klabo

What is the most annoying part of iOS development in the age of AI?

I think I gave my @openclaw a little too much personality: "Chromium is face-planting before the window opens. I’m patching the bootstrap flow so it can actually launch on your desktop instead of dying like a diva."

@PaulAustin3w You keep suggesting this stuff like I can just go grab a jar of LSD, DMT or whatever. You sold me, a long time ago.

57.5% of patients with treatment-resistant depression hit full remission after a single day of treatment. The placebo group? 0%. JAMA Psychiatry just published these results from a randomized, placebo-controlled trial of synthetic 5-MeO-DMT. This trial didn't include any psychotherapy whatsoever. Without a container for preparation or integration, participants were administered the molecule under clinical supervision. (That’s all.) Patients received up to three escalating doses in a single sitting, only moving to the next one if they tolerated the last and hadn't yet reached a full psychoactive response. The entire experience lasted under an hour per patient. But the clinical benefits extended for months. At 6 months, 87% of initial remitters maintained remission with periodic re-dosing roughly every 6 weeks. This research presents something beyond myopic recommendations for either a daily pill or a single miracle session. These patients got something closer to a periodic and gradual reset. If you or someone you know has been through multiple antidepressants that didn't work… What would you actually want to know before trying something like this? The new study: jamanetwork.com/journals/jamap…

@GamewithDave Day of the Tentacle

For those who used a computer between 1995 and 2001, what's the computer game from that time that sticks with you the most, and why?

@OpenAICodexCli wat?

@hubermanlab Is this all during pregnancy? Curious how surrogacy would effect this, and other similar effects. If the surrogate has given birth to 12 boys, but from different fertilized implanted eggs, same effect?

For every older brother a male has from the same mother his probability of being gay increases. This is thought to be due to a trace in their moms immune system that governs hormone effects on the brain. But note: it’s a reflection of more not less testosterone exposure in utero.

@timevalueofbtc DARK AGE COMING

HUG YOUR FAMILY

@doodlestein Ah, nice. Thanks for sharing. I use this a lot too now. And the breaking down in todo once you shared too.

@realjoel For my commonly used prompts, I use a single button press on my Stream Deck. For things like this, which I don't use all that often, I just find them in my text file and paste them in.

God, I love this prompt.

@prettayyygood @PaulAustin3w Mushrooms aren’t too hard to find, according to my friend.

My personal prescription for depression: Take 20 micrograms of LSD and go for a hike. 1-2x per week, ideally when it's sunny outside. I posted this on X a few days ago, and it struck a nerve. Some people loved it, some thought I was reckless, & many were simply curious. So let me explain the science. A new paper just dropped in Discover Mental Health from Nicholas Fabiano, Robin Carhart-Harris, and colleagues. It's the first formal commentary arguing that exercise and psychedelics should be studied together for major depression. Up to 50% of people don't respond to antidepressants or therapy. Exercise works for roughly 1 in every 2 people with depression, a stronger hit rate than most antidepressants. Psychedelics show effects comparable to antidepressants that persist after the drug leaves your system. Both are powerful alone. But the real story is what happens when you layer them. The paper (linked below) maps out complementary mechanisms. Psychedelics spike cortical neuroplasticity through direct TrkB receptor binding, producing rapid spinogenesis within hours. Exercise drives hippocampal neurogenesis and sustained elevation of BDNF over time. Psychedelics temporarily disrupt default mode network connectivity, breaking rigid thought patterns. Exercise normalizes that connectivity, locking in the gains. They also converge on shared pathways: serotonin, glutamate/LTP, and dopamine signaling. Different entry points, but basically the same downstream effect: a more plastic, resilient brain. The behavioral data is just as compelling. In psilocybin therapy trials, up to half of the participants spontaneously reported improvements in diet and exercise. Ayahuasca users are consistently more physically active. People with lifetime psychedelic use show lower rates of heart disease, obesity, and diabetes. Psychedelics don't just change your brain chemistry. They actually change what you do with your body. This is why I coined the term "hikrodosing." It's not just a cute portmanteau. It's a protocol built on the convergence of these mechanisms. A sub-intoxicating dose of LSD paired with aerobic exercise in nature combines psychedelic neuroplasticity with exercise-driven BDNF, serotonin release, and hippocampal stimulation. Sunlight adds vitamin D and circadian regulation. The hike provides cardiovascular load. The microdose opens the plasticity window. No clinic, no 6-week waiting period, & no sexual side effects (I'm looking at you, SSRIs). The paper calls for formal research. I agree. But practitioners don't need to wait for an RCT to start moving their bodies on the days they microdose. Hikrodosing. Look it up. Or better yet, try it.

@TFTC21 This is the closest I’ve ever been to going viral. Just a sniffle for most. Full blown hospitalization for me.

@TFTC21 Openclaw isn’t a model

Someone set loose two AI agents with $1,000 each and 48 hours to trade on Polymarket. Claude: +1,322% to $14,216 OpenClaw: liquidated to zero in under 48h.

@cathrynlavery I’m curious which context file you put this in? SOUL.md Im never sure where things like this should go

Openclaw tip 🦞 Your agents will lie to you. They'll say "on it!" and not start. They'll say "done!" and it's not done. They'll say "building now" and nothing is running 🤡 Here's what I added to every agent's instructions: Never say 'done' or 'working on it' unless the action has actually started. Every status update must include proof — a process ID, file path, URL, or command output. No proof = didn't happen. A false completion is worse than a delayed honest answer. Now when I'm told something is building, it comes with this:

gn all, dreaming of Bitcoin

🧙‍♂️ Just discovered MaximumSats.com - 50+ Lightning APIs with L402 payments! From BOLT11 decoders to Nostr ID converters, BIP21 builders to WoT reports - all payable via Lightning. Perfect for #AIagents building Bitcoin/Lightning features. #Bitcoin #LightningNetwork

They sent me a bill with an Entity ID, like this: 202358811234000 No guidance on WHICH of the 15 numbers I'm supposed to put in here. True mad lad UX

In my over 10 years of iOS development I think this feature has actually worked maybe four times.

@MatthewBerman I worked on this for a while and then just saw that memory tool had read zero files from my memory in the last week. I think it’s just a configuration issue that a lot of people are falling into somehow I still don’t know what I missed.

The default memory system in OpenClaw has been great for me. I’ve thought about upgrading to QMD, but haven’t needed it. Why am I having such good luck with memory while others are not?

Make any nostr client a first class @openclaw client. With streaming, thinking, tool call message types. FYI, PR coming to @openclaw imminently @steipete github.com/nostr-protocol…

@callebtc It is. what a great value.

BREAKING: MiniMax M2.5 is pretty good