pureion
586 posts

pureion
@pureion
Not a Cognitive System Architect First Principle Thinker






@StuartHameroff He has a point wrt 'measurable'. Science is rarely (never?) truth, rather it's useful. I guess IIT has utility?



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Palmer Luckey might be the only billionaire in Silicon Valley willing to say this out loud.




Yes, resonance with spacetime geometry Platonic values is the suggestion. Roger Penrose wrote an article about this with his Oxford colleague Paul Tod. I can’t find it now but they used the Schrödinger-Newton equation.


Meyer–Overton is just a correlation though. It doesn’t point to a single target, and definitely not specifically to tubulin. The “one target” idea kinda fell apart because anesthetics clearly hit multiple systems GABA, NMDA, K2P, etc. And those effects have actually been tested directly and line up with people losing and regaining consciousness. That’s the difference for me. Those mechanisms show up in real brains, you can measure them, tweak them, and watch behavior change. The tubulin side just isn’t there yet. Right now it’s mostly correlations and modeling, but no clear demonstration that anesthetics are actually disrupting microtubules in living neurons in a way that tracks consciousness. That’s the gap. Saying Orch OR predicts it is one thing, but until it shows up clearly in vivo, it’s not really competing with what we already know it’s just layered on top. So it’s not about bias, it’s just a simple check. If tubulin is the main thing, it should show up clearly. So far it doesn’t.





















