to test experimental therapies on yourself (or your dog). Even if it's life or death.

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Peter Robinson🇺🇸
Peter Robinson🇺🇸@petervrobinson·
@PatrickHeizer An important but underreported fact: Rosie was also co-treated with an immune checkpoint inhibitor. x.com/PalliThordarso… A heart-warming and exciting story no doubt, but hopefully the excitement fosters a pathway to more rigor, reproducibility, and regulatory reform.
Palli Thordarson@PalliThordarson

iii) It is difficult to estimate real cost in research projects as we all put in a lot of inkind time and resources. iv) the treatment required co-admin of a checkpoint inhibitor (likely to be with all personalised cancer vaccine). V) overall costs are thus quite high./3

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Patrick Heizer
Patrick Heizer@PatrickHeizer·
I literally have an ongoing cancer experiment where 100% of the untreated and control animals have had to be euthanized while 100% of the treatment animals are seemingly unaffected. But we're still extremely far away from "proving that it works." Science is hard.
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Ilya Sutskever
Ilya Sutskever@ilyasut·
It’s extremely good that Anthropic has not backed down, and it’s siginficant that OpenAI has taken a similar stance. In the future, there will be much more challenging situations of this nature, and it will be critical for the relevant leaders to rise up to the occasion, for fierce competitors to put their differences aside. Good to see that happen today.
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KING 5 Sports
KING 5 Sports@KING5Sports·
"The joke was distasteful and unfortunate...Now I have to sit in front of you...and explain someone else's behavior. It's not my responsibility." - @TeamUSA captain and Torrent forward Hilary Knight on the call and joke by President Donald Trump.
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Total NIMBY Death
Total NIMBY Death@BarneyFlames·
The NYTimes admits: The danger associated with deportations is mostly a result of blue state policies that prevent law enforcement from transferring criminal illegals to ICE custody, as a result ICE has to make "community arrests" which put citizens and legal immigrants at risk
Total NIMBY Death tweet media
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David R. Liu
David R. Liu@davidrliu·
Tonight’s episode of @60Minutes will include a segment on the impact of federally funded science and recent cuts to science funding. Our lab’s development of base editing and prime editing and their clinical applications will be among the work described in the episode. paramountpressexpress.com/cbs-news-and-s…
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Peter Robinson🇺🇸
Peter Robinson🇺🇸@petervrobinson·
@cmonjussthetip @martinmbauer Lbnl is essentially continuous with uc berkeley. Many faculty and staff are cross appointed and share facilities interchangeably. More to the point, Glenn Seaborg who led the discovery of 10 elements was unambiguously a cal professor, and later would serve as UCB chancellor.
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Ozmodiar
Ozmodiar@cmonjussthetip·
@martinmbauer Also giving credit to "UC Berkeley" for work that was done mostly at Lawrence Berkeley National Lab is somewhat dishonest.
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Jason Sheltzer
Jason Sheltzer@JSheltzer·
Dr. Yaghi did his Nobel-winning work in the US, at the University of Michigan, UCLA, and UC Berkeley. Being welcoming to immigrants helps make American science the best in the world.
The Nobel Prize@NobelPrize

This year’s chemistry laureate Omar Yaghi was born in Amman, Jordan, in 1965 to parents who were refugees from Palestine. When we spoke to him he shared his story: “I grew up in a very humble home, we were a dozen of us in one room, sharing it with the cattle that we used to raise. I was born in a family of refugees, and my parents could barely read or write. My father finished sixth grade and my mother couldn’t read or write. It’s quite a journey. Science allows you to do it. Science is the greatest equalising force in the world. Smart people, talented people, skilled people exist everywhere. That’s why we really should focus on unleashing their potential through providing them with opportunity.” Today Yaghi shared the 2025 Nobel Prize in Chemistry with Susumu Kitagawa and Richard Robson for their work developing metal–organic frameworks. Learn more about the prize: nobelprize.org/prizes/chemist…

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The Nobel Prize
The Nobel Prize@NobelPrize·
This year’s chemistry laureate Omar Yaghi was born in Amman, Jordan, in 1965 to parents who were refugees from Palestine. When we spoke to him he shared his story: “I grew up in a very humble home, we were a dozen of us in one room, sharing it with the cattle that we used to raise. I was born in a family of refugees, and my parents could barely read or write. My father finished sixth grade and my mother couldn’t read or write. It’s quite a journey. Science allows you to do it. Science is the greatest equalising force in the world. Smart people, talented people, skilled people exist everywhere. That’s why we really should focus on unleashing their potential through providing them with opportunity.” Today Yaghi shared the 2025 Nobel Prize in Chemistry with Susumu Kitagawa and Richard Robson for their work developing metal–organic frameworks. Learn more about the prize: nobelprize.org/prizes/chemist…
The Nobel Prize tweet media
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EDENT1FI
EDENT1FI@EDENT1FI·
Screening for early type 1 diabetes has officially begun in Portugal! The team is using a fresh approach to reach children directly, making screening accessible and interactive. @Decathlon
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Mireille Kamariza
Mireille Kamariza@MireilleKamariz·
Thrilled to announce our lab's first #R01 from @NIH to create cutting-edge tools for TB drug resistance detection! We have lots of work ahead, but we’re ready to dive in. Here's a snapshot of our talented PhD students at the @UCLA Molecular Biology Institute poster session 📸
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Frank Luntz
Frank Luntz@FrankLuntz·
For decades, Springfield had been another shrinking Midwestern town with an uncertain future. By most accounts, the Haitians have helped revitalize Springfield. They are assembling car engines at Honda, running vegetable-packing machines at Dole and loading boxes at distribution centers. They are paying taxes on their wages and spending money at Walmart. nytimes.com/2024/09/03/us/…
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Peter Robinson🇺🇸
Peter Robinson🇺🇸@petervrobinson·
@AHorribleGlory @FrankLuntz If immigrants make good money, they're stealing good jobs from hardworking Americans. If they don't make a lot of money, they're cheap compliant labor depressing wages of the working class. It's almost as if there's nothing that immigrants could do to avoid your contempt?
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Keşfet

@curcuas @EganPeltan @ashleevance @paul_conyngham @UNSWRNA @PatrickHeizer @TeamUSA @BarneyFlames