Free Radicals (@FreeRadicalsBio) - Twitter Profili

Free Radicals retweetledi

José Luis Ricón Fernández de la Puente@ArtirKel·3d

I have recorded a bunch of podcasts, but this last one is my favorite one so far. We talked about longevity, but also many of my other niche interests x.com/teleodaniel/st…

Daniel Shur@teleodaniel

Today’s guest on the Free Radicals podcast is @ArtirKel, head of theory @RetroBio_ and blogger nintil.com. Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by @a16z, @WorksInProgMag and @ASI. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story

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Free Radicals retweetledi

Daniel Shur@teleodaniel·3d

Today’s guest on the Free Radicals podcast is @ArtirKel, head of theory @RetroBio_ and blogger nintil.com. Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by @a16z, @WorksInProgMag and @ASI. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story

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Free Radicals retweetledi

Daniel Shur@teleodaniel·10 Mar

Today’s guest on the Free Radicals podcast is @ricomnl, head of applied AI @retrobio_. Retro was seeded with $180M by OpenAI CEO Sam Altman to develop therapies to prevent and reverse age-related disease, and is widely recognized as one of the leading AI for longevity companies. This was a fun conversation about Retro’s work with OpenAI to engineer 50x more efficient Yamanaka factors in a matter of months, what it means to build foundation models that can reason across natural language and protein sequence, and why the bottlenecks in biology are more experimental than computational. We also get into the biology of aging and how AI can enable therapies that dramatically advance healthy lifespan. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 1:42 Engineering transcription factors for more efficient reprogramming 19:02 How protein models are used 30:40 Exciting developments in protein engineering 36:20 Challenges in predicting protein behavior 39:38 Do scaling laws apply to protein models? 43:41 How these models are useful for longevity 56:15 Existing pathways for damage repair in the body 1:03:07 Will superintelligence solve aging for us?

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Free Radicals retweetledi

Daniel Shur@teleodaniel·3 Mar

Today’s guest on the Free Radicals podcast is Christopher Bradley, founder of @matterbio. Christopher is a serial entrepreneur who has dedicated himself to solving aging after his last startup Mana Health was acquired by NBC Universal. His company Matter Bio is developing therapies to enhance DNA damage repair to slow the rate of aging, and to treat cancer through novel bacterial delivery mechanisms. They've raised over $9M for this purpose from investors including Lifespan Vision Ventures and @quadrascope. In today’s conversation we discuss the theory of aging as information loss, which Chris contends is primarily mediated through DNA damage, how to unlock new approaches for longevity through large scale genomics studies, and the evolving business of biotech. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:13 Largest study ever of genes for longevity 06:49 DNA damage as a driver of aging 14:10 Counter-arguments against the DNA thesis 25:16 Cancer isn't aging 27:53 How Matter Bio is targeting DNA damage to extend lifespan 35:15 Stem cell therapies 41:03 Different pathways for managing DNA damage 50:28 Sex ed (or what we can learn from germline rejuvenation) 55:14 What to expect from Matter Bio in the future 57:36 How to make longevity therapies as visual as rocket launches 1:00:35 The business of biotech 1:06:47 The importance of longevity as a moonshot 1:09:31 Sequencing techniques 1:12:02 What is it like working with co-founder George Church 1:16:02 Navigating the volatile industry of biotech

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Free Radicals retweetledi

Daniel Shur@teleodaniel·24 Şub

Today’s guest on the Free Radicals podcast is @RaianyRomanni. Raiany is a Harvard and Brown-trained bioethicist focused on understanding why secular people like to narrate death and aging as good things, and quantifying the economic impacts of such narratives. Our conversation focuses on the ethics and economics of longevity. Listen to hear the moral case for delaying aging, why it’s not a “luxury problem” and much more! More info on Raiany: she worked with legends like George Church and Steven Pinker on her PhD, and also played a central role in designing the $101 million dollar XPRIZE for Healthspan, the largest science prize ever awarded. She is the founder of a new think tank designed to study and streamline progress in America’s science and technology, and most recently published a paper demonstrating that delaying overall biological aging by just one year could yield $27 trillion dollars in net present value. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:44 Daniel and Eric discuss their takeaways 8:35 Raiany explains the economic impact of longevity 13:08 The connection between ethics and economics 17:20 The importance and failures of bioethics in the modern age 20:28 Objection to longevity #1: nature knows best 25:07 Are the pharma companies heroes or villains? 29:31 Objection to longevity #2: overpopulations 30:20 Objection to longevity #3: vampire billionaires and tyrants 30:20 Objection to longevity #4: vampire billionaires and tyrant 31:52 Objection to longevity #5: cultural stagnation 33:28 The importance of human agency 41:01 How to influence the culture and policy 46:30 Objection to longevity #6: longevity is full of snake oil salesmen 49:20 US-China and the race to longevity 52:43 Evidence that aging is malleable 58:00 Eric and Daniel open up about their relationships 1:02:48 Is longevity a “luxury problem”? 1:06:21 The greatest crisis facing our generation

