Daniel Shur

Today I am launching the Free Radicals podcast with @EricDai_BioE . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host @celinehalioua, Founder + CEO @loyalfordogs, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, @EricDai_BioE and @FreeRadicalsBio for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS

@ArtirKel @RetroBio_ Apple Podcasts: podcasts.apple.com/us/podcast/lon…

@ArtirKel @RetroBio_ Spotify: open.spotify.com/episode/33k3DR…

Today’s guest on the Free Radicals podcast is @ArtirKel, head of theory @RetroBio_ and blogger nintil.com. Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by @a16z, @WorksInProgMag and @ASI. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story

@onsoc63 @ArtirKel @RetroBio_ Hey @onsoc63 ! Check it out here: youtu.be/uaqVOukx-qI

@teleodaniel @ArtirKel @RetroBio_ yt link?

@ricomnl @RetroBio_ Transcript on Substack: freeradicalspodcast.substack.com/p/inside-the-a…

@ricomnl @RetroBio_ Apple Podcasts: podcasts.apple.com/us/podcast/ins…

Today’s guest on the Free Radicals podcast is @ricomnl, head of applied AI @retrobio_. Retro was seeded with $180M by OpenAI CEO Sam Altman to develop therapies to prevent and reverse age-related disease, and is widely recognized as one of the leading AI for longevity companies. This was a fun conversation about Retro’s work with OpenAI to engineer 50x more efficient Yamanaka factors in a matter of months, what it means to build foundation models that can reason across natural language and protein sequence, and why the bottlenecks in biology are more experimental than computational. We also get into the biology of aging and how AI can enable therapies that dramatically advance healthy lifespan. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 1:42 Engineering transcription factors for more efficient reprogramming 19:02 How protein models are used 30:40 Exciting developments in protein engineering 36:20 Challenges in predicting protein behavior 39:38 Do scaling laws apply to protein models? 43:41 How these models are useful for longevity 56:15 Existing pathways for damage repair in the body 1:03:07 Will superintelligence solve aging for us?

The aging field is so small that one talented scientist joining it can have an outsized impact on progress. @impetusgrants finds those scientists. The EBV work below is a case in point. @MartinBJensen: "If we assume an uneven distribution of ability, and you're really good and in the top 10%, you joining the aging field could be half a percent more progress. Just one person." @ Free Radicals podcast, @EricDai_BioE + @teleodaniel

Today’s guest on the Free Radicals podcast is Christopher Bradley, founder of @matterbio. Christopher is a serial entrepreneur who has dedicated himself to solving aging after his last startup Mana Health was acquired by NBC Universal. His company Matter Bio is developing therapies to enhance DNA damage repair to slow the rate of aging, and to treat cancer through novel bacterial delivery mechanisms. They've raised over $9M for this purpose from investors including Lifespan Vision Ventures and @quadrascope. In today’s conversation we discuss the theory of aging as information loss, which Chris contends is primarily mediated through DNA damage, how to unlock new approaches for longevity through large scale genomics studies, and the evolving business of biotech. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:13 Largest study ever of genes for longevity 06:49 DNA damage as a driver of aging 14:10 Counter-arguments against the DNA thesis 25:16 Cancer isn't aging 27:53 How Matter Bio is targeting DNA damage to extend lifespan 35:15 Stem cell therapies 41:03 Different pathways for managing DNA damage 50:28 Sex ed (or what we can learn from germline rejuvenation) 55:14 What to expect from Matter Bio in the future 57:36 How to make longevity therapies as visual as rocket launches 1:00:35 The business of biotech 1:06:47 The importance of longevity as a moonshot 1:09:31 Sequencing techniques 1:12:02 What is it like working with co-founder George Church 1:16:02 Navigating the volatile industry of biotech

@RaianyRomanni Transcript on Substack: freeradicalspodcast.substack.com/p/the-moral-an…

@RaianyRomanni Apple Podcasts: podcasts.apple.com/us/podcast/fre…

Today’s guest on the Free Radicals podcast is @RaianyRomanni. Raiany is a Harvard and Brown-trained bioethicist focused on understanding why secular people like to narrate death and aging as good things, and quantifying the economic impacts of such narratives. Our conversation focuses on the ethics and economics of longevity. Listen to hear the moral case for delaying aging, why it’s not a “luxury problem” and much more! More info on Raiany: she worked with legends like George Church and Steven Pinker on her PhD, and also played a central role in designing the $101 million dollar XPRIZE for Healthspan, the largest science prize ever awarded. She is the founder of a new think tank designed to study and streamline progress in America’s science and technology, and most recently published a paper demonstrating that delaying overall biological aging by just one year could yield $27 trillion dollars in net present value. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:44 Daniel and Eric discuss their takeaways 8:35 Raiany explains the economic impact of longevity 13:08 The connection between ethics and economics 17:20 The importance and failures of bioethics in the modern age 20:28 Objection to longevity #1: nature knows best 25:07 Are the pharma companies heroes or villains? 29:31 Objection to longevity #2: overpopulations 30:20 Objection to longevity #3: vampire billionaires and tyrants 30:20 Objection to longevity #4: vampire billionaires and tyrant 31:52 Objection to longevity #5: cultural stagnation 33:28 The importance of human agency 41:01 How to influence the culture and policy 46:30 Objection to longevity #6: longevity is full of snake oil salesmen 49:20 US-China and the race to longevity 52:43 Evidence that aging is malleable 58:00 Eric and Daniel open up about their relationships 1:02:48 Is longevity a “luxury problem”? 1:06:21 The greatest crisis facing our generation

@elander777 @RaianyRomanni Thank you @elander777 !! Really appreciate the support!

@teleodaniel @RaianyRomanni I know that you don't have a lot of followers yet, but you are putting out some really good stuff. Keep up the good work!

@RaianyRomanni Likewise!! Thank you for joining us on the podcast!

@teleodaniel Genuinely loved speaking with you! Thanks for the fun questions.