Yajie Zhao, 赵亚杰

1/n New preprint! varTFBridge combines statistical association and fine-mapping with functional predictive models (VAR2TFBS, ABC-FP-Max, AlphaGenome) to trace common AND rare noncoding variants to the TFs and genes they affect. (1/) 📄 biorxiv.org/content/10.648…

We just updated our manuscript: biorxiv.org/content/10.648…

Spring in Beijing

The GTEx v10 eQTL data have been integrated into the SMR portal: yanglab.westlake.edu.cn/smr-portal/

Great to the see the flurry of single gene knockdown Perturb-seq like atlases from cell-lines, mouse brain etc over the last few days. These are undoubtedly very valuable datasets. I just want to re-iterate a few other very important expt. design considerations 1/

Great work led by @JasonLinjc. This work was hugely benefited from the new FOODIE technology developed by XieLab @XieSunney. Many thanks for the mechanistic insight from AlphaGenome for non-coding variants @Avsecz, and again to the UK Biobank participants.

8/n Code and pipeline are open-source. Give it a try! 🔗 github.com/JasonLinjc/var…

1/n New preprint! varTFBridge combines statistical association and fine-mapping with functional predictive models (VAR2TFBS, ABC-FP-Max, AlphaGenome) to trace common AND rare noncoding variants to the TFs and genes they affect. (1/) 📄 biorxiv.org/content/10.648…

Glad to share the collaborative work from XieLab @XieSunney and our lab.

Blue Hour in Beijing

Great work! Congrats Prof @hesheng3 and team!

It’s time to rethink Parkinson’s disease. Our work reframes PD as a disorder of the somato-cognitive action network (SCAN), and shows that normalization of SCAN connectivity represents a shared mechanism across diverse effective therapies. nature.com/articles/s4158… @ndosenbach @DavidRen555 @iamzhangvv @bttyeo @foxmdphd

@KexinHuang5 @a16z @MenloVentures @AnthropicAI Congrats Kexin!

Today we’re launching Phylo, a research lab studying agentic biology, backed by a $13.5M seed round co-led by @a16z and @MenloVentures / Anthology Fund @AnthropicAI. We’re also introducing a research preview of Biomni Lab, the first Integrated Biology Environment (IBE), where we’re imagining a new way biologists work. Biomni Lab uses agents to orchestrate hundreds of biological databases, software tools, molecular AI models, expert workflows, and even external research services in one workspace, supporting research end-to-end from question to experiment to result. Agents handle the mechanics, while you define the question, then review, steer, and decide. Scientists end up spending more time on science: asking questions, understanding mechanisms, and eliminating diseases. Phylo (@phylo_bio) is a spin-out of @ProjectBiomni, where we will maintain the open-source community and push open-science research. I’m grateful to continue building with my co-founders @YuanhaoQ @jure @lecong and the dream founding team @serena2z @TianweiShe @huangzixin20151 @gm2123 @margaretwhua @malayhgandhi. We’re also fortunate to be advised by leading scientists @zhangf, Carolyn Bertozzi, and @fabian_theis, and supported by an amazing group of investors including @JorgeCondeBio @zakdoric Matt Kraning @ZettaVentures @dreidco @conviction @saranormous @svangel @valkyrie_vc and others. Biomni Lab is available for free today: biomni.phylo.bio Learn more in our launch post: phylo.bio/blog/company-f… We are also hosting launch events - join us at South San Francisco: luma.com/n8k8qb0n Virtual: luma.com/l5ryjaij We’re also hiring! phylo.bio/careers

Double Helix@CPL

Sunrise & Sunset