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Free Radicals retweetledi

Daniel Shur@teleodaniel·17 Şub

So excited to host @MartinBJensen on this week's episode the Free Radicals podcast! As the co-founder and CSO of @GordianBio, Martin has raised over $60M from top investors like @foundersfund , @HorizonsHK , @fiftyyears and The Longevity Fund, to revolutionize testing of therapeutics and targets at scale. Gordian also recently announced a partnership with @pfizer! Martin is also a prominent voice in longevity, and as the founder of @NornGroup he has also made countless contributions to the field more broadly, including through @impetusgrants. In this episode, Martin shares his insightful thoughts on the longevity field broadly, and also deep dives into Gordian's technology. This was a fun, wide ranging episode. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 03:27 Where is the longevity field today and are we on track to cure aging in our lifetimes? 14:25 Is longevity truly different from other areas of biotechnology? 16:07 What is aging? 22:13 An aging body is like a company that’s developed toxic bureacracy 26:46 Gordian’s approach to tackling aging 45:09 Will scale alone solve biology? 49:08 What data would superintelligent AI need to cure aging? 54:00 Unified theory of aging or biology 59:26 What understudied areas in aging deserve more attention? 1:02:23 How does loss of cellular identity relate to aging and disease? 1:10:07 Why are there no trillion-dollar biotechs and what would it take to create one? 1:17:32 What are the key components needed for a biotech flywheel? 1:21:43 How can biotech companies de-risk clinical development? 1:37:02 What is Norn Group and what problems does it address? 1:43:58 What opportunities exist for individuals to impact the aging field?

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Free Radicals retweetledi

Norn Group@NornGroup·17 Şub

How do we unlock faith in the longevity field? @MartinBJensen: "$250 billion for biomedical R&D per year in the US or $400 billion globally. Aging field globally is like $1 billion. So it's less than 1% of biomedical R&D. That's very low for something that is the primary risk factor for most of those diseases. Why is it low? Because nobody thinks it's going to work." But that’s starting to change.

Daniel Shur@teleodaniel

So excited to host @MartinBJensen on this week's episode the Free Radicals podcast! As the co-founder and CSO of @GordianBio, Martin has raised over $60M from top investors like @foundersfund , @HorizonsHK , @fiftyyears and The Longevity Fund, to revolutionize testing of therapeutics and targets at scale. Gordian also recently announced a partnership with @pfizer! Martin is also a prominent voice in longevity, and as the founder of @NornGroup he has also made countless contributions to the field more broadly, including through @impetusgrants. In this episode, Martin shares his insightful thoughts on the longevity field broadly, and also deep dives into Gordian's technology. This was a fun, wide ranging episode. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! And special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 03:27 Where is the longevity field today and are we on track to cure aging in our lifetimes? 14:25 Is longevity truly different from other areas of biotechnology? 16:07 What is aging? 22:13 An aging body is like a company that’s developed toxic bureacracy 26:46 Gordian’s approach to tackling aging 45:09 Will scale alone solve biology? 49:08 What data would superintelligent AI need to cure aging? 54:00 Unified theory of aging or biology 59:26 What understudied areas in aging deserve more attention? 1:02:23 How does loss of cellular identity relate to aging and disease? 1:10:07 Why are there no trillion-dollar biotechs and what would it take to create one? 1:17:32 What are the key components needed for a biotech flywheel? 1:21:43 How can biotech companies de-risk clinical development? 1:37:02 What is Norn Group and what problems does it address? 1:43:58 What opportunities exist for individuals to impact the aging field?

