Gordon Rix

I have been selling magnetic racks and magnetic beads for several years now. Magnetic racks are about 65% of sales. Magnetic beads for DNA purification are only 9%. I assume that you use the racks mainly for DNA purification. Am I wrong? If not, is there something wrong with my beads? I would expect much more magnetic beads sales. I would greatly appreciate to learn why you would not choose my beads. Price too high? Or too low? Too good to be true? You tested the sample of beads with NEB ladder and it didn't work? Something else?

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…

In this work, we bring OrthoRep’s mutation rate up to 10^-4 substitutions per base, allowing us to durably hypermutate and evolve chosen genes in vivo at 1-million times the genomic mutation rate of the host yeast cell. What does this afford? biorxiv.org/content/10.110…

Let me show you how to DOUBLE your sequence throughput and read length using this one weird trick. @nanopore HATES this.

New experiment this week for COB... I'm releasing a new software tool + an accompanying essay 🧬 Learn more about *The Interactive Mutation Browser*

WE👏 ARE👏AWARE👏THE👏LOGO👏LOOKS👏LIKE👏A👏BEARDED👏DUDE👏IN👏AN👏ORANGE👏HAT👏 —YOU👏DO👏NOT👏NEED👏TO👏KEEP👏POINTING👏THAT👏OUT👏EVERY👏SINGLE👏DAY👏

Never forget: the people telling you that fedoras don't look awesome, are people who think you don't deserve to look that good.

ML for bio is fed all the DNA sequences of nature and makes a beautiful glowing enzyme ML for tech is fed all the content from the internet and makes a toxic psycho chatbot As you choose your next career moves remember that you have to live in the world you build

@spleonard1 Definitely don't put the entire plate including the polystyrene into a blender with some LB, homogenize, and then filter the paste through a Buchner funnel and culture the filtrate... unless...?

🍞 >>>>>>>

I'm excited to announce the release of our hardware-agnostic interface to liquid-handling robots, PyLabRobot. PyLabRobot provides a common language for communicating with different types of robots in Python. Github repo: github.com/pylabrobot/pyl… youtube.com/watch?v=s808Eg…

@Grippingfoods those tomatoes are not being gripped very forcefully

@pdhsu Definitely agree with everyone saying it varies a lot, but just to add a concrete example: from a recent experiment I got 2.5 million reads for a 3.4 kb amplicon with the first use of an R10.4 flow cell using the LSK-112 kit

Finding it remarkably hard to figure out Nanopore's read depth. Where can I find this?

New this week! In vivo continuous evolution takes advantage of cycles of rapid mutation, amplification and selection inside living cells @cnb_csic @CSIC @Beatriz_Al_Go @lafdez_synbio @chang_c_liu @haiqi_chen @UTSWScience @francesarnold @zerlinia go.nature.com/3FXKnCK

@chorye yes! probably won't be me, but I'll certainly be shilling the idea to every new lab recruit 😁

@rix_gordon Thanks Gordon! Maybe we could try to get it up and running with yeast?! 😉

this is INCREDIBLE. Everyone who didn't get me a Christmas gift this year, it's not too late...

Today, we present peCHYRON, a DNA recorder that propagates an unending chain of insertions. Each link contains a randomizable 3-bp “signature” sequence that serves to record a cellular event. The result: temporally-resolved cellular event recording! 1/12 biorxiv.org/cgi/content/sh…

Happy to share that our OrthoRep-driven transcriptional biosensor evolution work is now published in @ACSSynBio. Congrats to Alex Javanpour! pubs.acs.org/doi/10.1021/ac…