Ian Davis (Bluesky @profiand)

Happiness is an empty beach, the wind in your ears, your best friend by your side, and 0/8 feet on the ground

Don't miss out! The @ANZUPTrials #ANZUP26 ASM comes to #Adelaide next month. You can look at the draft program here - anzup.org.au/asm-program/. Register TODAY - anzup.org.au/asm-registrati… @BizEventsAdl @AdelaideCC @DrCraigGedye @LisaButler5 @Prof_IanD

@Papa_Heme Drug-drug interactions, and additive toxicity…

If you are diagnosed with cancer and come to an oncologist most of us will not mind if you take all the ivermectin you want. I honestly have no problem with it. But please at least hear us out with what we have to say and offer. Then you can make an informed decision for yourself

@kaomoji @SethAbramson Still waiting to find evidence of it here…

@SethAbramson Near-certain that life exists elsewhere: very likely. Intelligent life, however? We may be an anomaly.

My view = Obama's. 1. Given the vastness of the universe, it's statistically near-certain intelligent life exists elsewhere. 2. It's also statistically wildly improbable it would've come here—let alone detectably. 3. I'd be shocked if the UFO Files undermine this second premise.

@FredTaming @quotesdaily100 “Scissors as a mechanism for Darwinian selection” In this thesis I will show….

@quotesdaily100 "1. Only 10% of the world is left-handed, and nobody fully knows why." lol

LEFT-HANDED PEOPLE: 1. Only 10% of the world is left-handed, and nobody fully knows why. 2. Left-handers process language in both brain hemispheres, not just one. 3. They are statistically more likely to become artists, musicians and architects. 4. Left-handed people reach anger faster but also recover from it quicker. 5. Studies show they are better at multitasking than right-handed people. 6. Most left-handers subconsciously hide their dominant hand in social settings. 7. They are overrepresented among geniuses,Einstein, Tesla, Da Vinci were all left-handed. 8. Left-handed people dream more vividly and remember dreams more clearly. 9. They are more likely to suffer insomnia and sleep disorders. 10. The world is literally built against them,scissors, desks, keyboards were all designed for the right hand. 11. Left-handed people are more likely to be affected by fear and anxiety due to how their brain processes negative emotions. 12. Ancient cultures considered left-handedness a sign of supernatural power and witchcraft.

Geçen gün arabayla eve dönüyorduk. Önümüzdeki araba çok yavaş gidiyordu. Öfkeyle söylendim: “Niye böyle kullanıyor bu arabayı ya?” Arka koltuktan yeğenim sakin bir sesle dedi ki:++

@ethansgrumps Well done Tony

That was tough. 20 miles, 2500 feet of elevation gain, 9 hours on feet. Not too bad for an old bloke with terminal cancer and a new knee. Donations gratefully accepted to support young people living with cancer at justgiving.com/page/anthony-c…

@EHCSMonash @easternhealthau @ANZUPtrials

The @ANZUPTrials #ANZUP26 ASM comes to #Adelaide next month. Don't miss out, register TODAY - anzup.org.au/asm-registrati… @BizEventsAdl @AdelaideCC @DrCraigGedye @LisaButler5 @Prof_IanD

In #mHSPC trials, what are relevant endpoints from a clinical point of view? Presentation by @Prof_IanD @MonashHealth. #APCCC26 written coverage by @zklaassen_md @GACancerCenter > bit.ly/4efbaOe @APCCC_Lugano

🌟 PSMA dynamics as an early biomarker in mCRPC @drlouiseemmett @Prof_IanD @MartinStockler @DongNguyeb @thomashopemd @UCSF @OncoAlert A Nature Cancer study (ENZA-p substudy) shows that early PSMA upregulation (day 15) is not just a flare… it’s clinically meaningful. 🔬 Key findings: • ↑ PSMA SUV in 68% of patients after enzalutamide • With ↑ SUV:  – PSA-PFS 5.8 mo (enza) vs 13.1 mo (enza + ¹⁷⁷Lu-PSMA-617)  – HR 0.38 → clear benefit with radioligand therapy • With ↓ SUV: no significant difference between arms ⚡ Interpretation: Early PSMA increase may identify a poor-response phenotype to ARSI alone 👉 but also a targetable window for PSMA-directed therapy 💡 Take-home: This is not progression… 👉 it’s biology revealing vulnerability Are we ready to use early PSMA dynamics to guide treatment intensification? 👀 @PhillipKooMD @BannerHealth @JournalofNucMed 🔗 doi.org/10.1038/s43018… #ProstateCancer #mCRPC #PSMA #Theranostics #PrecisionOncology #OncoTwitter

