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Tim Worden
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Tim Worden
@twflawless
Freedom is a system, not a feeling. Building health, leverage, and AI.
Florida Katılım Nisan 2009
316 Takip Edilen785 Takipçiler

@thejustinwelsh Net worth means nothing without net time. One buys freedom, the other rents status.
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@SahilBloom The thing you keep avoiding is the map. Resistance always points toward the thing that matters.
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@CoachDanGo Everyone wants the advanced protocol. Nobody wants the boring one that works.
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@CoachDanGo Three ingredients, zero branding. The best protocols never need a label.
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@Nithya_Shrii The applause fades in minutes. The statement never leaves the account.
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@CoachDanGo Hunger is just a signal, not a command. The gap between the two is where the cut happens.
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@bryan_johnson In vitro panic sells clicks. In vivo context sells nothing. That’s why the headlines never include it.
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The totality of evidence does not support the conclusion that dietary erythritol drives cardiovascular harm.
The paper referenced claims erythritol “adversely affects brain microvascular endothelial cell function,” but it’s an in VITRO study bathing isolated cells in erythritol for 3 hours. People are using epidemiology data to frame the results of that mechanistic, in vitro study as confirming cardiovascular risk from erythritol consumption. The referenced study is interesting and possibly defensible from a mechanistic perspective, but using it to make conclusive claims about the dangers of erythritol consumption is a different story.
Erythritol-harm supporters largely ignore that humans produce erythritol endogenously.
It’s a byproduct of the pentose phosphate pathway, and that pathway is upregulated in states of hyperglycemia, oxidative stress, and pre-existing cardiovascular disease.
The landmark paper from Nature Medicine (2023), often referenced by many who are concerned about erythritol’s safety, never controlled for this. The ARIC metabolomics study from the late 80s (before erythritol entered the food supply) already showed the erythritol-CVD association. If the signal predates dietary exposure, elevated circulating erythritol is almost certainly a biomarker of metabolic dysfunction, not necessarily the cause of it.
People with diabetes and insulin resistance endogenously overproduce erythritol and might preferentially consume erythritol-sweetened products. That’s a major confounding factor, making it essentially impossible to untangle in observational data.
The strongest causal evidence we have, Mendelian randomization, doesn’t support the conclusions many are making about the safety of erythritol consumption. Most MR analyses find no causal link between genetically-predicted erythritol levels and coronary artery disease, diabetes, or chronic kidney disease.
A 2025 MR did find associations with CVD and stroke, but the effect sizes were negligible. It’s also worth emphasizing that MR analyses can’t distinguish endogenous from exogenous erythritol. Actual human clinical trials show erythritol improved endothelial function and reduced aortic stiffness in T2D patients over 4 weeks.
Patrick Sullivan Jr.@realPatrickJr
This is extremely concerning! A new study found that the sweetener used in millions of Americans' daily snacks can damage human brain cells within hours of a single serving. The FDA approved it decades ago, but the new data is worrying: (1/15)
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@thedankoe Obsession looks like boredom from the outside. Same inputs, same reps, years longer than anyone watches.
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@SahilBloom Reliability is rare because it’s boring. That’s exactly why it compounds.
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