sam (tabone) rector

Had a blast chatting with @DaveMessina about what we look for when underwriting early stage biotech, what techbio is, and more. Listen here >>> youtube.com/watch?v=tAFydT… @XEIA_VP @pioneer_fund

The recent @ataibeckley and @EliLillyandCo news is a big deal. It seems that the big pharmas with neuroscience franchises have placed their fully hallucinogenic bets. A totally unexpected thing. The next question is how much these strategics will double down on the next generation drugs. I’ve heard many whispers of large Newleos and Neumora inspired raises around something that represents the revised TPPs spread across multiple therapeutic hypotheses and all I can think about is how we’re going to have a crowded landscape of newly approved drugs in neuropsychiatry again. Who will dominate commercially? I have my theories and we’ve placed our bets (and will continue to do so) at @XEIA_VP Whether it’s a truly differentiated and tailored TPP (@Xylo_Bio) or a technology positioned to disrupt prescribing patterns (@KernelCo), the next ten years are going to be extremely interesting. Stay tuned.

Pretty stoked to see our @XEIA_VP portco @coherenceneuro on this pod. Shout out to @WoodingtonBen, @Elise__Jenkins and their team for being absolutely legendary.

Love building @coherenceneuro

@davieball @genomecomputer I went to a party in SF once where someone offered me guests to have their genome sequenced. The founder ghosted. Can I try again with you guys?

San Francisco! Join us for our second ever Genome Party and get your whole genome sequenced for free. Follow @genomecomputer and reply 🧬 so we can DM you. If we can’t offer you a spot, we’ll send you something special. Thursday, July 23 6–8pm. Limited to 20 total spots.

The other day my husband posted about women with tattoos on X. It was a pro women with tattoos post. The comments on it were hilarious and at first, I thought they might all be bots. But some of them weren’t. Genuinely concerned about the volume of men still obsessed with harboring misogyny as a core and sometimes primary part of their identity. It’s at first comical to see, but upon inspection, it’s quite frightening that even in a relatively “progressive” part of the world, there’s an aggressive amount of self-loathing losers that spend all day whining about how women suck just because they don’t get attention. How does this overlap with the psychopathology of the manosphere if at all? Educate me.

@Grimezsz @bryan_johnson jumping movements

@bryan_johnson What's the best thing for the bone density besides lifting?

I’m 48, my body composition resembles a 20 yr old > bone mineral density 99.6th percentile > body fat of 11.3% > lean mass: 160.1 lbs On these markers, better than >90% of men in their 20s

I'm back. With the main goal of not burning out again.

Today, I shared with the OpenAI team that I have decided to leave my full-time role at OpenAI and transition to being a part-time advisor. Three months ago, I had to go on medical leave after a severe exacerbation of a chronic illness I’ve lived with for seven years. During that time, it became clear that the road to recovery would be much longer and more complex than I had anticipated—and that I needed to focus on it fully. When I went on leave, many people told me I was courageous for prioritizing my health. The truth is that I am only making this decision now because I failed to make it many times before. Over the years, doctors, friends, colleagues, and loved ones encouraged me to slow down. Two years after I got sick, Facebook offered me the opportunity to take a full year of medical leave. I didn’t even pause to consider it. I immediately said no. At the time, Zuck told me I should play the long game. I wish I had listened. Looking back, I realize that a lot of what made me successful also made this decision incredibly difficult. I grew up believing that opportunities were precious and that when they appeared, you grabbed them with both hands. That mindset carried me from a small town in southern France to opportunities I never could have imagined. By the time I turned 40, I had already gotten to do more than I’d ever dreamed possible as a kid growing up in Sète. I love building. My work has always given me a deep sense of purpose. OpenAI in particular felt like a role that my entire career had been building toward, which made this decision even harder. But what I’m learning now is that grit and endurance are not the only skills required to have impact over decades. Sometimes the harder thing is to stop, listen, and trust that taking care of yourself today makes it possible to contribute for much longer tomorrow. This experience has also strengthened my conviction about why this work matters. It has been a jarring experience to spend my days helping build the future while simultaneously navigating a disabling disease that still has no cure. Over the last seven years, I’ve spent countless hours in doctors’ offices, dealing with symptoms, treatments, insurance, uncertainty, and all the invisible work that comes with being a patient. Like millions of others living with chronic illness, I’ve experienced firsthand how difficult healthcare can be to navigate, even when you have every possible advantage. More than ever, I believe that some of the most important opportunities for AI lie in helping people solve real problems in their daily lives: their health, their finances, their time and the everyday burdens that shape human experience. In particular, curing disease is the most important thing AI could accomplish. I’m excited to continue working towards cures through OpenAI but also through my work with @ChronicleBioAI and @CODA_research. I’m deeply grateful to @sama, @gdb and the OpenAI board for their support during this time and for offering a way for me to continue contributing to the mission without sacrificing my chances of recovery. I’m also so thankful to my team and the many extraordinary colleagues I’ve had the privilege to build alongside. For now, my focus is recovery. But my belief in the potential of technology to solve deeply human problems has never been stronger.

@therealbrom sorry lol

@samalanascience can confirm

Getting a period for the first time in five years is wild.

Frontier AI companies as biotech acquirers nature.com/articles/s4158…

I used to not like tattoos on women because i was an insecure idiot, and then I wifed up a heavily tattood baddie and life has never been better

Hungry every 2.5 hours Immediate anti-bloating effect Dysautonomia returns 1 pseudo loss of consciousness episode induced by POTS Sudden, extreme fatigue. Slept fourteen hours in one day.

Readjusting to my natural hormone cycle after IUD removal has been insane. Ask me anything?