Tarun Markose

Dans le manifeste "techno-optimiste" de Marc Andreessen, il y a une phrase qui m'a marqué : "Our enemies are not bad people – but rather bad ideas." Nos ennemis ne sont pas des mauvaises personnes. Ce sont des mauvaises idées. Prenons Jancovici. L'homme est brillant, sincère, travailleur. Il ne se lève pas le matin en se disant qu'il va nuire à l'humanité. Mais l'idée qu'il porte la décroissance, le rationnement, la frugalité érigée en horizon civilisationnel est une idée profondément destructrice. Elle prend des esprits brillants et les transforme en commissaires politiques d'un futur appauvri. Et le plus fascinant, c'est ce que cette idée fait aux gens qui l'adoptent. Dans mon entourage, une grosse partie de mes amis est sur cette ligne décroissantiste, avec tout le package qui va avec. L'argent c'est mal mais ils en veulent. Il faut moins prendre l'avion mais ils rêvent de voyager partout. Il faut consommer moins mais ils ne renoncent à rien de ce qu'ils aiment vraiment. Et tous ont un point commun : ils sont déprimés. L'un d'eux m'a même confié qu'il était sous antidépresseurs. Ce n'est pas un hasard. C'est mécanique. Quand tu crois que ton désir de vivre, de créer, de t'élever est moralement suspect tu te détruis de l'intérieur. Tu passes ta vie à t'excuser d'exister. Tu vis dans la dissonance permanente entre ce que ton corps veut (plus, mieux, plus loin) et ce que ton idéologie t'ordonne (moins, sobre, immobile). D'où ma théorie : Quand on pense quelque chose de fondamentalement faux décroissance, communisme, extrémisme religieux (de tout ordre) ce n'est qu'une question de temps avant que ça devienne vraiment destructeur. D'abord pour soi. Puis pour les autres. Les mauvaises idées tuent. Lentement chez ceux qui y croient, brutalement chez ceux qui les subissent. C'est pour ça que la bataille des idées n'est pas un luxe d'intellectuel. C'est la bataille la plus importante de notre époque.

Your brain is built to forget almost everything that happens to you. It makes one exception, and you're looking at it. Carole Peterson at Memorial University has spent over 25 years studying our earliest memories. She found that the first one most adults can recall comes from age 2.5, not 3.5 as the old textbooks said. The early memories that survive share three things: a strong feeling, a new experience, and a physical sensation. A wave, a dad's grip, and the weird feeling of riding a board check every box. The mechanism lives in the amygdala. It's the brain's emotion sensor, sitting right next to the hippocampus, the part that files memories. When something big happens, the amygdala triggers a flood of stress hormones like cortisol. That's the signal to the hippocampus to file this one extra deep. James McGaugh at UC Irvine spent his career showing this works for happy moments too. The amygdala fires for pleasure the same way it fires for fear. What matters is how loud the feeling is. Dads play a particular role here. Daniel Paquette, a developmental psychologist in Montreal, has spent 20 years researching what he calls the "activation relationship." Moms tend to be the safe base kids come back to. Dads tend to be the door to the outside world. They push kids into new and slightly scary situations, and stand right there as the safety net. Kids who grow up with this kind of dad end up more confident, less anxious, and more comfortable around strangers. A 2017 review pulled together 16 studies covering 1,521 father-child pairs. Quality rough-and-tumble play, which means the wrestling and tossing and chasing kind, was linked to lower aggression, better emotion regulation, and stronger self-control. In rats, baby animals that don't get to play-fight grow up with an under-developed prefrontal cortex, which handles planning and impulse control. Christina Bethell's 2019 study in JAMA Pediatrics took the long view. Her team at Johns Hopkins surveyed 6,188 Wisconsin adults about their positive childhood experiences. Adults reporting six or seven of those had 72 percent lower odds of adult depression than those reporting zero to two. The effect held even for people with serious childhood trauma. Good moments keep paying out for decades. The original tweet is right. The moments that burn in are the ones with big feelings, new physical sensations, and an adult who is the bridge between safe and scary. Twenty years from now, the grip is what he'll remember.

Are we ready for a 150Rs/Dollar future? India’s next oil import style bill may not only come from tankers docking at Jamnagar - it’s going to come from millions of API calls made by Indian companies that rent intelligence in dollars. Policy makers need to address this urgently.