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Free Radicals retweetledi

Daniel Shur@teleodaniel·10 Şub

For our 10th episode of the Free Radicals podcast, @EricDai_BioE and I are excited to host @KarlPfleger After a decade as one of the first AI researchers at Google from 2002 to 2011, Karl dedicated himself to the cause of rejuvenation biotechnology. He is a philanthropist, community builder, and prolific angel investor with over 35 investments into rejuvenation biotech startups. His website, agingbiotech.info, provides valuable information to the entire field, and his talks and X posts are highly insightful and influential within longevity. Karl has deeply researched and nuanced takes, and those really show in this conversation. We cover why epigenetic reprogramming won’t solve aging, Karl’s investment strategy, what distinguishes true rejuvenation technology, why better diagnostic technologies could be the key to personalized aging interventions, and much more. Special thank you to @NFX & @omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 1:56 Peter Attia and defining longevity 8:37 What is aging? 12:41 Wear and tear vs programmed obsolescence 16:12 Which molecular mechanism of aging do we have the most control over? 19:29 Does partial reprogramming solve the whole aging problem? 25:23 How to identify truly rejuvenating therapies 32:35 The role of AI and good screening technologies 37:03 Do we understand the mechanisms of aging well enough to intervene? 38:39 Will there be a longevity tipping point? 44:51 Karl's investment strategy for aging biotech 52:21 Senolytics 1:01:33 Misfolded protein clearance & mitochondrial transplantation 1:08:21 Sauna & parabiosis (not combined) 1:15:54 Stem cell therapies 1:22:02 Karl's research process & formal techniques for evaluating arguments 1:28:55 The successes of the geroscience paradigm 1:34:13 Diagnostic bottlenecks

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Free Radicals retweetledi

Daniel Shur@teleodaniel·3 Şub

This week, we are excited to welcome @dives86 onto the Free Radicals podcast! Dr. Daniel Ives is the founder of @ShiftBioscience. Shift has built a novel single-cell aging clock that has enabled them to run high-throughput screens to discover genes that regulate aging, with the goal of identifying a therapy to systemically reverse aging. They’ve raised $16M from investors like Business Growth Fund, @FPrimeCapital, and @Kindred_VC to pursue this mission. In this episode, we discuss Shift’s formation and their approach, and dive deep into two promising targets they’ve discovered, as well as the coming cultural shift when anti-aging drugs become mundane reality. Be sure to follow @FreeRadicalsBio and @EricDai_BioE for weekly episodes about longevity biotech! 0:00 Intro 1:37 Deciding to work on aging 5:52 Origins of Shift Bioscience 9:54 Role of mitochondria in aging 13:03 Aging clocks & the meeting that led to XPRIZE Healthspan 18:11 Cracking the single cell aging clock 21:45 The accuracy and role of aging clocks 27:28 A single gene that reverses cellular age 36:59 Engineering small molecules for age reversal 43:07 How virtual cells accelerate scientific progress 49:55 From virtual cell to virtual human? 56:54 Asking the right questions 01:07:57 Backup plans 01:10:43 Lightning round

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Daniel Shur@teleodaniel·21 Oca

On this week's episode of the Free Radicals podcast, we are excited to host @NFX GP Dr. @omri_drory. Omri leads NFX Bio, and has backed iconic companies like @mammothbiosci, C2i Genomics and @centivax. His mission in life is to end involuntary death, and he has deployed large amounts of capital and effort towards that mission. I hope you enjoy this episode! And be sure to follow @FreeRadicalsBio & co-host @EricDai_BioE for weekly episodes! 0:00 Intro 1:47 Longevity can save America 6:05 Sci-fi and cultural negativity around longevity 11:28 Brain computer interfaces and an optimistic future 15:14 The race to 160 and reasons to believe in the future 20:42 ABCD plan to end death 24:23 Noticing when the tech tree is unlocked 28:54 Bottlenecks to longevity 33:09 Genetic engineering 35:04 Sci-Fi futures & the singularity 38:28 Why AI won’t solve everything for us (or why there’s still biology work to do) 48:08 Technologies to accelerate biotech into the clinic 53:21 Why biology is akin to alien technology 59:38 Most exciting work being done in biology 1:04:21 Advice on how to contribute to longevity 1:08:40 Sources of differentiation 1:16:11 Lightning round

