Juan Bravo, PhD

Noted on Bluesky a while back but updating here as well: Happy to share the published version of our last study, where we employed a multi-ancestry GWAS to identify human variants associated with elevated transposon (LINE-1 and Alu) insertion numbers. pubmed.ncbi.nlm.nih.gov/40051556/

Years in the making: a detailed aging gene signature in mice and rats. >30 tissues, high Ns, multi-time points throughout the lifespan. >5000 samples in total. The data is accessible, so you check to see if your favorite gene is age-regulated. science.org/doi/10.1126/sc…

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications cell.com/ajhg/fulltext/… 🧬🖥️🧪

Ambient RNA & barcode swapping is a serious issue in single-cell genomics. Tools such as CellBender, scAR, DecontX & SoupX. We have developed CellSweep which is faster (in some cases by a lot) and much more accurate. Extensively tested and benchmarked. biorxiv.org/content/10.648… 1/

Jumping 'DNA parasites' linked to early stages of tumor formation medicalxpress.com/news/2026-02-d…

Henry L. Levin, Ph.D. has updated his Editor’s Picks for January with standout papers covering topics such as LINE-1 retrotransposons and other advances in genome biology. Take a look 👇 link.springer.com/journal/13100/… 📸 Figure adapted from Grinwald MF et al., Trends in Genetics, 2025.

TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data link.springer.com/article/10.118…

🧬 New Research Highlight 🧠 A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways by Juan I. Bravo & Bérénice A. Benayoun (@BBParis1984) et al. This multi‑omics study shows how Alu transposon overexpression in human fibroblasts disrupts key aging‑related pathways, offering deeper insight into genomic instability and cellular aging mechanisms. 🔗 Read the full paper: rdcu.be/eYAhr

Another group following up on the work from my PhD, linking LINE-1 transposon expression to aging phenotypes!

Parental age selection in C. elegans influences progeny stress resistance capacity academic.oup.com/biomedgerontol…

🔬 Developed a multi-omics approach to analyze Alu transposon impacts on fibroblast aging pathways. 🔗 doi.org/10.1007/s11357… #Proteomics #MassSpec

The efficacy of longevity interventions in Caenorhabditis elegans is determined by the early life activity of RNA splicing factors journals.plos.org/plosbiology/ar…

Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals biorxiv.org/content/10.110…

New pre-print: We show that L1 insertion intermediates can recombine with one another or with DNA breaks to form genome rearrangements, highlighting the risk of L1 retrotransposition generating substrates for aberrant recombination and genome instability. biorxiv.org/content/10.110…

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development dlvr.it/TMdp9S

A noncanonical cGAS–STING pathway drives cellular and organismal aging pnas.org/doi/10.1073/pn…

Single-cell eQTL mapping of human endogenous retroviruses reveals cell type-specific genetic regulation in autoimmune diseases nature.com/articles/s4146…

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways biorxiv.org/content/10.110…

A multi-omics analysis of human fibroblasts overexpressing an Alu transposon reveals widespread disruptions in aging-associated pathways biorxiv.org/content/10.110… #biorxiv_genomic

New life-extending molecules in mice were shared in a recent preprint Two of them (selumetinib and vorinostat) increased lifespan across genetically heterogenous mice Excited to see what Altos Labs does with them!

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