
The Great Contradiction in ME/CFS and Long Covid Care 🚨 Why Are We Using ‘Psychiatric’ Drugs but Still Shunning Psychiatry? Lamotrigine. Stimulants. Memantine. Guanfacine. Fluvoxamine. Clonidine. Naltrexone. NAC. Benzodiazepines ….. Why do so many medications used to target symptoms in ME/CFS and Long Covid overlap with everyday psychiatric prescribing… yet the very mention of psychiatry is shunned? Before a psychiatrist even sees them, many patients are already on layers of “medical” treatments: antihistamines, beta blockers, ivabradine, supplements, sleep agents, pain agents…… As a clinician treating these conditions what is striking for me is so many modifiable targets remain untouched because each specialty keeps viewing the problem through its own silo. Several things can be true at once: 1. Brain-body dualism is dead. 2. Many psychiatric medications have immunomodulatory, anti-inflammatory, autonomic, cognitive, and central regulatory effects. 3. Once illness becomes chronic, the brain’s predictive processing changes around that state. Expectation, salience, threat signalling, effort regulation, sleep, reward, and interoception all become part of the illness. 4. Excluding psychiatry because of past conceptual errors leaves multiple treatable targets untouched. 5. And a message for Psychiatrists - We should stop seeing ME/CFS and Long Covid as “not ours”. These conditions sit directly within our skill set, if we are willing to build the expertise. Clinicians who preserve the mind-body split only reinforce the very dualism these illnesses expose; our role is to integrate, provide clear psychoeducation about brain-body regulation.






