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Free Radicals retweetledi

Eric Dai@EricDai_BioE·20 Oca

@teleodaniel and I are excited to host @NFX GP Dr. @omri_drory for this week’s episode of @FreeRadicalsBio! Omri is a scientist, operator, and investor who has founded, scaled, and backed some of today's most important techbio and longevity companies. Before becoming an investor, Omri was the founding CEO of Genome Compiler, which develops software for genetic engineers and molecular and synthetic biologists. He led the company to a successful acquisition by @TwistBioscience , a next-generation DNA synthesis company currently valued at $2.5 billion. As a founding partner at TechBio and GP at NFX, Omri has backed iconic companies like @mammothbiosci, C2i Genomics and @centivax. This conversation was supremely energizing and is a must listen episode for anyone interested in AI and longevity.

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Eric Dai@EricDai_BioE·14 Oca

@FreeRadicalsBio is back for 2026! @teleodaniel and I are thrilled to host @jacobkimmel on our first episode of the year. Dr. Jacob Kimmel is the Co-Founder and President of @newlimit. He co-founded NewLimit with @byersblake and @brian_armstrong, and has since raised over $300M from top venture capital funds like @_DimensionCap, @kleinerperkins, @foundersfund, and @khoslaventures. We chat with Jacob about why we age, what predictive biology is, how high quality data will unlock exponential takeoff in biological engineering, and why he avoids using the term longevity escape velocity. Dr. Kimmel has garnered a reputation as one of the brightest minds in longevity and the intersection between artificial intelligence and molecular biology. This is a must listen episode. Listen to the full episode here or in the replies. And subscribe for weekly episodes! 0:00 Intro 2:40 What is aging and why do we age 8:04 Epigenome as most validated layer for molecular regulation of aging 10:08 Germline rejuvenation (how nature makes young organisms from old ones) 14:40 Creating synthetic transcription factors 17:24 Where the information for youthful function is stored 18:55 DNA damage as an overrated driver of aging 23:46 NewLimit’s therapeutic programs & the Predictive Biology revolution 33:30 Scaling laws in biology and the early signs of a race towards biology’s own ChatGPT moment 41:12 Bottlenecks to inflecting EROOM’s law 46:45 Drug delivery 51:03 Aging’s common mechanisms 58:22 Advice on studying biology 1:01:44 The topics Jacob finds most confusing 1:03:17 An idea in biology that most get wrong 1:05:31 What tools are we lacking in biology today? 1:08:36 Organ replacement 1:11:23 How to think about lifespan extension 1:14:12 Who is doing the most important work in radical life extension 1:16:00 Lightning round

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Daniel Shur@teleodaniel·7 Oca

Happy new year from @FreeRadicalsBio! @EricDai_BioE and I will be back with episodes weekly again starting next week! We have many amazing guests lined up discussing the most exciting breakthroughs in longevity biotech.

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Daniel Shur@teleodaniel·16 Ara

In this week's episode of the Free Radicals podcast, @EricDai_BioE and I speak with @adamgries, a serial tech entrepreneur who is fomenting a revolution to cure aging and death. Have you fallen for the myth that the billionaires are already pumping all the resources we need into longevity research? That we are implementing "maximum effort" against the #1 cause of death? Adam argues that we're not even close - our society needs a major revolution if we are going to have a shot at not dying. 0:00 Intro 7:12 Why aging is solvable 11:00 Theories of aging 15:35 Are billionaires all wasting their money on longevity? 26:02 Why the incentives are broken for both the public and private sectors to tackle aging 31:08 Some thought on how to fix the system 34:11 How Vitalism intends to create influence networks to create a revolution 44:50 The longevity “death apologists” 47:33 Should the longevity movement be more conservative? 49:03 The confabulation of “death gives life meaning” 58:53 What will determine the future? 1:07:11 AI’s role in curing aging 1:13:16 Vipassana and the fundamental nature of reality 1:24:09 Advice to those that want to work on aging

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Free Radicals@FreeRadicalsBio·9 Ara

