Trotman Lab

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To Black Academics, • (1/2)

CSHL Cancer Center Director David Tuveson was chosen President-Elect of @AACR: “AACR’s mission is to improve the lives of people world-wide... Collectively we can solve the hardest problems and help the most cancer patients.” cshl.edu/david-tuveson-…

We are recruiting post-docs and technicians in our lab at the newly-established Precision Medicine Division at Kyushu University (no website yet!). We are looking for enthusiastic, self-motivated individuals who can interact well with others as part of a team! Plz RT.

I agree, and the solution is key to our survival: more money for research and education. Fortunately, it’s an election year and we’ll all be fighting the good fight, right?

History is a great teacher; we should pay more attention so we don’t repeat the mistakes made during the 1918 flu pandemic; some very poignant graphs in this @NatGeo story #COVID2019 #CoronavirusPandemic on.natgeo.com/2UIEnGH

Awesome NYT ‚Exposé’ with mugshots of the Coronavirus proteins that are harmless to bats and lethal to us. nytimes.com/interactive/20…

I swear to god if the cure for COVID-19 ends up having something to do with the Krebs cycle I'm gonna fucking lose it

Intriguing new role for LKB1 in preventing squamous PC, the most lethal type of prostate cancer. Happy to have written a JEM Insight on the emerging concept with Grinu. rupress.org/jem/article/21… rupress.org/jem/article-ab…

@MarkJHandley You did amazing work to help prevent even more damage! Your early analysis was key to closing local schools in our NY area at a time when everyone was focused on testing and Italy.

For those following my #COVID19 updates, I'm going to issue them every two days from now on. After 21 consecutive days of not managing to do much else, I think the "early warning" aspect of these updates has mostly now been achieved, and I really need more sleep. Stay safe!

Disease carriers vs those with symptoms impressively captured in Iceland vs. Netherlands.

Excellent discussion of the gender distribtution of #COVID19 and potential link to androgens/ TMPRSS2.

@HaigisLab Brain Child and Brain Games. Take care! L

50 lines that tell our story. Research is the antidote.

Does anybody know about emerging clinical data on Covid impact on men that are on anti-androgens versus not?

Amazing data on gender differences. TMPRSS2 is essential for CoV-2 entry. Its levels may be higher in lungs of men. cell.com/cell/fulltext/…

Not subtle: “FOXA1 was the most highly mutated gene in our Chinese cohort (41%). By contrast, FOXA1 was mutated in only 4% of TCGA prostate cancer and in 8–9% of primary prostate cancer and 12–13% of metastatic prostate cancer” ⁦@nature nature.com/articles/s4158…

@ScienceMagazine @GaviSeth @gavi I am a bit shocked by this tweet by Science… An ideal scientific collaboration should be “without” terrible implications for humanity...

Literally sickening. Which other democracy puts up with this kind of opposite of a leader?

@NimaSharifiMD What do you think about including DHT in lung cell culture experiments with COVID-2?

@trotmanlab Haven’t seen anything on androgens in mouse lung. Would expect gonadal T exposure, not very much adrenal androgens.

Would definitely be worth testing. Unfortunately, if I remember discussion with @NimaSharifiMD correctly, mouse does not show the androgen levels seen in human lung, so would be a bad model- but I may be wrong here...