Steffen Klein

Don’t miss this incredible opportunity to learn about in situ CLEM and connect with amazing people. Join us for engaging lectures and hands-on training sessions!🔬❄️#EMBOCLEM embl.org/about/info/cou…

Aaaaand we're live! Excited that our paper "De novo design of protein structure and function with RFdiffusion" is available online @Nature Check out the accompanying news article for how it's being used already, and for a few hints at where this story might be going next 😉

New preprint is live! See how @barrettmpowell conjured #tomoDRGN. Barrett’s heroic effort now gives us one of the key tools needed to visualize structural heterogeneity in cells. Excited for folks to give it a whirl and let us know how it goes. 1/n

Motivated by our recent collaborations with @ChlandaL on fusion of enveloped viruses, we systematically analyzed the role of curvature in the fusion of spherical and tubular membranes. Our paper is open access and now out in @BiophysJ at doi.org/10.1016/j.bpj.…

New research from the Mahamid and Savitski groups at EMBL Heidelberg shows how cellular stress can cause the Mumps virus to reactivate. The findings can help scientists better understand RNA virus replication and inform future drug targeting strategies. cell.com/cell/fulltext/…

Das Virus in eine Falle locken: Heidelberger Forscher beschreiben Mechanismen, die bei der Verhinderung von Infektionen durch Influenza-A- und Ebola-Viren eine Rolle spielen könnten uni-heidelberg.de/de/newsroom/da…

I am thrilled to share that our latest effort on the unconventionally FGF2 secretion pathway is finally out as a @biorxiv preprint! We found that Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space!🧵 biorxiv.org/content/10.110…

IFITM3 sorts lipids to block viruses. IFITM3 modulates local lipid membrane composition, blocking #influenza virus endosomal entry by stabilizing viral membrane fusion in hemifusion state @steffen_kl @GolaniGonen @FabioLolicato @ChlandaL cell.com/cell-host-micr…

I am very proud that my Ph.D. work was published today in @cellhostmicrobe. I want to thank my amazing Ph.D. supervisor @ChlandaL for the last four years and for everything he taught me! Thanks to all collaborators, and especially @GolaniGonen & @FabioLolicato. #TeamTomo #CLEM

Genetically encoded multimeric tags for intracellular protein localisation in cryo-EM biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Happy to introduce our new API to simplify the design and implement as tion of FIB/SEM automated pipelines. This is just the start...a lot more is about to come 🙂 Please download it and give us feedback or submit requests biorxiv.org/content/10.110…

Congrats, Liv 😊

Delighted to present AlphaDesign, a computational tool for #SyntheticBiology that builds on #AlphaFold to design novel proteins with diverse folds, as binders and fold-switchers. With @majendrusch @JanKorbel5 @embl biorxiv.org/content/10.110…

Glad to share our new paper on exploring the limits of cryo-ET. We elucidate how the translation machinery in a simple bacterial cell work, from the near-atomic detail to a whole landscape picture. And what happen when perturbed by antibiotics. check out #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

@nani_grotjahn @GolaniGonen @FabioLolicato @SchwabYannick @NickelLab @SchwarzUlrich @ChlandaL Hey Danielle! Thank you 😊

@steffen_kl @GolaniGonen @FabioLolicato @SchwabYannick @NickelLab @SchwarzUlrich @ChlandaL Congrats Steffen! 🎉

I am excited to share our work over the past years on the mechanism of the antiviral protein #IFITM3. It was an incredible journey. Thanks to everyone involved! @GolaniGonen, @FabioLolicato, #BrittaBrügger, @SchwabYannick, @NickelLab, @SchwarzUlrich, @ChlandaL #TeamTomo #cryoET

@gopaperboats @GolaniGonen @FabioLolicato @SchwabYannick @NickelLab @SchwarzUlrich @ChlandaL Thanks a lot 😀

@steffen_kl @GolaniGonen @FabioLolicato @SchwabYannick @NickelLab @SchwarzUlrich @ChlandaL Congratulations Steffen! :)

Congrats Paula! Great work 😀

So excited about our preprint on the role of matrix proteins during Ebola virus entry! Thanks a lot for this amazing collaborative work! :) @GolaniGonen @FabioLolicato @MVallbracht Keerthi, Christian, @SamySIDAHMED2, the Brügger, Hoenen & Fackler labs, @NickelLab,@SchwarzUlrich

Our manuscript describing the cryo-EM structures of Cx43 gap junction channel and hemichannel is now on bioRxiv. biorxiv.org/content/10.110…