Follow us on YouTube, your podcast platform of choice and Substack! Youtube: youtu.be/KoTPoPl2hcU Spotify: open.spotify.com/episode/6M67ZU… Apple Podcasts: podcasts.apple.com/us/podcast/rep… Substack for Transcript: freeradicalspodcast.substack.com/p/reprogrammin…

YouTube

Daniel Shur@teleodaniel

In today's episode of the Free Radicals podcast, @EricDai_BioE and I hosted Dr. @JanineSengstack & @robcahill10 , co-founders of @junevity . They are on a mission to extend lifespan and healthspan by combining AI and large scale omics data with genetic medicines known as “siRNAs”. Their cellular reset platform promises to create medicines that can reset each of your organs back to a healthy and youthful state. This year, Junevity successfully restored "18-year-old metabolism" in animal models allowing mice on a high-fat diet to lose fat while retaining muscle. This candidate therapy may become the first known drug to rejuvenate metabolism. They just announced that they doubled their seed round funding up to $20M to advance this work into human clinical trials, which means we might see their first rejuvenating medicine in the clinic as soon as the second half of next year. 0:00 Intro 2:29 Junevity’s Cell Reset Platform 3:57 The science behind the platform 8:34 Rob’s transition from exited tech founder to biology student 12:59 What makes for good co-founder relationships 16:12 Why right now is the moment for longevity biotech 18:05 Black box AI vs traditional biology 23:21 Advantages of siRNAs for cell reset 32:32 Junevity’s secret sauce 36:09 The primary challenge in all preclinical work today 40:16 siRNAs for obesity 49:04 Timing for achieving longevity escape velocity 55:26 The Ozempic or ChatGPT moment for longevity 1:02:54 Bottlenecks to accelerating longevity 1:07:31 What’s next for Junevity

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Daniel Shur@teleodaniel·2 Ara

Episode 3 of the Free Radicals podcast is here! This week @EricDai_BioE and I are joined by @ladanuzhna , Founder and CEO of General Control, a biotech startup developing targeted epigenetic editing tools to treat diseases of aging backed by @age1vc and @fiftyyears . In this conversation, we discuss Lada’s inspiration to start General Control, why biotech has failed to address aging, what needs to change, and much more. 0:00:00 Intro 00:02:12 First principles biology 00:06:43 We don’t collect enough of the right data for aging 00:09:41 Impetus grants funds novel rather than incremental science 00:12:52 Academic funding environment is dramatically changing 00:16:08 Incentives are misaligned to fund longevity therapies in the US 00:19:49 Are GLP-1s a longevity drug? 00:21:49 Lada’s startup: scalpel-like epigenetic editing 00:35:08 Everyone is using aging clocks but we don’t know what they’re doing 00:42:10 We don’t have good animal models for aging 00:45:54 The two types of longevity companies 00:48:30 Where are all the trillion-dollar biotechs 00:52:07 Will AI help us develop the next blockbusters? 00:54:52 Platform biotechs 00:59:04 Lightning round I hope you enjoy this episode! Join us for discussions every Tuesday with the scientists and builders working to dramatically extend human lifespan and bring about a sci-fi future!

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Free Radicals@FreeRadicalsBio·25 Kas

Check out the the full episode on YouTube & podcast platforms! We tried to upload to X but the internet gods just weren't favoring us today... will try again soon :) YT: youtu.be/5zwp-WRIJ28?si… Spotify: open.spotify.com/episode/0eUasJ… Apple Podcasts: podcasts.apple.com/us/podcast/how…

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Daniel Shur@teleodaniel

Episode 2 of Free Radicals just dropped! This week we are joined by Dr. @AlexJColville, a Stanford-trained aging biologist who has invested over $175M into longevity. We discuss whether aging is wear and tear or planned obsolescence, his strategy for investing into longevity biotech, cryopreservation, and much more! Trailer below! Go to my bio or @FreeRadicalsBio for links to to the full podcast on YouTube, Spotify, and Apple Podcasts.

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Daniel Shur@teleodaniel·18 Kas

Today I am launching the Free Radicals podcast with @EricDai_BioE . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host @celinehalioua, Founder + CEO @loyalfordogs, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, @EricDai_BioE and @FreeRadicalsBio for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS

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