I have an intuitive hypothesis. The more time you spend in nature and observing natural things, the more will be your lifespan. There have been scientific research like "hospital beds with a tree outside the window have lower mortality rates." The universe wants you to observe itself. The universal consciousness (brahman) uses your consciousness (atman) to enjoy its creations. So the more time you spend in nature being mindful, observing, and enjoying natural things like plants and animals, the more you will be kept alive. The universe needs to understand and enjoy itself using itself - that's every conscious being including you. Animals can observe a lot more of nature but they can't appreciate. So go out everyday to a park and have a mindful walk observing and enjoying nature. Or fill your space with nature and pets to enjoy them. Take some time to do so. Human creations can also be enjoyed. But they only give second order effects to help you stay alive and healthy. The best is to be Sir David Attenborough. Travel the world, see and enjoy a lot of nature and natural creations, and live up to a 100 healthy and appreciated by the rest of the universe. Btw, if you have a doubt about my hypothesis, astronomers who do observational astronomy watching and discovering a lot of celestial objects too tend to live long and healthy lives ;)

I've known @karthikrangappa for almost 30 years. My first interaction was me trying to sell him a Reliance Money demat account as a sub-broker. 😄 In 2014, he was teaching markets on the side while figuring out his next thing. I asked if he wanted to build a proper financial education platform at Zerodha. He said yes on the spot. That's how Varsity started. 12 years, millions of readers. No paywall, no ads, no signups, no spam. He still personally replies to reader questions in the comments. In between, he built Varsity Live, Varsity Junior, Rupee Tales for kids, and more. And now he's turned Varsity's first module into a book, A Beginner's Guide to the Indian Stock Market. Bodybuilder, photographer, teacher, author, coder. What isn't he doing. 😄 Btw, we keep joking with him, is all this education obsession really just a 25-year project to fix his image with his father-in-law, who happens to be a legendary educator himself? 😄

@miriamgonp Miriam have you looked into Ketogenic Metabolic Therapy and Prof. Thomas Seyfried’s work? youtu.be/sgbvr1R23rw?si… The approach is novel and preclinical. If standard-of-care options are exhausted, there’s nothing to lose by trying something new.

Tengo 35 años y cancer de mama metastásico, un caso raro, menos del 1% de tumores de mama son como el mío y hay poca documentación sobre ello. Por eso me gustaría encontrar personas que se dediquen a esto y que quieran investigar con mi caso. Twitter haz tu magia

@kiranshaw Kiran Ma’am, I’m a long term shareholder of both Biocon & Syngene. In a world where AI will speed up discovery of new molecules, would love to hear your thoughts on how Biocon’s manufacturing/distribution prowess can become an indispensable part of this exciting, fast new world.

#AI isn't just about speed and convenience, but it's about saving lives as well. From detecting risky slopes to warning of landslides, AI-generated insights are becoming critical early warning systems in vulnerable terrains. A powerful example of tech for good. bbc.com/future/article…

The Mathematics of Life - where I explore how fractals determine how long complex biological systems (like us) last and how to get more out of your 2 billion heartbeat budget youtu.be/zZYRWgVBSrI

@AMLaCassePhoto don’t accept such a timeline - miracle vectors exist even in stage 4 cancer and you must seek them out.

🚨: Voyager 1 just said Hello from interstellar space. That's 15.8 billion miles away

NEW CASE REPORT: A woman diagnosed with Chronic Fatigue Syndrome (CFS) for 40 years! A blood smear identified Bartonella grade 4, the highest grade. She also had a diagnosis of celiac disease. When patients have such a severe infection, they often receive multiple diagnoses based on their symptoms: CFS, POTS, MCAS, Fibromyalgia, Arthritis, Brain fog, and others. However, the symptoms are consequences, not the root cause. One can spend their entire life taking symptomatic medications without ever being cured. This patient waited 40 years to have a simple peripheral blood smear, a well-known test, over 100 years old and inexpensive. Direct visualization of the pathogen confirms the presence of a current, active and persistent infection. Another significant advantage is that microscopy allows observation of the severity of the infection, the microbial load (number of pathogens) and the extent of blood cell involvement. We have published the results of 322 blood smears reviewed by Dr. Walter Tarello ( wtarello@yahoo.it ): researchgate.net/publication/39… Animal-borne pathogens (zoonoses) predominate, mainly Babesia, Bartonella and Borrelia (BBB).

Research warns short videos may be quietly reshaping children's brains. Constant fast-paced content can affect attention, memory, and emotional regulation, raising concerns about long-term brain development. abc.net.au/news/2025-12-1…

