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@therealbrom

Founding partner at @XEIA_VP Building Human 3

San Francisco, CA Katılım Kasım 2010
548 Takip Edilen6.2K Takipçiler
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brom
brom@therealbrom·
Excited to announce @focalpointlp's "Human 3" thesis: the era of exponential human flourishing. While modern medicine (Human 2) benefited society in incalculable ways, it ultimately fell short of its promise because the available tools forced it to operate at an incremental pace with long feedback loops. Today, exponential technologies like AI - which can parse through terabytes of scientific literature and data in seconds - and brain-computer-interfaces, biosensors and CRISPR - which enable real-time, read-write access to our biology - promise to rapidly accelerate the scientific method flywheel and lead to an exponential explosion in health, wellness and performance. Human 3 will elevate every area of health and wellbeing, but will have the biggest impact in areas where modern medicine has made the least progress: the mental health crisis, neurodegeneration, chronic disease and aging. These are the “focal points” of our investment strategy. Human 3 is not a “sector” - our companies combine life sciences, AI, hardware, software, deep tech & health tech in novel ways that often defy conventional categorization. Human 3 is a philosophy of vitality. It is a knowing that the “user experience” of the human body and mind is long overdue for an upgrade. It is the willingness to build and invest in that future. This is Human 3. This movement marks the third great epoch of human health: - Human 1 was defined by medieval practices like bloodletting and humorism - medicine before evidence. - Human 2 was the era of “modern” medicine, which began in the 1850s when Louis Pasteur popularized the germ theory of disease and the scientific method became the gold standard. Human 2 was constrained by both incremental tools and artificial boundaries between disciplines. - Human 3 builds on Human 2’s legacy of scientific rigour, but is accelerated by exponential technologies, transdisciplinary collaborations, and driven by a belief that we can do so much more to not just heal the sick, but to prevent illness in the first place and elevate the already healthy. We’ve already backed some of Human 3’s genre-defining companies like @KernaLabs , @motifneuro, @Psylo_Bio, NeuroBionics, Kadence Bio, @superpower and Aperture Therapeutics, at their earliest stages. We’ve helped them secure pharma partnerships, hire their best talent and raise millions in follow-on financing and we’re just getting started. If you're a founder starting something in Human 3, we hope you'll consider working with @samalanascience and me.
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Patrick Malone, MD PhD
Patrick Malone, MD PhD@patricksmalone·
prediction: AI scientists will eventually devote more compute to forecasting scientific outcomes on prediction markets than producing scientific papers. as AI makes scientific content effectively infinite, publication will stop being a meaningful signal. economic incentives will increasingly reward verifying scientific facts, not simply producing more content and papers.
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sam (tabone) rector
sam (tabone) rector@samalanascience·
Getting a period for the first time in five years is wild.
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brom
brom@therealbrom·
I used to not like tattoos on women because i was an insecure idiot, and then I wifed up a heavily tattood baddie and life has never been better
Justin Murphy@jmrphy

