Dr. Sheridan Littleton

215 posts

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Dr. Sheridan Littleton

Dr. Sheridan Littleton

@sciencesheri

Genetics and appetite regulation. Postdoc at Cambridge @IMS_MRL with @GilesYeo. NC State BS ‘18 and UPenn PhD ‘24 (she/her)

Cambridge, England Katılım Nisan 2019
284 Takip Edilen241 Takipçiler
Dr. Sheridan Littleton
Dr. Sheridan Littleton@sciencesheri·
My first postdoc paper! Reviewing the latest single-cell discoveries from the hypothalamus and our ongoing efforts to understand such a complex and important brain region 🧠🧬
John Tadross@JohnTadross

Delighted to share our open-access review with @sciencesheri & @GilesYeo on hypothalamic feeding circuits—how single-cell, spatial and 3D atlases link cellular identity to function. @IMS_MRL #hypothalamus #singlecell link.springer.com/article/10.100…

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Dr. Sheridan Littleton
Dr. Sheridan Littleton@sciencesheri·
This was the first experiment I designed during my PhD and led to my most surprising bit of data so it’ll always have a special place in my heart 🩷
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Leonardo Jo
Leonardo Jo@leonardojo·
It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!
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Arjun Raj
Arjun Raj@arjunrajlab·
In basketball, shoot for threes instead of long twos. For NIH grants, shoot for two long aims instead of three.
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GETUP-UAW Local 5124
GETUP-UAW Local 5124@GETUPgrads·
WE WON! This week, over 2000 Penn grad workers cast ballots. After eligible votes were tallied, the final count was 1807 to 97. It's official. The majority of eligible voters turned out to the polls. Penn graduate workers have resoundingly declared: WE WANT A UNION AT PENN!
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Cell Genomics
Cell Genomics@CellGenomics·
Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2 dlvr.it/T6Kr1x
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Dr. Sheridan Littleton
Dr. Sheridan Littleton@sciencesheri·
@brandon_logeman @CellGenomics The few papers on Faim2 KO mice were focused on neuro and immune phenotypes and while one reported a trend of increased fat content, none showed significant differences in body weight. I’d love to see what happens if they’re offered a high fat diet!
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Brandon Logeman
Brandon Logeman@brandon_logeman·
@sciencesheri @CellGenomics The change in cell proportions during differentiation is interesting, especially given FAIM2's role in apoptosis. Do you know what the phenotype of a FAIM2 KO mouse looks like?
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Dr. Sheridan Littleton
Dr. Sheridan Littleton@sciencesheri·
Our hypothesis is that FAIM2 is required for normal appetite-suppressing neuron development/survival during childhood and decreased FAIM2 contributes to increased obesity risk at a young age (3/4)
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Dr. Sheridan Littleton
Dr. Sheridan Littleton@sciencesheri·
science fail journal entry 13: ejected a pipette tip into my reagent bottle instead of my waste bucket
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Giles Yeo
Giles Yeo@GilesYeo·
👇Our new findings out in @NatureGenet today, where we report 2 new genes linked to adult-onset obesity. In particular, variation in Bassoon results in the largest effect on body-weight seen at the population level to date! #genetics #obesity #obesityisnotachoice
IMS Epidemiology, University of Cambridge@imsepidemiology

Rare gene variants identified by @ZhaoDylan and @The_MRC colleagues have the largest impacts on obesity risk discovered to date. The BSN & APBA1 variants are among the first for which increased risk of obesity isn't observed until adulthood. mrc-epid.cam.ac.uk/blog/2024/04/0… 🧵(1/6)

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Keşfet

@Nature @IMS_MRL @Cambridge_Uni @MPI_Metabolism @STARProtocols @arjunrajlab @KhanhBTrang @kieonacook