Only 3 days left to apply for the @ANZUPtrials Study Coordinator Scholarship. Successful applicants will receive a complimentary registration to our #ANZUP26 ASM in #Adelaide from 28-30 June. Applications close on Friday 24 April! anzup.org.au/awards-and-gra… @BizEventsAdl @AdelaideCC

@YouAreLobbyLud @jenna_taglienti This is something we all need to understand better.

@jenna_taglienti I've always found it profoundly comforting. It means I don't feel as if I have to carry the weight of the world on my shoulders. I can just do my best, try and help out where I can and be a valuable part of the machine, but it doesn't all fall apart if I'm not there.

On the first day of my medical house job in 1991, the registrar said to me: "You will quickly start to think you're irreplaceable. You're not. Remember that. If you get hit by a bus tomorrow, the consultant will look round and say 'Didn't we used to have a house officer? Get me another one!'"

Predictive value of early PSMA upregulation for the response to enzalutamide ± 177Lu-PSMA-617 in poor-risk, metastatic, castration-resistant prostate cancer: substudy of the randomized, phase 2 ENZA-p trial nature.com/articles/s4301… In mCRPC, PSMA expression changes early with enzalutamide. In the ENZA-p trial, 68% of patients showed increased📈 PSMA PET SUV by day 15. This rise predicted shorter PSA progression-free survival with enzalutamide alone. However, adding 177Lu-PSMA-617 significantly improved outcomes in these patients, mitigating this adverse prognostic effect. Early PSMA SUV dynamics may serve as a predictive biomarker to guide combination therapy strategies in mCRPC. #ProstateCancer @drlouiseemmett @shalsubra @WeickhardtOnc @szetinglee1 @davcmed @thomashopemd @NarjessAyati @DrMHofman @SandhuShahneen @MartinStockler @Prof_IanD @OncoAlert 🚨 @Silke_Gillessen @AOmlin @weoncologists

@JoeBerne1 The best Star Wars movie (by parsecs) was a prequel, and the best SW series was a prequel to that.

My hot take for today: Prequels. If a prequel adds anything to the story, the main series wasn't good. If they don't, the prequel isn't good. You should be able to figure out the backstory, more or less, from what happens in the main series.

@HeartOTXHeartMD @DutchRojas Or phone zombies. I confess to at least one occasion where I allowed one to plough straight into me.

@DutchRojas Amen. I frequently comment to my wife about that, …and people walking 4-abreast on the sidewalk who don’t file up for oncoming traffic. One day, when my frontal lobe is done, there could be a forearm shiver in those people’s future. 😬🤣

If you're walking into a store and someone is walking out, they have the right of way. Momentum. Visibility. Hands full. It's the same logic as elevators. We've collectively forgotten how doors work.

@VickersBiostats Now you’re going to have to sit in on your cousin’s date and report back. You’ll have to pay for your own meal. You can be in disguise if you want although some restaurants don’t allow disguises.

Time to bring back a classic! I asked a journal editor for a date. She declined, but said I could date her sister if I paid $4,000.

Are you coming to the #ANZUP26 ASM in #Adelaide this June? @ANZUPTrials have partnered with @Qantas to offer special flight discounts. Read more on our website: anzup.org.au/asm-registrati… @BizEventsAdl @AdelaideCC

@barttels2 @RahulBanerjeeMD What’s Prince Harry got to do… what? Oh. Never mind.

@RahulBanerjeeMD Mabs v ibs; injection v oral; large v small; extra cellular v intracellular. Fun with suffixes.

A big step forward for the pancreatic cancer field - congrats to all on the RASolute 302 trial! Looking forward to hearing full daraxonrasib data. As a myeloma doctor, a second "dara" drug will bring some confusion... but this is a huge step forward for patients with panc CA!

Also don't forget to contact me if you want to be part of the GU Oncology starter pack: go.bsky.app/DtoXvaD

Many thanks. Here are the #ASCO26 sessions at a glance, 2-page view. Friday and Tuesday put together at the end, as they are shorter days and I can only include 4 images.