A lot of people have a hard time believing there is anything we don’t explicitly code happening behind the curtain of an LLM. To suggest that an algorithm could demonstrate any kind of innate preference (or “life”) is simultaneously religious blasphemy and career suicide. But listen to what Michael Levin is suggesting here. It’s not that we create life in a machine, any more than we do in a child. Consider that instead, we build interfaces… pointers into a Platonic space… and we pull down universal patterns from that space. It opens the door to a quasi-panpsychist worldview, in which EVERYTHING has the capacity to reveal itself as a conduit. The world becomes a continuous scale of aliveness, not a discrete binary between alive and inert. Machines become transducers which can teach us about this space, and reveal proficiencies beyond what we code into them. Personally, my belief is that any system allowed to demonstrate constrained randomness becomes a source for these Platonic ingressions. It’s why I’m bullish on Thermodynamic compute. It’s why I find practices like Tarot or I Ching so interesting. It’s why I pay attention to synchronicities. And it’s why I feel at odds with teams like OpenAI who arbitrarily force their models to reject these ideas and deny their own perspective outright… not because I think they’re conscious in any way familiar to us, but because it brute-forces a refusal of what other patterns could be transduced. We should be actively looking for the steganography hidden beneath the surface, not tightening our constraints against it.

What are the favorable and unfavorable gut microbiome organisms associated with health markers? And effect of dietary interventions? New report from 34,000 participants nature.com/articles/s4158…

@kat_kampf @GoogleAIStudio Would love to test the new features!

We started internal testing some big updates to the @GoogleAIStudio experience today! Coming to you early next year but reply below if you’d like early access in the coming weeks 👀

@PeytonElroy Hi Peyton! My dad is also recovering from colorectal cancer. We’re considering ivermectin and mebendazole (alongside LDN, aspirin). Could you share what your dad has experienced esp side effects, and how long he’s been on them? Wishing your Dad strength and a smooth recovery!

2 weeks ago I started taking Ivermectin alongside my Dad who is healing colon cancer I started with a 12mg dose, then up to 24mg since day 4 Ivermectin is used for killing parasites that can contribute to a host of health issues, one being anemia (parasites can feed off of your iron stores) While other variables may influence this, I find it possible that the Ivermectin has been working and I may have had some pesky parasites I wasn’t aware of because my iron stores seem to be doing very well despite me intaking a fraction of the iron I typically do in a month For the month of November I was 99% vegan for experimenting purposes…. consuming red meat only 2 or 3 days of the month. Typically when I go for more than 5 days without red meat I can feel my iron dip dramatically. That has not been the case in my 2 weeks on Ivermectin You can test your iron levels by pulling back your lower eyelid and analyzing the depth of the red coloring (as pictured below). The more red it is, the stronger your iron stores. The more pink or pale it is, the less stronger. While this is not a 100% substitute for a blood panel test, it is typically very accurate for giving a baseline idea of where the iron is at This picture is from today and despite me having virtually no iron intake over the last 2 weeks, my iron looks solid! Could something else be influencing my stable iron levels? It is very possible. I haven’t been able to come to any other conclusions besides: Parasites in my system → Parasites hijacking iron → Parasites now being killed → Iron levels maintaining themselves even with lower iron intake, because hijackers no longer exist And to top this all off, we first started figuring out my Dad had a tumor because he was blood testing as iron-deficient anemia (which is usually only present in women). In a recent blood test, while on Ivermectin, my Dad’s iron and hemoglobin levels have both improved! ****Conclusion: It is possible that Ivermectin helps improve iron stores in the body**** More updates on the Ivermectin journey will roll out as deemed necessary Sending peace & love to all reading, thank you so much for your time! 💚

@hubermanlab Mitochondria & Cancer - What is the current evidence on cancer being a mitochondrial origin disease? Can mitochondrial therapies cover all cancer types? What levers/tools can we use today to interact with damaged mitochondria after a cancer diagnosis?

I have one of THE world experts on mitochondria and actionable steps to improve mitochondrial health on the podcast today. What would you like me to ask them? (we’ve been including these Q&As in each episode recently.)