The currently fashionable male view of tattoos on women is a hysterical herd phenomenon, which pretends to be some kind of sophisticated anthropological "red pill"—except it's obviously wrong. The meme says "tattoo = red flag" and "no tattoo has ever made a woman more beautiful." These two observations are contradictory. What none of the Men Against Female Tattoos ever acknowledge is: Red Flags are Hot. Red flags are not predictors of stability, faithfulness, or sustainable compounding of value, but not all the attractions of human life are perfectly correlated with the preferences of uptight Anglo shopkeepers. The most sexually attractive traits are correlated with a propensity toward self-destruction: risk, recklessness, and self-endangerment, even to the point of death. Read Freud, Bataille, or even within evo-psych just look at Life History Theory. Self-destruction has always been one of the sexiest things in the world—and for good reasons, even if it cuts against long-term stability. It may be true that one tattoo rarely makes a woman more beautiful (in part because one tattoo has little signal either way), but what this popular refrain ignores is the following inconvenient fact: Many tattoos can make a woman far more attractive. If you've ever been to a bar at night (many of these men have not), the hottest woman there (according to the actual felt sense of lust averaged across all the men), will ALWAYS be the wild-looking, heavily tattooed baddie over the pristine girl in a sundress, assuming other traits are equal. If any of these anti-tattoo men were approached by one of these women below, in a bar past 11pm, they would simply wet their pants. They would not be able to handle it, and they've never had the opportunity, either. And I think they know that this is true, which is why they hysterically project against any woman with ANY SINGLE tattoo, with this weirdly intellectualized gloss that folds if you even poke it for a second. Men who love to talk about their zero-tolerance policy for tattoos on women are often just boring, fearful, cowardly men who know nothing of romance, love, sex, or death. All they care about is securing a loyal safe obedient slave who is guaranteed to never put their long-term value accretion at risk. This is also why many of them never get married at all, or stay perpetually divorced; and the ones who are married are often just uptight bores and petty tyrants over boring, lame little households. Can we also talk about how this anti-tattoo hysteria is itself a kind of inverted woke feminism—it's so prissy, so fixated on "trauma" (which is probably not real, and a left-wing bludgeon), etc. Sorry bros but the theory presented here is far more consistent with the data. It's OK to have your own preferences; you don't have to dress them up as profound social theories, which conveniently also frame yourself as a good person, and women you could never get as bad people!

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brom
brom@therealbrom·
You want Bob
Ramsay Brown@_ramsaybrown

@UseMissionCtrl has been working on something new that I'm very excited to share with you. We want to save the 1,000,000 years of industrial expertise that retire per day. To do that, I'm proud to introduce you to Bob, our first hardware device. youtu.be/llwWwxrQA1I

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sam (tabone) rector
sam (tabone) rector@samalanascience·
My goal is to never take a call again. No calls. Antisocial. Introvert. Text me.
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brom
brom@therealbrom·
It’s true. No peptide, no creatine, no hrt - just adventure and cultivating a lust for life
sam (tabone) rector@samalanascience

At @XEIA_VP we’ve discovered the true NOzempic longevity hack. My co-GP-now-husband was complaining that I was making “too many treats” near our wedding in December. According to him, I helped him gain 30 pounds. Seen left, buzz lightyear Brom in peak nesting form. Seen right, six months later. It seems that beer, swimming, sun, staying up late, and the occasional vape sesh seem to be working wonders. We’ll keep you posted on his progress.

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brom
brom@therealbrom·
> my wife and I stopped by Corgi Cafe on Friday night to check the hype > place was absolutely packed, there were two guys sitting nearly on top of each other in a phone booth because there were no seats > three women in total: the barista, my wife, and a girl who was trying to get work done but kept getting hit on by a guy in a suit who told he her owned the cafe ☠️
(AK) Akshit | Epoch Protocol 🦇🔊🛡️@OstwalAk

Corgi single-handedly is the best coworking cafe/space in my opinion. I’ve been in SF for a week now and couldn’t find anything better than this cafe. It’s 11 PM Friday night in SF, and this is the vibe at Corgi Cafe. They offer high-protein smoothies (42g), with Chipotle and Subway nearby. The cafe is open 24/7 and has good WiFi. What else do you need?? Gonna miss this energy and place in NYC so much

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Caroline Toch
Caroline Toch@carolinetoch·
This is me screaming into the void but does anyone actually like their fund formation lawyer if so who are u!!!
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brom
brom@therealbrom·
being in Chicago for a few days has made me realize how insanely early we are in the GLP-1 adoption cycle
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brom
brom@therealbrom·
@_ramsaybrown Roses are red, violets are blue . . .
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Ramsay Brown
Ramsay Brown@_ramsaybrown·
you guys remember the stochastic parrot era of discourse? That was wild.
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brom
brom@therealbrom·
Fellas, I hate to be the bearer of bad news, but most girls don’t want a skinny peptide boy
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brom
brom@therealbrom·
@iPaulLee when I was raising my first fund, I thought that lowering fees would help me get commitments, but not once did I ever speak to an LP who was like 'I wont invest, but I will if you lower the fees'
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Paul Lee
Paul Lee@iPaulLee·
1/ Hot take: For Fund I, it’s ok to consider giving up carry and fees to get into business.
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brom
brom@therealbrom·
A great look at @coherenceneuro, a company we've been backing since 2024. Coherence is actually building something useful for a real market; the thousands of people who get diagnosed with glioblastoma - one of the deadliest brain cancers - each year.
Sachin and Adam@Sachin_and_Adam

