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Taha Y. Taha
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Taha Y. Taha
@ttaha801
Husband, father, virologist, pharmacist, soccer player, and chess enthusiast 🦠🧬😷 🥼 🔬⚽♞ Working on HBV and SARS-CoV-2 @TheOttLab @GladstoneInst
San Francisco, CA Katılım Eylül 2020
2.4K Takip Edilen359 Takipçiler
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Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing.
biorxiv.org/cgi/content/sh…
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Just posted a preprint on a huge new single-cell study of Parkinson’s and its application to understanding noncoding variation. 🧵below. Led by Shreya Menon and Adam Turner and in collab w/ GP2 (@ASAP_Research), @BelloyMichael, @ZihHuaFang and others. doi.org/10.64898/2026.…
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The first time you start a research lab, there’s no manual.
So I made one.
A practical toolkit for postdocs and early-career faculty launching their first lab: hiring, startup planning, collaborations, and building a sustainable research program.
zenodo.org/records/188835…
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1) We have a new preprint paper out about population immunity to H5N1 and H5N5. Results are in line with what others have seen but there are two new findings. medrxiv.org/content/10.648…
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Thrilled to share the first major preprint from the lab. Viruses are classically viewed as targets of host sensing. Do viruses also sense and respond to the host? We propose viruses may act as “biosensors” of the host signaling state. A thread👇🏾
biorxiv.org/content/10.110…
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SARS-CoV-2 continue to surprise us with evolutionary jumps. In this pre-print, we describe the Identification and genomic characterisation of BA.3.2: a highly divergent BA.3-related SARS-CoV-2 lineage from southern Africa. A thread 🧵 medrxiv.org/content/10.648…
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Excited to share our new work on immune aging! We explored whether the liver could serve as a temporary "factory" to produce immune factors that decline with aging, potentially helping to rejuvenate aged immunity. @mircoscopy.
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@LongDesertTrain Do all the sequences available have the accessory protein deletion?
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With 30 new BA.3.2 sequences from the Netherlands and Denmark uploaded today, this is beginning to have a look of inevitability about it.
Still waiting for a recombinant that restores ORF7a, ORF7b, and ORF8 (all entirely deleted in BA.3.2).
Marc Johnson@SolidEvidence
Three more BA.3.2 detections from US wastewater. Rhode Island (different sewershed, but near the previous one), Vermont, and Florida. All from CDC NWSS data. Looks like it might be getting a foothold in New England. @LongDesertTrain @siamosolocani @snpoehlm
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Today in @Nature, in work led by @aditimerch, we report the ability to prompt Evo to generate functional de novo genes.
You shall know a gene by the company it keeps! 1/n
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Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases.
(1/15)
drive.google.com/file/d/1bSvkJW…
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So awesome to have this great paper from @SamReffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
cell.com/cell/fulltext/…
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Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals
go.nature.com/4qX6KiM
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Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵
nature.com/articles/s4158…
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Danya was a Chess Life magazine columnist from 2014 through 2020, writing a monthly column on endgames.
Now, all of his columns can be downloaded as one .pdf file here (no US Chess membership required):
uscf1-nyc1.aodhosting.com/CL-AND-CR-ALL/…
US Chess@USChess
US Chess is saddened to learn that GM Daniel Naroditsky has died. Naroditsky was a World Youth and U.S. Junior champion, and also a beloved educator, streamer, Chess Life columnist, and part of the @CLTchesscenter community. 📷 Lennart Ootes/@STLChessClub new.uschess.org/news/gm-daniel…
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I've been sitting here numb for the past hour staring at this news. The world lost a brilliant man today. May his memory live on forever and may we always cherish his contributions to our beautiful game.
Charlotte Chess Center@CLTchesscenter
The Naroditsky family shares the sad news of Daniel’s unexpected passing. Daniel was a talented chess player, educator, and beloved member of the chess community. We ask for privacy as the family grieves.
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🦖 Something HUGE just hatched.
Plasmidsaurus now offers RNA sequencing for gene expression analysis with:
• As fast as 3 day turnaround
• $50/sample for academia, $80 for industry
• Up to ~10M unique transcript 3’ end reads per sample
• Interactive results that let you explore changes in genes and pathways
Explore Plasmidsaurus RNA-Seq today.
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