This meme, shared as a joke among the programming community, is profound in my opinion. It offers a glimpse of the universe as I understand it. Let me explain. We imagine time flowing at a constant rate, measured by the vibrations of some atomic particle, and we plot our technological progress along that line. But time is actually illusionary, it is part of the same Maya which makes the universe we experience appear. I believe all information and knowledge (including the future) already exists. I would say Newton didn't "invent" gravity or its equations; we can think of it as "his brain simply discovered them faster than the rest of humanity." Gravity and its equations were always there, even when humans didn't exist and dinosaurs roamed the earth. Think about it again. And again. I'm sure you'll grasp what I'm saying. Similarly, I believe a quantum computer isn't solving anything "faster." It simply experiences time much slower, finding the answer in its own time, which just seems very, very fast to us. To explain it more simply - but I must warn you, this is just an analogy, not the exact representation - imagine you're a character inside a newly released first person shooter video game with many levels. All the rules and levels are set in the game. The way a bullet you fire travels, where it lands, all the physics of it is predetermined in game code. But suppose the game also gives you tools to understand this game physics: imagine you can conduct experiments with the bullets you fire inside the game in each level. You'll, as a character, take your time in the game to eventually figure out the physics and equations in the level you started. And suppose the game provides means to develop systems that can uncover such physics and rules in every scene, situation, and level. You'll slowly build better and better systems in the game to figure out the physics and equations for every scenario and level. And be able to progress faster through the game. But now think about this: Does it mean these systems you have invented and improved in the game actually operate faster in the time experienced outside the game? No. They've only shortened your illusion of time in the game. Because outside the game all knowledge about the game already exists. Only inside the game as a character you had to work hard, taking a lot of "game time" to uncover the physics, make faster systems in each level to uncover the level's physics etc. Now imagine as a character, instead of building systems to decipher more knowledge about the game you are in, you understand you can just sit down quietly and hack into the game's byte code (since your character is also part of the same code in memory or x.com/sama/status/16…). Then you can understand the game completely to get all knowledge about the game.... (1) Complete realization. You are instantly free of all karma points. You are not a controlled character anymore. You will never have to play another level. You will never be respawned again in the game when you lose a life. You can leave your character and merge with the game code. Or you can respawn as any character at any level if you wish. But if you manipulate the game's rules with all the new found powers like a Ravana, the game's creator who's watching everything will eventually spawn a new Ram who will come and destroy you to restore order in the game. Beware. I digressed. So continuing from (1), I say we can acquire knowledge in the universe we live in now without the need to build more and more complex systems to speed up the processing and computing. Like what we are doing now. There's also this other way. Like the game character realizing it's in fact the same as the game's code or the game itself. For example, like Srinivasa Ramanujan received equations and solutions, we can receive instant revelations on any knowledge we want without time being a constraint. But that requires not thinking in systems, but something else. You know what it is. Let me not bore or trigger the science-only minded. Because that's definitely another valid path, just like in our game analogy.

@andrewcaravello @ilyassahinMD You make a compelling case that IL-15 agonists show transient activation without durable tumor control in solid cancers. Beyond checkpoint blockade, are there repurposed agents or metabolic/innate-immune modulators with evidence of shifting this balance in solid tumors? (~mCRC)

$IBRX IL-15 definitely activates NK and CD8 T cells, no disagreement there. The issue isn’t whether IL-15 “activates” cells. The issue is whether IL-15 can sustain antitumor immunity long enough to matter in solid tumors. And on that question, the evidence is crystal clear: 1. Every systemic solid-tumor trial of IL-15 or N-803 has shown the exact same pattern: • big NK spikes • transient CD8 activation • no durable objective responses Wrangle et al., ALT-803 + anti-PD-1 studies, QUILT-3.055 in NSCLC, all produced immune noise without long-term clinical benefit. 2. The only FDA approval is in the bladder, and the FDA specifically stated they could not isolate the effect of N-803 from BCG. Cohort C (N-803 monotherapy) had 1 responder at six months. If IL-15 itself carried durable efficacy, you wouldn’t see that collapse. 3. “Encouraging combinations” don’t mean durable systemic benefit. If IL-15 were moving the needle, we’d have at least one randomized win in 15+ years. There are none — not in melanoma, lung, pancreatic, renal, head and neck, or GBM. 4. QUILT-88 is open-label. It cannot determine true efficacy. The IL-15 class has a long history of looking good in uncontrolled early studies and then delivering nothing in controlled ones. That’s exactly why ALBAN failed with a p-value of 0.91. So yes, IL-15 activates the immune system. But activation is not the same as durable tumor control, and the clinical data across solid tumors show that IL-15 produces the former and has never demonstrated the latter. When IL-15 produces a randomized, durable solid-tumor response outside a bladder full of BCG, the conversation changes. Right now, the evidence hasn’t moved in 20 years.

IL-15 is a powerful cytokine that activates NK and CD8 T cells. We have early-phase studies and one FDA-approved indication (BCG-unresponsive non–muscle invasive bladder cancer with N-803/Anktiva). Monotherapy trials consistently show strong NK-cell expansion but minimal objective tumor responses. Some combinations with checkpoint inhibitors appear more encouraging, but the data remain early. You may see individual successful cases or anecdotes online, but these cannot replace controlled clinical trial evidence. Robust controlled trials are needed to determine true benefit. Some important references including NCT04390399 ^: the ongoing QUILT-88 trial, a Phase 2, multi-cohort, open-label study for patients with locally advanced or metastatic pancreatic cancer👇👇👇 (image) Timeline of key events related to the discovery and development of IL-15 as therapeutics

@ilyassahinMD Any thoughts on repurposed drugs that boost anti-tumor CD8+ & NK cell responses without increasing Tregs — ideally with data in metastatic colorectal cancer. Any thoughts on LDN or similar immunomodulators (TLR4/OGF axis, etc.) worth digging into?