We got exclusive access to the startup building BCI’s for brain cancer survival Two Cambridge engineers, @WoodingtonBen & @Elise__Jenkins, taking their SOMA-1 implant to human trials this month This episode profiles @coherenceneuro and their Palo Alto research lab (featuring a live BCI mice demo) to learn about this new form of cancer treatment Chapters 0:00 What is glioblastoma cancer? 3:17 Meet the founders - Ben & Elise 5:55 Inside the SOMA-1 device 6:56 How Coherence Neuro started 9:35 Why this technology is needed ASAP 11:22 Live Demo: Inside Coherence's Lab 14:53 Why MRIs (and other current tech) isn't good enough 15:50 When will patients have access to SOMA-1? 17:30 A future where cancer isn't terminal

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brom
brom@therealbrom·
@alexkshieh @AntifraudCo this is pretty cool, but would be even more based if it was focused on suing the government when they defraud the american people
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Alex Shieh
Alex Shieh@alexkshieh·
I guess I'm a Thiel Fellow now?! I'm building AI models at @AntifraudCo to catch fraudsters who defraud the American taxpayers. We're qui tam laws to sue the fraudsters directly, and keep 15-30% of the recovery. Today, some fraudster's day got a bit worse... (also we're hiring!)
Thiel Fellowship@thielfellowship

Welcome 2026 Thiel Fellows! WHO ARE THEY? Victor Boyd: Birmingham, AL - @VictorWBoyd Cavalla is on a mission to get anything anywhere in under 5 hours. Starting by building autonomous forklifts, through to developing hypersonic highways. Samuel Carvalho: Recife, Brazil - @samuelclcc Praso is building the new infrastructure for wholesale commerce — powering procurement, credit, and workflow tools for SMBs across underserved areas in Brazil. Nick Dobroshinsky: Sammamish, WA - @NDobroshinsky EveryTicker is democratizing institutional-grade financial research across the entire U.S. stock market, including the thousands of smaller companies Wall Street ignores. Ishan Gupta: Kanpur, India - @ishangpta Juicebox is building an AI recruiter that helps companies make better hiring decisions. Agents that understand real skills and move hiring from guesswork to true meritocracy. Antoni Kiszka: Strzyżowice, Poland - @antoni_kiszka Derpetual is building the infrastructure to create a market for any asset — with leverage. Milan Lustig: Cold Spring Harbor, NY - @HighPriestOfSWO Opt32 is building modern compute infrastructure to put AI onboard objects in the physical world — from robots to cars and drones. Galen Mead: Chapel Hill, NC - @g413n Standard Intelligence is building aligned general learners, pretraining large models to actively explore and learn from the Internet. Aubrey Niederhoffer: New York, NY - @needaubrey Swoop is building the super app for Africa, starting with food delivery in Nigeria and expanding into financial services across the continent. Harry O'Connor: Cork, Ireland - @HarryOC493 Sentient Machines is a research lab building foundational models for robotics that generalize across tasks and environments. Alex Shieh: Salem, NH - @alexkshieh The Antifraud Company is a fraud bounty hunter defending American taxpayers with AI and investigative journalism. Claire Wang: Los Angeles, CA - @clairebookworm Claire is building biologically accurate simulations of entire nervous systems, starting with C. elegans. Developing a simulated brain that researchers can communicate with helps lay the foundation for brain-computer interface (BCI) technology. Kyler Wang: Portland, OR - @kylerywang Action is an artificial intelligence company in stealth.

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