John Caleb

Demis Hassabis (@demishassabis) has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads @GoogleDeepMind, pushing toward the same goal he set as a teenager: AGI. On this special live episode of How to Build the Future, he sat down with YC's @garrytan to talk about what still needs to happen to get us to AGI, his advice for founders on how to stay ahead of the curve, and what the next big scientific breakthroughs might be. 01:48 — What’s Missing Before We Get To AGI? 03:36 — Why Memory Is Still Unsolved 06:14 — How AlphaGo Shaped Gemini 08:06 — Why Smaller Models Are Getting So Powerful 10:46 — The 1000x Engineer 12:40 — Continual Learning and the Future of Agents 13:32 — Why AI Still Fails at Basic Reasoning 15:33 — Are Agents Overhyped or Just Getting Started? 18:31 — Can AI Become Truly Creative? 20:26 — Open Models, Gemma, and Local AI 22:26 — Why Gemini Was Built Multimodal 24:08 — What Happens When Inference Gets Cheap? 25:24 — From AlphaFold to the Virtual Cells 28:24 — AI as the Ultimate Tool for Science 30:43 — Advice for Founders 33:30 — The AlphaFold Breakthrough Pattern 35:20 — Can AI Make Real Scientific Discoveries? 37:59 — What to Build Before AGI Arrives

@Abee_john 😅

@thejohncaleb No please 😂😂

Been a huge fan of Michael Jackson since forever. 🥹❤️ Stepped out to watch his biopic 🥹😭

@MaryRoseMalomo omg 😭

In Loving Memory 🕊️ She carried quiet dreams and showed up even when no one was watching. She believed in growth, in time, in becoming. Today, we gather not in sorrow but in acknowledgment of how far she’s come. 10.8k witnesses to a life that refused to stay small. Thank you for being part of the journey. The story continues. 🕊️✨”

@layiwasabi 😂😂

pov: effort vs result

Playing around with my ESP32 and @CloudflareDev Voice Agents, and Mesh to control my Elgato lights. My colleague @lauragift_ is working on a better demo/tutorial on this. Stay tuned and follow her!

We’re bringing Jensen Huang to Startup School for a fireside chat with @garrytan! From co-founding @nvidia in 1993 to building the backbone of the AI era, Jensen helped turn GPUs into the engine of modern computing. Apply to attend: events.ycombinator.com/startup-school…

We are excited to announce that THE AWS Cloud Club FUTMinna is officially transitioning into 𝑨𝑾𝑺 𝑺𝒕𝒖𝒅𝒆𝒏𝒕 𝑩𝒖𝒊𝒍𝒅𝒆𝒓𝒔 𝑮𝒓𝒐𝒖𝒑 𝑭𝑼𝑻𝑴𝒊𝒏𝒏𝒂. Worry not, it's still the same community but bigger vision, better opportunities.💐 ..so come check out the AWSome co

This summer we're launching YC Paper Club to bring researchers & builders together. Every few weeks we'll host a small group dinner in Mountain View to share and discuss new research papers. Interested in both research & building the future? Sign up at: events.ycombinator.com/ycpaperclub

Cool stuff

the best thing I've seen on the internet today!

We saw how stressful job interviews can be, and decided to change it. MockPrepAI gives you clarity, structure, and real-time feedback. Because your success shouldn’t be trial and error. mockprepai.com #MockPrepAI #JobInterviewPrep #InterviewPreparation #CareerGrowth #CareerDevelopment #JobSearchTips #InterviewTips #TechForGood #AItools #FutureOfWork #GetHired #CareerSuccess #ProfessionalDevelopment

Warp is now open-source.

4 years ago, a team of 7. Today, a team of 70. What does it feel like to build a SaaS company in the middle of a global transition? Kelvin talks through it. Watch the full conversation here: youtu.be/UXm-A_sF5nw This episode is sponsored by @sendwaveapp

gonna save mine as 0000001-[firstname]-[lastname].pdf in case everyone else tries this 😅

Here's YC's official advice about being truthful and precise about what is pilot, bookings, revenue and recurring revenue. Founders, particularly first time founders, need to sear this into their brains. Don't mistake one tier for another. Be precise, and always be truthful.

😅