Irrelevant

What sam's trying to admit here, and what the world's not ready to hear yet, is the shocking truth: GLP1s cure homosexuality. He started panicking and throwing up because he became straight and realized he was in a gay relationship with a gay dude.

Here's the simple reason ruminant meat (beef, lamb) is metabolically superior to monogastric meat (chicken, pork). Monogastrics store whatever they're fed. Grain goes in, linoleic acid ends up in the fat. Pork fat now runs around 20% PUFA. Chicken fat around 25%. The bird and the pig are, in 2026, walking vehicles for the seed oils they were finished on. Ruminants are built differently. The four-chambered stomach biohydrogenates polyunsaturated fats, converting unstable plant oils into stable saturated and monounsaturated fats before the fat is ever laid down. Grain in. Beef fat still around 2-4% PUFA. The cow eats the seed oil substrate and quietly disarms it on the way through. The pig and the chicken eat it and pass it on to whoever is eating them next. Beef and lamb: built-in detox. Pork and chicken: storage tanks for the food system you were trying to avoid. If you've cut seed oils out of the cupboard but you're still eating chicken every day, the bottle isn't gone. It's just on a plate.

We now have a female Bryan Johnson. It’s Kate Tolo. She will become the most measured female in history. +$2 million of spend per year + Developing a female-specific protocol + Sharing everything for free To start, she will spend 3 months mapping her baseline. Men, in contrast, can get their baseline done in 1 or 2 weeks. + 3 months for baseline measurement + across 4 time points per cycle + doing the same thing every day + a dedicated full-time medical team For context on the extensiveness of measurement, during the past 5 years, we’ve collected 1.5 billion data points on my body. I suspect Kate will exceed that given technology has improved since I started. The goal is to create a repeatable waveform of hundreds of life-critical biomarkers. Once the baseline is acquired, she will begin interventions. We will try to answer practically useful questions and share all of the data + learnings for free. Can fertility be improved? + Should women cold plunge? + Can PMS symptoms be alleviated? + What should a female sauna protocol be? + Should dosage change throughout the month? + What keeps a cycle regular? + Does the body need more iron, magnesium, or protein at specific phases? + Should women fast? + Should recovery protocol change by phase? + What's the earliest detectable signal of perimenopause? + Can perimenopause be slowed? + How is cognitive load & mood affected? + Does stress impact men and women the same? Kate has suspected endometriosis. 10% of all women do. We will try to tackle this too. I am excited for all of the surprising things we will hopefully uncover. Unlike me, Kate does not have the innate desire to wake up at 4:30am and do six hours of longevity therapies. She’s the cofounder of Blueprint, building in the trenches with me since day one. She understands the game and how hard it is. In many ways, this is a sacrifice for her. She is a creative person, going from a life of freedom and spontaneity to a rigid protocol. Traditionally, RCTs have been viewed as the gold standard. But RCTs have underserved women. The FDA banned women from clinical trials for 16 years (1977 to 1993), and most "medicine for women" is still medicine tested in men. Demanding RCT-only evidence for women's health is demanding evidence that doesn't exist. There is not enough practical scientific literature for women to reference only RCTs. It leaves half the population without a path to know what to do. N=1 medicine is gaining ground and picking up where RCTs specifically fail. Individual science experiments give us signals that answer what to do on a day-to-day basis. This is even more important for women. If you’re new to Kate and my world, I want you to understand that we have your back. Our intentions are to be a sturdy, reliable force in your life. To care for your best interest as we’d care for our own. We want what’s best for you and our loyalty is to your existence. It’s pretty cool to be living in a time when we may be the first generation to not die. I’m not suggesting immortality, but lifespans so long that we stop thinking about lifespans. At the end of the day, the one thing we each care about more than anything else is one more breath. I’m proud of Kate for taking on this responsibility. It’s painful, exhausting and costly. The beginning of the world’s first n=2.

The Trump administration is closing the nation's primary bee research laboratory.

$118 to fill up the truck! Let’s go! USA! 🇺🇸

Update: caught one